A5101842010- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Effects of Radiation Exposure
- Genomics and Chromatin Dynamics
- Genetic Syndromes and Imprinting
- Congenital Heart Disease Studies
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
- Chemokine receptors and signaling
- RNA modifications and cancer
- Cancer survivorship and care
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Cancer-related Molecular Pathways
- Protein Degradation and Inhibitors
- Tissue Engineering and Regenerative Medicine
- Lung Cancer Treatments and Mutations
- interferon and immune responses
Harbin Medical University
2011-2023
Third Affiliated Hospital of Harbin Medical University
2011-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Shanghai Medical College of Fudan University
2020
South Central Minzu University
2016
Affiliated Hospital of Chengde Medical College
2012
University of California, Irvine
2004
TBX3 is a transcription factor of the T-box gene family. Mutations cause ulnar-mammary syndrome (MIM 181450) in humans, an autosomal dominant disorder characterized by absence or underdevelopment mammary glands and other congenital anomalies. It recently was found that able to immortalize mouse embryo fibroblast (MEF) cells. In addition, TBX2, homologue TBX3, active preventing senescence rodent cells be amplified some human breast cancers, suggesting plays role cancer. This study examined...
The fatigue prevalence in breast cancer survivors is high during the endocrine treatment. However, there are few evidence-based interventions to manage this symptom. aim of study was investigate effectiveness spore powder Ganoderma lucidum for cancer-related patients undergoing therapy. Spore a kind Basidiomycete which widely used traditional medicine China. 48 with therapy were randomized into experimental or control group. FACT-F, HADS, and EORTC QLQ-C30 questionnaires data collected at...
Cancer stem cells are enriched in triple-negative breast cancer (TNBC) tumor tissues, which present strong capacities of proliferation and tumorigenicity. The study detected the distribution cell markers cluster differentiation (CD)44/CD24 analyzed clinical outcomes different CD44/CD24 phenotypes patients with TNBC. Multivariate Cox regression analyses were performed regard to prognostic value CD44/CD24, aldehyde dehydrogenase 1 other baseline characteristics, including size, lymph node...
Introduction: There is limited information on elderly patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infections. We aimed to describe the characteristics and outcomes of infections admitted intensive care unit (ICU) Chinese Mainland evaluate risk factors associated mortality in these patients. Methods: conducted a multicenter retrospective study including SARS-CoV-2 infection who were ICU from November 1, 2022, February 11, 2023, Mainland. The...
// Guangwen Shu 1 , Lang Zhang Shanqing Jiang Zhuo Cheng Guan Wang Xu Huang Xinzhou Yang School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, PR China Correspondence to: Yang, email: xinzhou_yang@163.com Keywords: isoliensinine, hepatocellular carcinoma, PP2A, I2PP2A, NF-κ B Received: February 15, 2016 Accepted: April 26, Published: May ABSTRACT Our previous study discovered that isoliensinine (isolie) triggers carcinoma (HCC) cell apoptosis via inducing p65...
Mixed-lineage leukemia 1 (MLL1), which exerts its H3K4 methyltransferase activity by interacting with WDR5, ASH2L, and RBBP5, plays a pivotal role in regulating hematopoietic stem cell homeostasis. Disrupting the integrity of MLL1-complex has been reported to be associated acute leukemia. However, exact myeloid cells is unknown. In this study, microarray analysis revealed that core components Mll1-complex, Wdr5, Ash2l, Mll1, were concurrently downregulated tumor-secreted factors as well...
Abstract TBX5 is a member of the T‐box gene family and encodes transcription factor that regulates expression other gene(s) in developing heart limbs. Mutations cause Holt–Oram syndrome (HOS), an autosomal dominant condition characterized by congenital defects limb anomalies. How regulated still largely unknown. In order to identify factors regulating expression, we examined 5′‐flanking region human gene. We determined up 300 bp was necessary for promoter activity mouse cardiomyocyte ECL2...
As a selective histone deacetylase (HDAC) inhibitor developed in China, chidamide has been applied for the treatment of refractory peripheral T-cell lymphoma (PTCL) and multiple solid tumors, including lung cancer. However, underlying mechanisms are not well elucidated. In our present study, we found that radiation acted synergistically to suppress cell xenograft growth squamous carcinoma cells by inducing apoptosis. Moreover, alone or combination inhibited cancer stemness. miRNA microarray...
We determined whether the coexpression of Notch1 and EZH2 influences progression prognosis breast invasive ductal carcinoma.Using c 2 test, a significant difference was found between high low expression in terms lymph node, hormone receptor, p53 (P < 0.05).Moreover, tumor size, histologic grade, Ki67 0.05).Using Pearson correlation analysis, we positive tissue samples carcinoma = 0.038).High associated with poor progression-free survival compared 0.000, 40.3 vs 48.9 months; P 40.2 49.9...
Although all murine MDSCs are defined as Gr1+CD11b+, their true immunophenotype remains elusive. In this study, we found Gr1+CD11b+ cells can be divided into two subsets: Gr1+CD11b+B220− and Gr1+CD11b+B220+, especially in the spleen tissues. Unlike dominant B220− subset, B220+ subpopulation was not induced by tumor vivo. Moreover, Gr1+CD11b+B220+ from tumor-bearing mice spleens were unable to induce arginase 1 inducible nitric oxide synthase expression, inhibit T cell proliferation, or...