A5002952202- Global Maritime and Colonial Histories
- Advanced Thermodynamic Systems and Engines
- Historical and Cultural Studies of Poland
- Mast cells and histamine
- Hypertrophic osteoarthropathy and related conditions
- Smoking Behavior and Cessation
- African Studies and Geopolitics
- Alcoholism and Thiamine Deficiency
- Immunotherapy and Immune Responses
- Neurological diseases and metabolism
- Pharmaceutical Economics and Policy
- Polish Historical and Cultural Studies
- Nicotinic Acetylcholine Receptors Study
- Superconducting Materials and Applications
- Pharmaceutical studies and practices
- Chinese history and philosophy
- Pediatric Pain Management Techniques
- Treatment of Major Depression
- Language and Culture
- Cytomegalovirus and herpesvirus research
- Heterotopic Ossification and Related Conditions
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Neonatal Health and Biochemistry
- Renal cell carcinoma treatment
University of Chicago
2022-2024
Presbyterian Hospital
2022
Cornell University
2022
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2019
Gilead Sciences (United States)
2007-2009
Hershey (United States)
2009
Cancer Research Foundation
2009
Lockheed Martin (United States)
2005
University of California, San Francisco
1990-2000
GS-9219, a novel prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG), was designed as cytotoxic agent that preferentially targets lymphoid cells. Our objective to characterize antiproliferative activity, pharmacokinetics, pharmacodynamics, and safety GS-9219.GS-9219 selected through screening in proliferation assays pharmacokinetic screening. The activation pathway GS-9219 characterized lymphocytes, its activity evaluated against panel hematopoietic nonhematopoietic...
ABSTRACT GS-9191 is a novel double prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine (PMEG) designed as topical agent to permeate skin and be metabolized active nucleoside triphosphate in epithelial layer. The was shown intracellularly 9-(2-phosphonylmethoxyethyl)-N 6 -cyclopropyl-2,6,diaminopurine (cPrPMEDAP) subsequently deaminated PMEG. form, PMEG diphosphate, potent inhibitor DNA polymerase α ß while showing weaker activity against mitochondrial γ (50% enzyme...
The accumulated data on the glycation process in rhDNase I, formulated with lactose and stored dry-powder state, indicates that this protein becomes covalently modified at five of six lysines (2, 50, 77, 157, 260) to a lesser extent amino terminus. Analysis three-dimensional structure reported requirements for specificity site reactivity, accessibility, presence proton donor/acceptor group near reaction site, are maintained protein. A chemical state may become permissible simply due close...
The Wide-Field Infrared Survey Explorer (WISE) is a MIDEX mission that being developed by the Jet Propulsion Laboratory (JPL) to address several of NASA's Astronomical Search Origins (ASO) objectives. WISE instrument, Space Dynamics (SDL), includes cryogenically cooled telescope (at < 13K) and four focal plane assemblies (2 at 7.6K, 2 32K). Cooling instrument accomplished dual-stage solid hydrogen cryostat Lockheed Martin Advanced Technology Center (LM-ATC). This paper provides combined...
The Holy Islamic Tomb at Lingshan Mountain in Quanzhou, China, is believed to be the final resting place of two Prophet Muhammad’s disciples who were dispatched as missionaries early seventh century. While prior scholarship has centred on verifying tradition’s chronology, this article foregrounds role environmental actors tomb site’s ascent prominence. I argue that holy ( shengmu ) tradition did not emerge until late sixteenth and seventeenth century, so its invention should analysed...
Dasatinib is the second-generation tyrosine kinase inhibitor used in treatment of chronic myeloid leukemia. Proteinuria has been reported with this agent. We describe two kidney biopsy–proven cases dasatinib-induced thrombotic microangiopathy that responded to stoppage dasatinib and using an alternate inhibitor. Certain specific inhibitors lead endothelial injury renal-limited microangiopathy. Hematologists nephrologists need be familiar off-target effect dasatinib.
Journal of the American Society Nephrology 33(11S):p 904, November 2022. | DOI: 10.1681/ASN.20223311S1904c