A5041211125- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Bone health and treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Advanced X-ray and CT Imaging
- Advanced Radiotherapy Techniques
- Immunotherapy and Immune Responses
- Medical Imaging and Pathology Studies
- Bone and Joint Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Management of metastatic bone disease
- Medical Image Segmentation Techniques
- Adrenal and Paraganglionic Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- AI in cancer detection
- MRI in cancer diagnosis
- Hematological disorders and diagnostics
- Ferroptosis and cancer prognosis
IQ Solutions
2021-2025
University of Wisconsin–Madison
2014-2022
University of Tennessee at Knoxville
2022
University of Wisconsin Carbone Cancer Center
2017-2020
Cancer Clinic
2017
National Cancer Institute
2017
Memorial Sloan Kettering Cancer Center
2017
Lung cancer, the most commonly diagnosed cancer worldwide, usually presents as solid pulmonary nodules (SPNs) on early diagnostic images. Classification of malignant disease at this timepoint is critical for improving success surgical resection and increasing 5-year survival rates. 18F-fluorodeoxyglucose (18F-FDG) PET/CT has demonstrated value SPNs diagnosis with high sensitivity to detect SPNs, but lower specificity in diagnosing populations endemic infectious lung disease. This study aimed...
<sup>18</sup>F-NaF, a PET radiotracer of bone turnover, has shown potential as an imaging biomarker for assessing the response metastases to therapy. This study aimed evaluate repeatability <sup>18</sup>F-NaF PET–derived SUV metrics in individual lesions from patients multicenter study. <b>Methods:</b> Thirty-five castration-resistant prostate cancer with multiple underwent 2 whole-body (test–retest) PET/CT scans 3 ± d apart 1 sites. A total 411 larger than 1.5 cm<sup>3</sup> were...
We previously reported the safety and immunologic effects of a DNA vaccine (pTVG-HP [MVI-816]) encoding prostatic acid phosphatase (PAP) in patients with recurrent, nonmetastatic prostate cancer. The current trial evaluated this on metastatic progression.Ninety-nine castration-sensitive cancer prostate-specific antigen (PSA) doubling time (DT) less than 12 months were randomly assigned to treatment either pTVG-HP co-administered intradermally 200 μg granulocyte-macrophage colony-stimulating...
Purpose [18F]Sodium fluoride (NaF) positron emission tomography (PET)/computed (CT) is a promising radiotracer for quantitative assessment of bone metastases. This study assesses changes in early NaF PET/CT response measures metastatic prostate cancer correlation to clinical outcomes. Patients and Methods Fifty-six patients with castration-resistant (mCRPC) osseous metastases had scans performed at baseline after three cycles chemotherapy (n = 16) or androgen receptor pathway inhibitors 40)....
18F-NaF PET/CT imaging of bone metastases is confounded by tracer uptake in benign diseases, such as osteoarthritis. The goal this work was to develop an automated lesion classification algorithm classify lesions NaF images.A nuclear medicine physician manually identified and classified 1751 images from 37 subjects with metastatic castrate-resistant prostate cancer, 14 which (598 lesions) were analyzed three additional physicians. Lesions on a five-point scale definite lesions....
Lung cancer usually presents as a solitary pulmonary nodule (SPN) on diagnostic imaging during the early stages of disease. Since diagnosis lung is very important for treatment, accurate SPNs has much importance. The aim this study was to evaluate discriminant power dual time point (DTPI) PET/CT in differentiation malignant and benign FDG-avid nodules by using neighborhood gray-tone difference matrix (NGTDM) texture features. Retrospective analysis carried out 116 patients with (35 81...
Standardized reporting of treatment response in oncology patients has traditionally relied on methods like RECIST, PERCIST and Deauville score. These endpoints assess only a few lesions, potentially overlooking the heterogeneity all disease. This study hypothesizes that comprehensive spatial-temporal evaluation individual lesions is necessary for superior prognostication clinical outcome.
Patients with metastatic neuroendocrine tumors (NETs) can present hundreds of lesions, and each lesion might have a unique response pattern to peptide receptor radiopharmaceutical therapy (PRRT). This heterogeneity has been observed but is poorly understood. In this work, we perform quantitative analysis longitudinal PET/CT scans comprehensively characterize the NET PRRT. <b>Methods:</b> patients treated [<sup>177</sup>Lu]Lu-DOTATATE PRRT imaged at baseline, during, after...
