A5058603721- Microbial Inactivation Methods
- Microfluidic and Bio-sensing Technologies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Melanoma and MAPK Pathways
- Listeria monocytogenes in Food Safety
- Neuroendocrine Tumor Research Advances
- Toxin Mechanisms and Immunotoxins
- Gastric Cancer Management and Outcomes
- Radiopharmaceutical Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Plasma Applications and Diagnostics
- Ultrasound and Hyperthermia Applications
- Cancer Treatment and Pharmacology
- Vascular Procedures and Complications
- Infectious Aortic and Vascular Conditions
- Protein Degradation and Inhibitors
- Chromatin Remodeling and Cancer
- Central Venous Catheters and Hemodialysis
- Intraperitoneal and Appendiceal Malignancies
- Mechanisms of cancer metastasis
- Microbial infections and disease research
Institute of Oncology Ljubljana
2013-2024
University of Primorska
2020
Abstract Background Immune checkpoint inhibitors have changed the paradigm of cancer treatment; however, non-invasive biomarkers response are still needed to identify candidates for non-responders. We aimed investigate whether immunotherapy [ 18 F]FDG PET radiomics signature (iRADIOMICS) predicts metastatic non-small-cell lung (NSCLC) patients pembrolizumab better than current clinical standards. Patients and methods Thirty receiving were scanned with PET/CT at baseline, month 1 4....
Abstract The first clinical studies on the use of electrochemotherapy to treat liver tumours that were not amenable surgery or thermal ablation techniques have recently been published. However, there is still a lack data effects normal tissue. Therefore, we designed translational animal model study test whether with bleomycin causes clinically significant damage tissue, emphasis large blood vessels and bile ducts. We performed delivered electric pulses alone using potentially risky treatment...
A previous pilot study proved the feasibility, safety and efficacy of electrochemotherapy in treatment colorectal liver metastases. The aim this was to evaluate long-term effectiveness unresectable metastases.In prospective phase II study, patients with metachronous metastases were included. In all patients, at least one metastasis due its central location or a too-small future remnant volume. Patients treated by using intravenously administered bleomycin during open surgery. Treated 84 39...
Abstract Background The aim of the study was to characterize ultrasonographic (US) findings during and after electrochem-otherapy liver tumors determine actual ablation zone verify coverage treated tumor with a sufficiently strong electric field for effective electrochemotherapy. Patients methods US from two representative patients that describe immediate delayed changes electrochemotherapy colorectal metastases are presented. Results were interrelated magnetic resonance imaging (MRI)....
Abstract Background Radiologic findings after electrochemotherapy of large hepatic blood vessels and healthy parenchyma have not yet been described. Materials methods We performed a prospective animal model study with regulatory approval, including nine grower pigs. In each animal, four ultrasound-guided electroporated regions were created; in three regions, electrodes inserted into the lumen vessels. Two types tested; variable linear- fixed hexagonal-geometry electrodes. Ultrasonographic...
For locally advanced rectal cancer (LARC), standard therapy [consisting of neoadjuvant chemoradiotherapy (CRT), surgery, and adjuvant chemotherapy (ChT)] achieves excellent local control. Unfortunately, survival is still poor due to distant metastases, which remains the leading cause death among these patients. In recent years, concept total treatment (TNT) has been developed, whereby all systemic ChT-mainly affecting micrometastases-is applied prior surgery.To compare for LARC patients with...
Objectives The use of thermal ablative therapies in the pancreatic tumors is limited because risk vessel injury and potential pancreatitis or fistula formation. Electrochemotherapy (ECT) an therapy with established role treatment cutaneous liver tumors. This study was designed to evaluate safety feasibility ECT pancreas a porcine survival model. Methods In first group, 4 animals underwent computed tomography (CT)–guided percutaneous bleomycin tail. second group (4 animals), intraoperative...
Abstract Background In the light of a high rate distant recurrence and poor compliance adjuvant chemotherapy in risk rectal cancer patients total neoadjuvant treatment was logical approach to gaining acceptance. We aimed evaluate toxicity efficiency this with factors for local or recurrence. Patients methods stage II III at least one factor: T4, presence extramural vein invasion (EMVI), positive extramesorectal lymph nodes mesorectal fascia (MRF) involvement were treated four cycles...
Endoscopic colorectal tattooing with carbon-based dyes is commonly employed in order to assist later localization of the lesion. Although carbon thought be nontoxic, there usually some inflammatory reaction fibrosis and granuloma formation after tissue injection. The aim this report alert a possible underestimated, late consequence marker tattooing, namely pronounced at site injection that could lead blurring misinterpretation changes evaluated by radiological techniques. We describe case cT...
Abstract BAP1 cancer syndrome is a rare and highly penetrant hereditary predisposition. Uveal melanoma, mesothelioma, renal cell carcinoma (RCC) cutaneous melanoma are considered core cancers, whereas association with breast has previously been suggested but not confirmed so far. In view of immunomodulatory functions, alterations could prove useful as possible biomarkers response to immunotherapy in patients BAP1-associated cancers. We present case patient who developed metastatic loss...
Background: The introduction of stent grafts for thoracic and abdominal aorta (T / EVAR) has raised the demand percutaneous closure devices larger femoral arterial access sites. aim our study was to evaluate success complication rate completely T EVAR with Prostar XL® surgical haemostasis over a 50- month period. Patients methods: Between December 16th 2005 February 17th 2010 performed in 306 patients 568 sites diameters 12 24 Fr. exclusion criteria were calcified anterior wall at puncture...
Electrochemotherapy (ECT) and/or gene electrotransfer of plasmid DNA encoding interleukin-12 (GET pIL-12) are effective treatments for canine cutaneous, subcutaneous, and maxillofacial tumors. Despite the clinical efficacy combined ECT GET, data on parameters that might predict outcome still lacking. This study aimed to investigate whether dynamic contrast-enhanced ultrasound (DCE-US) results subcutaneous tumors differ between with complete response (CR) without (non-CR) in dogs treated GET...
This case report presents a patient with metastatic malignant melanoma who was treated immunotherapy the PD-1 checkpoint inhibitor pembrolizumab and developed rare neurological immune-related adverse event (irAE) limbic encephalitis. Despite successful treatment of irAE, deficit persisted. With this article, we would like to make all physicians aware but serious irAE that can occur at any time during inhibitor.
Due to a lack of data on predictors electroporation-based treatment outcomes, we investigated the potential predictive role contrast-enhanced harmonic ultrasound (CEUS) in mice B16F10 melanoma treated by gene electrotransfer (GET) silence cell adhesion molecule (MCAM) and radiotherapy, which has not been evaluated yet. CEUS evaluation was verified tumor histological analysis. Mice bearing subcutaneous tumors were with GET MCAM, irradiation or combination MCAM (combined treatment). used...
Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant of the central nervous system, ussually diagnosed in children less than 5 years age. ATRT rarely found adults with average survival these patients two years. Treatment regimens are often extrapolated from pediatric experience and modified according to characteristics. Here we present case 35-year-old right-handed woman metastatic brain first seen at our institution march 2016. She complained on three months lasting loose...
Patients with peritoneal carcinomatosis have a poor prognosis despite multimodal treatment surgery and chemotherapy. Cytoreductive is the only curative option for of but minority patients are eligible surgical treatment. For non-resectable carcinomatosis, chemotherapy possible limited effect on metastases due to vascularization low penetration drug. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) new minimally invasive method using laparoscopy deliver in form pressurized aerosol...