A5082809821- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Immune cells in cancer
- Acute Myocardial Infarction Research
- Advanced Radiotherapy Techniques
- Hepatitis B Virus Studies
- Head and Neck Cancer Studies
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Circular RNAs in diseases
- Vaccine Coverage and Hesitancy
- Epigenetics and DNA Methylation
- Dermatological and COVID-19 studies
- Influenza Virus Research Studies
- Microtubule and mitosis dynamics
- Cancer, Lipids, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
Shihezi University
2022-2025
First Affiliated Hospital of Shihezi University Medical College
2024-2025
National Vaccine and Serum Institute
2021-2024
Southwest Jiaotong University
2022-2024
Chengdu Third People's Hospital
2022-2024
Zhongshan Hospital
2022-2023
Fudan University
2022-2023
Sun Yat-sen University
2022-2023
The First Affiliated Hospital, Sun Yat-sen University
2022-2023
Chinese PLA General Hospital
1992-2022
Recently, attention has been focused on the central role of TREM2 in diverse pathologies. However, signaling tumor microenvironment hepatocellular carcinoma (HCC) remains poorly understood. Herein, we systematically investigated single-cell transcriptomes human HCC tissues and found that was predominantly expressed by a macrophage subpopulation enriched resemble lipid-associated macrophages (LAMs). The accumulation TREM2+ LAM-like cells confirmed two additional cohorts using scRNA-seq...
Aurora A plays a critical role in G2/M transition and mitosis, making it an attractive target for cancer treatment. inhibitors showed remarkable antitumor effects preclinical studies, but unsatisfactory outcomes clinical trials have greatly limited their development. In this study, the inhibitor alisertib upregulated PD-L1 expression panel of tumor cells both vitro vivo. The upregulation checkpoint protein reduced immunity immune-competent mice, paradoxically inhibiting alisertib....
Abstract Prostate cancer (PCa) is the second most prevalent malignancy in males across world. A greater knowledge of relationship between protein abundance and drug responses would benefit precision treatment for PCa. Herein, we establish 35 Chinese PCa primary cell models to capture specific characteristics among patients, including gene mutations, mRNA/protein/surface distributions, pharmaceutical responses. The multi-omics analyses identify Anterior Gradient 2 (AGR2) as a pre-operative...
Abstract NVSI-06-08 is a potential broad-spectrum recombinant COVID-19 vaccine that integrates the antigens from multiple SARS-CoV-2 strains into single immunogen. Here, we evaluate safety and immunogenicity of as heterologous booster dose in BBIBP-CorV recipients randomized, double-blind, controlled, phase 2 trial conducted United Arab Emirates (NCT05069129). Three groups healthy adults over 18 years age (600 participants per group) who have administered two doses 4-6-month, 7-9-month...
The continuous emergence of SARS-CoV-2 variants highlights the need developing vaccines with broad protection. Here, according to immune-escape capability and evolutionary convergence, representative strains carrying hotspot mutations were selected. Then, guided by structural computational analyses, we present a mutation-integrated trimeric form spike receptor-binding domain (mutI-tri-RBD) as broadly protective vaccine candidate, which combined heterologous RBDs from different into hybrid...
It is now well established that parenteral drug abuse a significant risk factor for contracting human immunodeficiency virus type 1 (HIV-1) infection and subsequently developing AIDS. Earlier studies have shown morphine can modulate various immune responses therefore support the premise cofactor in susceptibility to progression of HIV infection. Dysregulation interferon (IFN) production, nonspecific apoptosis T cells, response soluble gene products been associated with potential mechanisms...
COVID-19 is a severe disease in humans, as highlighted by the current global pandemic. Several studies about metabolome of patients have revealed metabolic disorders and some potential diagnostic markers during progression. However, longitudinal changes metabolomics patients, especially their association with progression, are still unclear. Here, we systematically analyzed dynamic serum demonstrating that most metabolites did not recover 1-3 days before discharge. A prominent signature...
The Global Registry of Acute Coronary Events (GRACE) score derived from clinical parameters at the time hospital discharge is a powerful predictor long-term mortality and reinfarction after acute coronary syndrome (ACS). triglyceride glucose (TyG) index, which simple reliable surrogate marker insulin resistance, has been demonstrated to be an independent adverse major cardiac events, irrespective diabetes mellitus. We investigate whether addition TyG index improves predictive ability GRACE...
Abstract Background The residual SYNTAX score (rSS), a quantitative measure of angiographic completeness revascularization after percutaneous coronary intervention (PCI), and the triglyceride–glucose index (TyG index), reliable surrogate marker insulin resistance, have been regarded as independent predictors major adverse cardiac events (MACEs) PCI. Whether combination rSS TyG improves predictive ability for MACEs in patients with type 2 diabetes mellitus (T2DM) undergoing PCI remains...
