A5070747855- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Insect Utilization and Effects
- Neurobiology and Insect Physiology Research
- Sirtuins and Resveratrol in Medicine
- Biochemical Analysis and Sensing Techniques
- Genetics, Aging, and Longevity in Model Organisms
- Biochemical effects in animals
- Circular RNAs in diseases
- Glutathione Transferases and Polymorphisms
- Free Radicals and Antioxidants
- MicroRNA in disease regulation
- Natural Antidiabetic Agents Studies
- Vitamin C and Antioxidants Research
- Heme Oxygenase-1 and Carbon Monoxide
- Circadian rhythm and melatonin
- Phytoestrogen effects and research
- Curcumin's Biomedical Applications
- Ion channel regulation and function
- Paraoxonase enzyme and polymorphisms
- Probiotics and Fermented Foods
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
Justus-Liebig-Universität Gießen
2019-2024
University of Lübeck
2005-2020
University Hospital Schleswig-Holstein
2017-2020
Kiel University
2008-2017
Clinical Research Center Kiel
2015-2016
University of California, Davis
2015
TU Dresden
2013
Karlsruhe Institute of Technology
2011-2012
Niigata University of Pharmacy and Medical and Life Sciences
2008
Kanazawa University
2008
Regular consumption of flavonoids may reduce the risk for CVD. However, effects individual flavonoids, example, quercetin, remain unclear. The present study was undertaken to examine quercetin supplementation on blood pressure, lipid metabolism, markers oxidative stress, inflammation, and body composition in an at-risk population ninety-three overweight or obese subjects aged 25–65 years with metabolic syndrome traits. Subjects were randomised receive 150 mg quercetin/d a double-blinded,...
Abstract Background Both resveratrol and vitamin C (ascorbic acid) are frequently used in complementary alternative medicine. However, little is known about the underlying mechanisms for potential health benefits of its interactions with ascorbic acid. Methods The antioxidant enzymes heme oxygenase-1 paraoxonase-1 were analysed their mRNA protein levels HUH7 liver cells treated 10 25 μmol/l absence presence 100 1000 Additionally transactivation transcription factor Nrf2 determined by...
In this study, the underlying mechanisms of potential anti-inflammatory properties allyl-isothiocyanate (AITC) were analysed in vitro and vivo. Murine RAW264.7 macrophages stimulated with lipopolysaccharide (LPS) supplemented increasing concentrations AITC. addition, C57BL/6 mice (n= 10 per group) fed a pro-inflammatory high-fat diet AITC was administered orally via gavage for 7 days. Biomarkers inflammation determined both cultured cells mice. significantly decreased tumour necrosis factor...
A Mediterranean diet rich in olive oil has been associated with health benefits humans. It is unclear if and to what extent phenolics may mediate these benefits. In this study, we fed senescence-accelerated mouse-prone 8 (SAMP8, n=11 per group) semisynthetic diets 10% containing either high (HP) or low amounts of (LP) for 4.5 months. Mice consuming the HP had significantly lower concentrations oxidative damage markers thiobarbituric acid–reactive substances protein carbonyls heart, whereas...
Drosophila melanogaster has been widely used in the biological sciences as a model organism. relatively short life span of 60-80 days, which makes it attractive for studies. Moreover, approximately 60% fruit fly genes are orthologs to mammals. Thus, metabolic and signal transduction pathways highly conserved. Maintenance reproduction do not require sophisticated equipment rather cheap. Furthermore, there fewer ethical issues involved experimental research compared with studies laboratory...
Nrf2 is a basic leucine zipper transcriptional activator essential for the coordinated induction of phase-2 and antioxidant enzymes. Brassica vegetables contain phytochemicals including glucoraphanin, precursor sulforaphane (SFN) glucobrassicin, indole-3-carbinole (I3C) ascorbigen (ABG). The degradation products SFN, I3C ABG may be capable inducing cytoprotective genes in skin. In this study, we tested potency affecting Nrf2-dependent gene expression human keratinocytes culture. SFN but not...
// Anika E. Wagner 1 , Stefanie Piegholdt Doerte Rabe Nieves Baenas 1, 2 Anke Schloesser Manfred Eggersdorfer 3 Achim Stocker 4 Gerald Rimbach Institute of Human Nutrition and Food Science, University Kiel, Germany Centro de Edafología y Biología Aplicada del Segura (CEBAS-CSIC), Campus Universitario Espinardo, Murcia, Spain DSM Nutritional Products, Basel, Switzerland Department Chemistry Biochemistry, Bern, Correspondence to: Wagner, e-mail: wagner@molecularnutrition.uni-kiel.de Rimbach,...
Several studies have been published introducing Drosophila melanogaster as a research model to investigate the effects of high-calorie diets on metabolic dysfunctions. However, differences between use high-sugar (HSD) and high-fat (HFD) affect fly physiology, well influence sex age, seldom described. Thus, aim present work was compare HSD (30% sucrose) HFD (15% coconut oil) symptoms dysfunction related obesity type-2 diabetes mellitus, including weight gain, survival, climbing ability,...
In order to gain a more comprehensive understanding of the aetiology apolipoprotein E4 genotype-cardiovascular disease (CVD) associations, impact apoE genotype on macrophage inflammatory response was examined. The murine monocyte-macrophage cell line (RAW 264.7) stably transfected produce equal amounts human apoE3 or apoE4 used. Following LPS stimulation, apoE4-macrophages showed higher and lower concentrations tumour necrosis factor alpha (pro-inflammatory) interleukin 10...
Muscle atrophy is a process of muscle wasting induced under series catabolic stress conditions, such as denervation, disuse, cancer cachexia, heart and renal failure, AIDS, aging. Neuromuscular junctions (NMJs), the synapses between motor neurons fibers undergo major changes in atrophying muscles, ranging from mild morphological alterations to complete disintegration. In this study, we hypothesized that remodeling NMJs could be linked together. To test this, examined if atrophy-promoting E3...
The bivalve Arctica islandica is extremely long lived (>400 years) and can tolerate periods of hypoxia anoxia. European populations differ in maximum life spans (MLSP) from 40 years the Baltic to >400 around Iceland. Characteristic behavior A. involves phases metabolic rate depression (MRD) during which animals burry into sediment for several days. During these shell water oxygen concentrations reaches hypoxic anoxic levels, possibly support span some populations. We investigated gene...