A5101535637- Genomics, phytochemicals, and oxidative stress
- Free Radicals and Antioxidants
- Moringa oleifera research and applications
- Phytochemicals and Antioxidant Activities
- Glutathione Transferases and Polymorphisms
- Nitrogen and Sulfur Effects on Brassica
- Bioactive Compounds and Antitumor Agents
- Plant pathogens and resistance mechanisms
- Advanced Glycation End Products research
- Curcumin's Biomedical Applications
- Biochemical Acid Research Studies
- Coenzyme Q10 studies and effects
- Biochemical effects in animals
- Biochemical and biochemical processes
- Insect Pest Control Strategies
- MicroRNA in disease regulation
- Synthesis and Biological Evaluation
- Sulfur Compounds in Biology
- Plant Disease Management Techniques
- Immune Cell Function and Interaction
- Synthesis and biological activity
- Pharmacological Effects of Natural Compounds
- Synthesis of Indole Derivatives
- Energy and Environment Impacts
- Garlic and Onion Studies
Fondazione Edmund Mach
2022-2024
Centro Agricoltura Ambiente (Italy)
2017-2020
Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria
2003-2018
Research Centre for Cereal and Industrial Crops
2007-2016
Université d'Orléans
2004-2009
Centre National de la Recherche Scientifique
2005-2009
Institut de Chimie Organique et Analytique
2005-2009
Laurentian University
2009
University of Bologna
2005-2008
Université de Rennes
2005
Rocket (Eruca sativa Mill. or Eruca vesicaria L.) is widely distributed all over the world and usually consumed fresh (leafs sprouts) for its typical spicy taste. Nevertheless, it mentioned in traditional pharmacopoeia ancient literature several therapeutic properties, does contain a number of health promoting agents including carotenoids, vitamin C, fibers, flavonoids, glucosinolates (GLs). The latter phytochemicals have recently gained attention as being precursors isothiocyanates (ITCs),...
There is high current interest in the chemopreventive potential of Brassica vegetables (cruciferae), particularly due to their content glucosinolates (GL), which upon myrosinase hydrolysis release corresponding isythiocyanates (ITC). Some ITCs, such as sulforaphane (SFN) from broccoli ( oleacea italica), have been found possess anticancer activity through induction apoptosis selected cell lines, well indirect antioxidant phase II detoxifying enzymes. Japanese daikon Raphanus sativus L.)...
Chronic inflammation and selenium deficiency are considered as risk factors for colon cancer. The protective effect of might be mediated by specific selenoproteins, such glutathione peroxidases (GPx). GPx-1 -2 double knockout, but not single knockout mice, spontaneously develop ileocolitis intestinal Since GPx2 is induced the chemopreventive sulforaphane (SFN) via nuclear factor E2-related 2 (Nrf2)/Keap1 system, susceptibility GPx2-KO wild-type (WT) mice to azoxymethane dextran sulfate...
Summary The authors assayed the ability of some reaction products, essentially isothiocyanates, derived from myrosinase‐catalysed hydrolysis (neutral pH) six natural glucosinolates to inhibit germination and mycelial growth Botrytis cinerea, Rhizopus stolonifer, Monilinia laxa, Mucor piriformis Penicillium expansum, leading postharvest fungal pathogens fruit vegetable crops. All tested products showed antifungal activity, although they proved less effective against than in control....
Nrf2 is a basic leucine zipper transcriptional activator essential for the coordinated induction of phase-2 and antioxidant enzymes. Brassica vegetables contain phytochemicals including glucoraphanin, precursor sulforaphane (SFN) glucobrassicin, indole-3-carbinole (I3C) ascorbigen (ABG). The degradation products SFN, I3C ABG may be capable inducing cytoprotective genes in skin. In this study, we tested potency affecting Nrf2-dependent gene expression human keratinocytes culture. SFN but not...
Glucoraphenin, a glucosinolate present in large quantities radish is hydrolysed by myrosinase to form the isothiocyanate sulforaphene, which believed be responsible for its chemopreventive activity; however, underlying mechanisms of action have not been investigated, particularly human cell lines. The aim study assess cytotoxicity sulforaphene HepG2 cells and evaluate potential enhance apoptosis. was carried out ensuing an initial screening with two other lines, MFC-7 HT-29, where displayed...
The beneficial effects of isothiocyanate‐based compounds, as well their safety, have been shown in neuropathological disorders, such neuropathic pain. Aim the present work was to study efficacy glucosinolate glucoraphanin (GRA) and derived isothiocyanate sulforaphane (SFN), secondary metabolites occurring exclusively Brassicales , on chemotherapy‐induced Mice were repeatedly treated with oxaliplatin (2.4 mg kg −1 ip) for 14 days induce GRA SFN evaluated after a single administration Day 15...
The fungitoxicity of allyl‐isothiocyanate (AITC) vapour against Penicillium expansum , the causal agent blue mould on pears (cvs Conference and Kaiser), was evaluated. best control obtained by exposing fruits for 24 h in a 5 mg L −1 AITC‐enriched atmosphere, extent depending inoculum density. Lesion diameter inversely related to AITC concentration. In treated percentage infected wounds increased with conidial concentration, fewer than 20% affected at 1 × 10 3 conidia mL almost 80% 6 ....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and identification for trans-4-(methylthio)-3-butenyl glucosinolate from radish roots (Raphanus sativus L.)Manuela. Visentin, Aldo. Tava, Renato. Iori, Sandro. PalmieriCite this: J. Agric. Food Chem. 1992, 40, 9, 1687–1691Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://doi.org/10.1021/jf00021a041RIGHTS & PERMISSIONSArticle Views800Altmetric-Citations96LEARN...
The most promising among glucosinolates (GLs) are those bearing in their aglycon an extra sulfur function, such as glucoraphasatin (4-methylthio-3-butenyl GL; GRH) and glucoraphenin (4-methylsulfinyl-3-butenyl GRE). GRE/GRH redox couple is typically met secondary metabolites of Raphanus sativus L. and, whereas GRE prevails seeds, GRH the major GL full-grown roots. During 10 days sprouting R. contents were determined according to Eurpean Union official method (ISO 9167-1). In comparison...
The reduced cancer risk that appears to be linked a diet rich in fruits and vegetables has fueled the belief regular intake of isolated phytochemicals could potentially prevent cancer. In recent years, glucosinolate metabolites derived from cruciferous vegetables, such as isothiocyanate sulforaphane broccoli, have gained much attention potential chemopreventive agents. protective effect sulforaphane, which is liberated its precursor glucoraphanin (GRP) by myrosinase hydrolysis,...