A5022985603- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Virus-based gene therapy research
- Paraoxonase enzyme and polymorphisms
- Genetic factors in colorectal cancer
- Genetics, Aging, and Longevity in Model Organisms
- Immune Cell Function and Interaction
- Health, Environment, Cognitive Aging
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Genetics, Bioinformatics, and Biomedical Research
- RNA and protein synthesis mechanisms
- Bioinformatics and Genomic Networks
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA regulation and disease
- Viral gastroenteritis research and epidemiology
- Gene expression and cancer classification
- Machine Learning in Bioinformatics
- Pancreatic and Hepatic Oncology Research
- Animal Disease Management and Epidemiology
Shandong University
2024
Personalis (United States)
2024
Cofactor Genomics (United States)
2020
George Mason University
2014-2019
Tiande (China)
2016
Rutgers, The State University of New Jersey
2014
// Josette Northcott 1 , Gabor Bartha Jason Harris Conan Li Fabio C.P. Navarro Rachel Marty Pyke Manqing Hong Qi Zhang Shuyuan Ma Tina X. Chen Janet Lai Nitin Udar Juan-Sebastian Saldivar Erin Ayash Joshua Anderson Jiang Tiange Cui Tu Le Ruthie Chow Randy Jerel Velasco Chris Mallo Rose Santiago Robert C. Bruce Laurie J. Goodman Yi Dan Norton Richard O. * and John M. Lyle Personalis, Inc., Fremont, CA 94555, USA Co-last authors Correspondence to: Lyle, email: john.lyle@personalis.com...
Human adenoviruses (HAdVs) are uniquely important "model organisms" as they have been used to elucidate fundamental biological processes, recognized complex pathogens, and remedies for human health. As HAdVs may effect asymptomatic or mild severe symptomatic disease upon their infection of respiratory, ocular, gastrointestinal, genitourinary systems. High-resolution genomic data enhanced the understanding HAdV epidemiology, with recombination an major pathway in molecular evolution genesis...
As immuno-oncology drugs grow more popular in the treatment of cancer, better methods are needed to quantify tumor immune cell component determine which patients most likely benefit from treatment. Methods such as flow cytometry can accurately assess composition infiltrating cells; however, they show limited use formalin-fixed, paraffin-embedded (FFPE) specimens. This article describes a novel hybrid-capture RNA sequencing assay, ImmunoPrism, that estimates relative percentage abundance...
RNA-related applications of the next-generation sequencing (NGS) technologies require context-specific interpretations: e.g., sequence mismatches may indicate sites RNA editing, or uneven read coverage often points to mature form microRNA. Existing visualization tools traditionally show molecules in two dimensions, with their base pairing and resulting secondary structure. However, it is not straightforward combine a linear NGS data display 2-D depictions. We present novel approach for...
Typically, gene expression biomarkers are being discovered in course of high-throughput experiments, for example, RNAseq or microarray profiling. Analytic pipelines that extract so-called signatures suffer from the "Dimensionality curse": number genes expressed exceeds patients we can enroll study and use to train discriminator algorithm. Hence, problems with reproducibility more common than not; when algorithm is executed using a different training set, resulting diagnostic signature may...
The highly deadly illness known as cancer is brought on by the malignant growth of cells, and it ranks among top causes death globally at moment.In recent years, research treatment drugs has emerged one after another. However, due to continuous mutation they develop resistance traditional anti-cancer drugs, making even more difficult achieve a complete cure for cancer.Recent experimental studies have shown that ferroptosis,a non-apoptotic cell pathway triggered iron, can effectively overcome...
ABSTRACT We describe the analytical validation of NeXT Personal ® , an ultra-sensitive, tumor-informed circulating tumor DNA (ctDNA) assay for detecting residual disease, monitoring therapy response, and recurrence in patients diagnosed with solid cancers. uses whole genome sequencing matched normal samples combined advanced analytics to accurately identify up ∼1,800 somatic variants specific patient’s tumor. A personalized panel is created, targeting these then used sequence cell-free...
High density lipoprotein associated cholesterol (HDL-C) has been the traditional biomarker for estimating cardiovascular protection derived from HDL; however, several recent studies have made it clear that HDL-C may not necessarily represent protective capacity of HDL. The diverse protein and lipid content HDL is becoming increasingly recognized as basis functional complexity observed in these particles. Proteomics identified 95 consensus proteins consistently found to associate with For...