A5049535196- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Muscle Physiology and Disorders
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- High Altitude and Hypoxia
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Alcohol Consumption and Health Effects
- Circadian rhythm and melatonin
- Cancer, Lipids, and Metabolism
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Mycotoxins in Agriculture and Food
- Selenium in Biological Systems
- Tissue Engineering and Regenerative Medicine
- Circular RNAs in diseases
- Muscle metabolism and nutrition
Jagiellonian University
2015-2024
Lomonosov Moscow State University
2016
University of Florida
2004
University of Gdańsk
2004
Heme oxygenase-1 (HO-1, HMOX1) can prevent tumor initiation; while in various tumors, it has been demonstrated to promote growth, angiogenesis, and metastasis. Here, we investigated whether HMOX1 modulate microRNAs (miRNAs) regulate human non-small cell lung carcinoma (NSCLC) development.Stable overexpression NSCLC NCI-H292 cells up-regulated tumor-suppressive miRNAs, whereas significantly diminished the expression of oncomirs angiomirs. The most potently down-regulated was miR-378. also...
Nuclear factor E2-related 2 (Nrf2), a key cytoprotective transcription factor, regulates also proangiogenic mediators, interleukin-8 and heme oxygenase-1 (HO-1). However, hitherto its role in blood vessel formation was modestly examined. Particularly, although Nrf2 shown to affect hematopoietic stem cells, it not tested bone marrow-derived cells (PACs). Here we investigated angiogenic properties of PACs, endothelial inflammation-related revascularization.Treatment with cytokines increased...
Heme oxygenase-1 (HMOX1) is a cytoprotective enzyme degrading heme to biliverdin, iron ions, and carbon monoxide, whose expression induced in response oxidative stress. Its overexpression has been suggested as strategy improving survival of transplanted muscle precursors.Here we demonstrated that HMOX1 inhibits differentiation myoblasts modulates miRNA processing: downregulates Lin28 DGCR8, lowers the total pool cellular miRNAs, specifically blocks induction myomirs. Genetic or...
Scope Ochratoxin A ( OTA ) is a mycotoxin exhibiting nephrotoxic and potential carcinogenic activity. We investigated the cross‐talk between micro RNA s, nuclear factor E 2‐related 2 N rf2), heme oxygenase‐1 HO ‐1) in ochratoxin ‐mediated effects. Methods results In porcine renal proximal tubular cells, increased expression of profibrotic transforming growth factors β TGF β) while concomitantly decreasing rf2, ‐1, erythropoietin. Adenoviral overexpression rf2 counteracted reduction ‐1...
Monocyte Chemoattractant protein-induced protein 1 (MCPIP1), also known as Regnase-1, is encoded by the ZC3H12a gene, and it mediates inflammatory processes regulating stability of transcripts coding for proinflammatory cytokines controlling activity transcription factors, such NF-κB AP1. We found that MCPIP1 transcript levels are strongly downregulated in clear cell renal carcinoma (ccRCC) samples, which were derived from patients surgically treated cancer compared to surrounded normal...
In order to gain a more comprehensive understanding of the aetiology apolipoprotein E4 genotype-cardiovascular disease (CVD) associations, impact apoE genotype on macrophage inflammatory response was examined. The murine monocyte-macrophage cell line (RAW 264.7) stably transfected produce equal amounts human apoE3 or apoE4 used. Following LPS stimulation, apoE4-macrophages showed higher and lower concentrations tumour necrosis factor alpha (pro-inflammatory) interleukin 10...
Through hypoxia-inducible factor 1 (HIF-1), hypoxia regulates the expression of numerous genes and is a potent inducer angiogenesis. However, interleukin-8 (IL-8), an important angiogenic mediator, has been reported to be downregulated by HIF-1, although mechanisms have not elucidated. HIF-1 was induced in human endothelial cells dimethyloxaloylglycine (DMOG). Interestingly, both DMOG attenuated IL-8 expression, similar effect obtained adenoviral overexpression stable form HIF-1alpha. Heme...
Recently we have shown that hypoxia as well overexpression of the stable form hypoxia-inducible factor-1α (HIF-1α) diminished expression interleukin-8 (IL-8) by inhibition Nrf2 transcription factor in HMEC-1 cells. Because HIF isoforms may exert different effects, aimed to examine influence HIF-2α on IL-8 endothelial In contrast HIF-1α, obtained adenoviral transduction resulted increased an Nrf2-independent way. Importantly, augmented activity SP-1, a involved regulation and known...
Abstract Rhabdomyosarcoma (RMS) is an aggressive soft tissue cancer characterized by disturbed myogenic differentiation. Here we report a role for the oxidative stress response factor HO-1 in progression of RMS. We found that was elevated and its effector target miR-206 decreased RMS cell lines clinical primary tumors more alveolar phenotype (aRMS). In embryonal (eRMS), expression induced Pax3/7-FoxO1, aRMS hallmark oncogene, followed drop levels. Inhibition tin protoporphyrin (SnPP) or...
Burkitt lymphoma (BL) is a rapidly growing tumor, characterized by high anabolic requirements. The MYC oncogene plays central role in the pathogenesis of this malignancy, controlling genes involved apoptosis, proliferation, and cellular metabolism. Serine biosynthesis pathway (SBP) couples glycolysis to folate methionine cycles, supporting certain amino acids, nucleotides, glutathione, methyl group donor, S-adenosylmethionine (SAM). We report that BLs overexpress SBP enzymes,...
Oxidative stress and the hypoxic microenvironment play a key role in progression of human melanoma, one most aggressive skin cancers. The aim our study was to evaluate effect Hypericum perforatum extracts different origins (both commercially available (HpEx2) laboratory-prepared from wild grown (HpEx12) vitro cultured (HpEx13) plants) hyperforin salt on WM115 primary WM266-4 lymph node metastatic melanoma cells under normoxic conditions. polyphenol content, radical scavenging activity,...