A5005657635- Inflammatory Myopathies and Dermatomyositis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nanoplatforms for cancer theranostics
- Nanocomposite Films for Food Packaging
- Amyotrophic Lateral Sclerosis Research
- Polymer Surface Interaction Studies
- Parkinson's Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
- Nanoparticle-Based Drug Delivery
- Alzheimer's disease research and treatments
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Diet and metabolism studies
- Hemostasis and retained surgical items
- Liver Disease Diagnosis and Treatment
- Crystal structures of chemical compounds
- Advanced Nanomaterials in Catalysis
- Nerve injury and regeneration
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Advanced biosensing and bioanalysis techniques
- Plant-derived Lignans Synthesis and Bioactivity
- Hydrogels: synthesis, properties, applications
- Ruminant Nutrition and Digestive Physiology
- Adipose Tissue and Metabolism
Qilu Hospital of Shandong University
2015-2025
Shandong University
2018-2024
Heilongjiang Academy of Sciences
2024
Center for Excellence in Molecular Plant Sciences
2017-2021
Chinese Academy of Sciences
2017-2021
Soochow University
2021
First Affiliated Hospital of Soochow University
2021
Qingdao Center of Resource Chemistry and New Materials
2021
Shanghai Institutes for Biological Sciences
2017-2020
The University of Texas Medical Branch at Galveston
2020
The incidence of nonalcoholic fatty liver disease (NAFLD) in postmenopausal women has increased significantly. Estrogen plays a very important role NAFLD, but whether NAFLD premenopausal was caused by estrogen deficiency unknown. Thus, it is great clinical significance to explore the mechanism women. Gut microbiota and its metabolites short chain acids (SCFA) have been shown play roles development NAFLD. In this study, we investigated impact gut SCFA patients mice deficiency. We showed that...
Abstract Intracellular zinc ion (Zn 2+ ) accumulation disrupts the Zn homeostasis, providing an ion‐overloading anticancer strategy with great potential. The self‐adaptation of tumor cells to concentration, however, puts forward higher requirements for design strategy. Herein, “block and attack” antitumor was applied through a composite nanomaterials (UHSsPZH NPs). demonstrated powerful interference ability both “blocking” efflux excess via gene silencing “attacking” target delivery ZnO 2 ....
Abstract Recently, non-thermal plasma (NTP) technologies have found widespread application across diverse fields, including plant growth, medical science, and biological environmental research. Rice ( Oryza sativa L. ) is exceptionally sensitive to temperature changes. Notably, low-temperature stress primarily affects the germination reproductive stages of rice, often leading reduced crop yield. This study aimed identify optimal conditions for enhancing rice seed seedling growth under low...
CMH-OBN nano-platform was designed for the ROS/GSH dual-responsive release of nitric oxide at tumor site realizing multi-modal therapy.
Using in vivo neuroimaging techniques, growing evidence has demonstrated that the choroid plexus (CP) volume is enlarged patients with several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. However, although animal postmortem findings suggest CP abnormalities are likely important pathological mechanisms underlying amyotrophic lateral sclerosis (ALS), third most common disease, no available study been conducted to thoroughly assess their clinical relevance...
Diacetyl chitin (DAC) is an acidylated obtained using acetic anhydride mixed perchloric acid system. By wet spinning and weaving technique, DAC has been successfully developed into a novel absorbable surgical suture. Thanks to the unique properties of chitins, potential application this monocomponent multifilament suture may break monopoly synthetic polymer sutures in wound closure area. In study, was synthesized characterized by multiple approaches including elemental analysis, Fourier...
In this study, an efficient composite hemostatic material (DA-diatom-T) was prepared, using a polydopamine layer as linker to immobilize thrombin on the surface of diatom biosilica.
Abstract The higher prevalence of metabolic syndrome (MetS) in women after menopause is associated with a decrease circulating 17β-oestradiol. To explore novel treatments for MetS oestrogen deficiency, we studied the effect exogenous butyrate on diet-induced obesity and dysfunctions using ovariectomized (OVX) mice as model. Oral administration sodium (NaB) reduced body fat content blood lipids, increased whole-body energy expenditure, improved insulin sensitivity. Additionally, NaB induced...
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of dermatomyositis, potentially triggered by viral infection (Lu et al., 2024). We generated and characterized human induced pluripotent stem cell (hiPSC) line from skin fibroblasts patient with MDA5-DM. Their pluripotency was demonstrated the expression multiple markers on RNA levels, as well their ability to differentiate into all three germ layers.
Endometrial cancer (EC) is one of the most common malignant gynecological tumors in women. The main treatments for EC (surgery, chemotherapy and radiation therapy) produce significant side effects. Thus, it urgent to identify promising therapeutic targets prognostic markers. CACNA2D3, as a member calcium channel regulatory α2δ subunit family, reported exert tumor suppressive effect numerous cancers. However, function CACNA2D3 not well known. In present study, was lowly expressed tissues...
Abstract Dysfunction of the calcium balancing system and disruption distribution can induce abnormal intracellular overload, further causing serious damage even cell death, which provides a potential therapeutic approach for tumor treatment. Herein, nano‐platform, includes UCNPs‐Ce6@RuR@mSiO 2 @PL‐HA NPs (UCRSPH) SA‐CaO nanoparticles, is prepared improving micro‐environment (TME), Ca 2+ signal disturbance as well enhanced photodynamic therapy (PDT). UCRSPH combined with alter TME relieve...
Pinoresinol-lariciresinol reductases (PLRs) are enzymes involved in the lignan biosynthesis after initial dimerization of two monolignols, and this represents entry point for synthesis 8-8' lignans contributes greatly to their structural diversity. Of particular interest has been determination how differing substrate specificities achieved with these enzymes. Here, we present crystal structures IiPLR1 from Isatis indigotica pinoresinol (PrRs) AtPrR1 AtPrR2 Arabidopsis thaliana, apo,...
Anti-mitochondrial antibodies, the hallmark of primary biliary cirrhosis, have been detected in many patients with idiopathic inflammatory myopathies and these anti-mitochondrial-antibody-associated frequently show unique characteristics. We anti-mitochondrial antibodies Chinese myopathy summarized clinical findings anti-mitochondrial-antibody-positive patients. Of 136 patients, seven (5.15%) were found to be anti-mitochondrial-antibody-positive. Primary cirrhosis was present 2 7 chronic...