Abstract Background Triggering receptor expressed on myeloid cells 2 (TREM2), a surface predominantly cells, is major hub gene in pathology-induced immune signaling. However, its function hepatocellular carcinoma (HCC) remains controversial. This study aimed to evaluate the role of TREM2 tumor microenvironment context HCC progression. Methods was experimentally induced wild-type (WT) and Trem2 -deficient ( −/− ) mice, clinical sample analysis vitro studies macrophages were conducted. treated...
Cervical cancer is a leading malignancy in female reproductive system. While AI-assisted cytology offers cost-effective and non-invasive screening solution, current systems struggle with generalizability complex clinical scenarios. To address this issue, we introduced Smart-CCS, generalizable Cancer Screening paradigm based on pretraining adaptation to create robust systems. develop validate first curated large-scale, multi-center dataset named CCS-127K, which comprises total of 127,471...
Large-scale populations in the world have been vaccinated with COVID-19 vaccines, however, breakthrough infections of SARS-CoV-2 are still growing rapidly due to emergence immune-evasive variants, especially Omicron. It is urgent develop effective broad-spectrum vaccines better control pandemic these variants. Here, we present a mosaic-type trimeric form spike receptor-binding domain (mos-tri-RBD) as vaccine candidate, which carries key mutations from Omicron and other circulating Tests rats...
Thermostability is a fundamental property of proteins to maintain their biological functions. Predicting protein stability changes upon mutation important for our understanding structure-function relationship, and also great interest in engineering pharmaceutical design.
The Global Registry of Acute Coronary Events (GRACE) score is a powerful tool used to predict in-hospital mortality after acute myocardial infarction (AMI) and does not include glycometabolism-related index. We investigated whether the addition stress hyperglycemia ratio (SHR) provides incremental prognostic value in GRACE score.A retrospective cohort 613 AMI patients was enrolled present analyses. were stratified according primary endpoint (in-hospital mortality) tertiles SHR.During...
Background Due to seriously imbalanced distribution of follow-up clinics in China, routine in-office visits are erratically attended by many cardiovascular implantable electronic device (CIED) patients. Meanwhile, remote monitoring is significantly underutilized. Novel tools address the current predicament China urgently needed. Objectives To assess reliability and feasibility cloud CIED Methods A total 325 patients from 13 hospitals Sichuan Province, were enrolled. Information on patients’...
SARS-CoV-2 related coronaviruses (SARS-CoV-2r) from Guangdong and Guangxi pangolins have been implicated in the emergence of future pandemics. We previously reported culture a SARS-CoV-2r GX_P2V pangolins. Here we report isolate rapidly adapted to Vero cells by acquiring two genomic mutations: an alanine valine substitution nucleoprotein 104-nucleotide deletion hypervariable region (HVR) 3'-terminus untranslated (3'-UTR). further characterization variant (renamed GX_P2V(short_3UTR)) vitro...
In the aorta-gonad-mesonephros (AGM) region of mouse embryos, pre-hematopoietic stem cells (pre-HSCs) are generated from rare and specialized hemogenic endothelial (HECs) via endothelial-to-hematopoietic transition, followed by maturation into bona fide hematopoietic (HSCs). As HECs also generate a lot progenitors not fated to HSCs, powerful tools that pre-HSC/HSC-specific become urgently critical. Here, using gene knockin strategy, we firstly developed an Hlf-tdTomato reporter model...
Abstract Background Emerging evidence has highlighted the critical roles of long noncoding RNAs (lncRNAs) in tumor development and progression. However, biological functions underlying mechanisms DLEU1 esophageal squamous cell carcinoma (ESCC) remain unclear. Methods LncRNA expression ESCC tissues was explored using lncRNA microarray datasets. The functional were demonstrated by a series vitro vivo experiments. RNA pull-down immunoprecipitation assays performed to demonstrate potential...
The respiratory syncytial virus (RSV) fusion (F) glycoprotein is highly immunogenic in its prefusion (pre-F) conformation. However, the protein unstable, and conformation must be stabilized for it to function effectively as an immunogen vaccines. We present a mutagenesis strategy arrest RSV F pre-F state by blocking localized changes structure that accompany large-scale conformational rearrangements. generated series of mutants screened them vitro assess their potential forming stable pre-F....
Abstract An ongoing randomized, double-blind, controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate, named NVSI-06-09, as booster dose in subjects aged 18 years older from United Arab Emirates (UAE), who had administered two or three doses inactivated BBIBP-CorV at least 6 months prior enrollment. The participants were randomly assigned with 1:1 receive NVSI-06-09 BBIBP-CorV. primary outcomes against severe acute...