A5040438371- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Neutrino Physics Research
- Dark Matter and Cosmic Phenomena
- Advanced biosensing and bioanalysis techniques
- Astrophysics and Cosmic Phenomena
- DNA and Nucleic Acid Chemistry
- Fuel Cells and Related Materials
- Epigenetics and DNA Methylation
- Cosmology and Gravitation Theories
- Cancer-related gene regulation
- Conducting polymers and applications
- RNA Interference and Gene Delivery
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Parkinson's Disease Mechanisms and Treatments
- Biopolymer Synthesis and Applications
- biodegradable polymer synthesis and properties
- Advanced battery technologies research
- Cancer Cells and Metastasis
- Allergic Rhinitis and Sensitization
Okayama University of Science
2016-2025
Kawasaki Medical School
2025
Hokkaido University
1996-2024
Komaki City Hospital
2023
Taiho Pharmaceutical (Japan)
2011-2022
Ochanomizu University
2022
Meijo University
2022
GlaxoSmithKline (Japan)
2012-2021
Osaka Medical and Pharmaceutical University
2020
Tohoku University
2015-2019
A neutrino burst was observed in the Kamiokande II detector on 23 February, 7:35:35 UT (\ifmmode\pm\else\textpm\fi{}1 min) during a time interval of 13 sec. The signal consisted 11 electron events energy 7.5 to 36 MeV, which first two point back Large Magellanic Cloud with angles 18\ifmmode^\circ\else\textdegree\fi{}\ifmmode\pm\else\textpm\fi{}18\ifmmode^\circ\else\textdegree\fi{} and 15\ifmmode^\circ\else\textdegree\fi{}\ifmmode\pm\else\textpm\fi{}27\ifmmode^\circ\else\textdegree\fi{}.
Neutrinos from the decay of $^{8}\mathrm{B}$ in Sun have been observed Kamiokande-II detector. Based on 450 days data time period January 1987 through May 1988; measured flux obtained with ${E}_{e}$\ensuremath{\ge}9.3 MeV is 0.46\ifmmode\pm\else\textpm\fi{}0.13(stat)\ifmmode\pm\else\textpm\fi{}0.08(sys) value predicted by standard solar model. Within experimental errors, agreement corresponding $^{37}\mathrm{Cl}$ radiochemical detector essentially same period.
A data sample of 1040 days from the Kamiokande II detector, consisting subsamples 450 at electron-energy threshold Ee≥9.3 MeV and 590 Ee≥7.5 MeV, yields a clear directional correlation solar-neutrino-induced electron events with respect to Sun measurement differential distribution. These provide unequivocal evidence for production B8 by fusion in Sun. The measured flux solar neutrinos two relative prediction standard model is 0.46±0.05(stat)±0.06(syst). total tested short-term time...
The properties of the Kamiokande-II detector and method measurement are described in detail. data on neutrino burst from supernova SN1987A 23 February 1987 at 7:35:35 UT\ifmmode\pm\else\textpm\fi{}1 min presented, with records earlier later observation periods which other events possibly associated might have occurred. There is no evidence for any excess neutrino-induced events, either a few seconds duration or over longer time interval, relative to usual count rate, excepting only UT....
To clarify the relationships between performance of dye-sensitized solar cells and their internal resistances, we applied ac impedance spectroscopy to analysis cells. Impedance measurements were carried out for various cell compositions measurement conditions such as different kinds conductive glass substrates, two counter electrodes, calcination temperature, bias, distance electrodes; in order separate resistances which occur at interfaces. spectra showed that resistance consisted least...
Abstract To elucidate the role of α‐synuclein in pathogenesis Parkinson's disease, both human transgenic mice and targeted overexpression rat substantia nigra using viral vector‐based methods have been studied, however, little is known about pathogenetic changes dopaminergic neuron loss. Therefore, it necessary to address whether brains with disease are recapitulated these models. Here, we used recombinant adeno‐associated (rAAV) vector system for gene transfer observed approximately 50%...
The method of $^{8}\mathrm{B}$ solar-neutrino measurement by means the reaction ${\ensuremath{\nu}}_{e}e\ensuremath{\rightarrow}{\ensuremath{\nu}}_{e}e$ in Kamiokande II detector is described detail. A data sample 1040 live days time period January 1987 through April 1990 yields a clear directional correlation solar-neutrino-induced electron events with respect to Sun and differential energy distribution. measured flux solar neutrinos from subsamples 450 at threshold...
Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model Parkinson's disease. The wild-type caspase recruitment domain Apaf-1 used as dominant (rAAV-Apaf-1-DN-EGFP). An AAV to deliver it into the striatum C57 black mice, and animals were treated with MPTP. number tyrosine hydroxylase-positive substantia nigra not changed...
An analysis of the Mikheyev-Smirnov-Wolfenstein effect using 1040 days Kamiokande-II data is reported, which provides constraints on neutrino-oscillation parameters. The measured recoil-electron energy spectrum alone leads to conclusion that adiabatic region, 7.2\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}4}$${\mathrm{sin}}^{2}$2\ensuremath{\theta}6.3\ifmmode\times\else\texttimes\fi{}${10}^{\mathrm{\ensuremath{-}}3}$,...
The present study was designed to elucidate the inflammatory and apoptotic mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in a model Parkinson's disease. Our results showed that mutant mice lacking caspase-11 gene were significantly more resistant effects acute treatment with MPTP than their wild-type mice. Thus, seems be mediated by induction both mitochondrial dysfunction free radical generation. Previously, we overexpression Apaf-1...
A fabric with different functions on its two sides has unparalleled advantages for practical use.
Abstract The activities to induce TNF-α production by a monocytic cell line, THP-1, and ICAM-1 expression IL-6 human gingival fibroblasts were detected in plural membrane lipoproteins of Mycoplasma salivarium. Although SDS-PAGE the digested proteinase K did not reveal any protein bands with molecular masses higher than approximately10 kDa, these front gel. A lipoprotein mass 44 kDa (Lp44) was purified. Proteinase affect expression-inducing activity Lp44, but lipase abrogated activity. These...
Bone marrow stromal cells (BMSCs) have many characteristics of mesenchymal stem that can differentiate into smooth muscle (SMCs). However, there been few studies closely following the cell development lineage among BMSCs.To investigate possible existence a population committed to SMC bone adhesion cells, we tried detect and follow in vitro differentiation such type by using promoter-sorting method with human SM22alpha promoter (-480 bp)/green fluorescent protein (GFP) construct. The...
Recently, anhydrous proton-conducting membranes have attracted remarkable interest for application to the polymer electrolyte membrane fuel cell (PEMFC) operated at intermediate temperature (100−200 °C). In this paper, we prepared self-assembled acid−base composite material with highly ordered molecular array through hybridization of acidic surfactant monododecyl phosphate (MDP) and basic 2-undecylimidzole (UI) molecules. This UI−MDP has been found form lamellar structures a d spacing...
Laminin, a major component of the basement membrane, has diverse biological activities. Recently, we identified various biologically active sequences on laminin-1 by using large set synthetic peptides. Chitosan, polysaccharide, is biodegradable and been used as biomaterial. Here, conjugated several laminin peptides onto chitosan membranes measured cell attachment activity peptide-conjugated with types. The promoted type specificity. A99 (AGTFALRGDNPQG)-chitosan membrane well-organized actin...