Objective.Patients with metastatic disease are followed throughout treatment medical imaging, and accurately assessing changes of individual lesions is critical to properly inform clinical decisions. The goal this work was assess the performance an automated lesion-matching algorithm in comparison inter-reader variability (IRV) matching between scans cancer patients.Approach.Forty pairs longitudinal PET/CT CT were collected organized into four cohorts: lung cancers, head neck lymphomas,...
Accurate registration over multiple scans is necessary to assess treatment response of bone diseases (e.g. metastatic lesions). This study aimed develop and evaluate an articulated algorithm for the whole-body skeleton in human patients. In registration, skeletons are registered by auto-segmenting into individual bones using atlas-based segmentation, then rigidly aligning them. Sixteen patients (weight = 80–117 kg, height 168–191 cm) with advanced prostate cancer underwent pre- mid-treatment...
Intrapatient treatment response heterogeneity is under-recognized. Quantitative total bone imaging (QTBI) using 18F-NaF positron emission tomography/computed tomography (PET/CT) scans a tool that allows characterization of interlesional in bone. Understanding spatial-temporal important to identify individuals who may benefit from beyond progression.Men with progressive metastatic castration-resistant prostate cancer (mCRPC) at least two lesions on scintigraphy were enrolled and treated...
Abstract Objective. Manual disease delineation in full-body imaging of patients with multiple metastases is often impractical due to high burden. However, this a clinically relevant task as quantitative image techniques assessing individual metastases, while limited, have been shown be predictive treatment outcome. The goal work was evaluate the efficacy deep learning-based methods for skeletal and compare their performance existing terms accuracy prognostic power. Approach. 1833 suspicious...
Identification of individual lesions on 18F-NaF PET bone scans is a time-consuming and often subjective process that makes accurate characterization disease burden challenging. Current automated methods either underestimate or struggle with high false positive rates. We developed statistically optimized regional thresholding (SORT) method optimizes detection lesions. This study assessed PET/CT 37 metastatic prostate cancer patients. Each image was divided into 19 skeletal regions. Areas in...
Metastatic cancer presents with many, sometimes hundreds of metastatic lesions through the body, which often respond heterogeneously to treatment. Therefore, lesion-level assessment is necessary for a complete understanding disease response. Lesion-level typically requires manual matching corresponding lesions, tedious, subjective, and error-prone task. This study introduces fully automated algorithm in longitudinal medical images. The entails four steps: (1) image registration, (2) lesion...
Despite the systemic impact of both cancer and associated immune response, immuno-PET is predominantly centered on assessment milieu within tumor microenvironment. The aim this study was to assess value [<sup>18</sup>F]F-AraG PET imaging as a noninvasive method for evaluation system-wide status patients with non–small cell lung before starting immunotherapy. <b>Methods:</b> Eleven advanced were imaged Diagnostic [<sup>18</sup>F]FDG PET/CT scans analyzed differences in extent disease among...
Objective. Automated organ segmentation on CT images can enable the clinical use of advanced quantitative software devices, but model performance sensitivities must be understood before widespread adoption occur. The goal this study was to investigate differences between Convolutional Neural Networks (CNNs) trained segment one (single-class) versus multiple (multi-class) organs, and CNNs scans from a single manufacturer manufacturers.Methods. multi-class CNN obtained 455 whole-body PET/CT...
ACRIN 6687, a multi-center clinical trial evaluating differential response of bone metastases to dasatinib in men with metastatic castration-resistant prostate cancer (mCRPC), used [18F]-fluoride (NaF) PET imaging. We extend previous 6687 dynamic imaging results by examining NaF whole-body (WB) static SUV scans acquired after scanning. Eighteen patients underwent WB prior and 12 weeks into treatment. Regional VOI analysis the most avid an automated method using Quantitative Total Bone...
Purpose: Clinical use of 18 F‐Sodium Fluoride (NaF) PET/CT in metastatic settings often lacks technology to quantitatively measure full disease dynamics due high tumor burden. This study assesses radiomics‐based extraction NaF measures, including global metrics overall burden and local heterogeneity, prostate cancer for correlation clinical outcomes. Methods: Fifty‐six Castrate‐Resistant Prostate Cancer (mCRPC) patients had scans performed at baseline three cycles into chemotherapy (N=16) or...
180 Background: CRPC is frequently associated with the development of osseous metastases. While imaging allows treatment response determination in soft tissue metastasis, its application bony metastasis limited to staging. Methods: QTBI an innovative tool that extraction comprehensive functional information all metastases, as well individual lesions, using 18 F-Sodium Fluoride (NaF) PET/CT. We completed a multi-center trial assessing performance characteristics (test-retest) and...