A5065344185- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Ginseng Biological Effects and Applications
Xuzhou Medical College
2020-2022
Background The underlying mechanisms of neuropathic pain remain unclear. This work aimed to investigate the role Sirtuin3 (SIRT3), an nicotinamide adenosine dinucleotide+-dependent histone deacetylase, in development induced by type 2 diabetes mellitus (T2DM) and explore associated mechanisms. Methods Diabetic (DNP) rats was high-fat diet/low-dose streptozotocin. behaviors were examined using von Frey Hargreaves tests. levels SIRT3, manganese superoxide dismutase (MnSOD) catalase (CAT)...
Numerous studies have shown that mitochondrial dysfunction manifested by increased permeability transition pore (mPTP) opening and reactive oxygen species (ROS) level, decreased membrane potential (MMP) plays an important role in the development of neuropathic pain. Sirtuin3 (SIRT3), a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase, has been to inhibit oxidative stress. However, SIRT3 pain is unclear. In this study, we found protein mRNA levels were significantly...
Long-term chronic pain can lead to depression. However, the mechanism underlying pain-related depression remains unclear. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase (HDAC). Our previous studies have demonstrated that SIRT1 in central nucleus of amygdala (CeA) involved development In addition, increasing indicated long non-coding RNAs (lncRNAs) play vital role pathogenesis or whether lncRNAs are SIRT1-mediated largely unknown. this study, we...