A5100581597- Pancreatic function and diabetes
- Gallbladder and Bile Duct Disorders
- Diabetes and associated disorders
- Xenotransplantation and immune response
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cannabis and Cannabinoid Research
- Transplantation: Methods and Outcomes
- Parasite Biology and Host Interactions
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Esophageal and GI Pathology
- Renin-Angiotensin System Studies
- Anesthesia and Neurotoxicity Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sirtuins and Resveratrol in Medicine
- Renal Transplantation Outcomes and Treatments
- Mollusks and Parasites Studies
- Advanced X-ray and CT Imaging
- Helminth infection and control
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- Olfactory and Sensory Function Studies
- Metabolomics and Mass Spectrometry Studies
National Vaccine and Serum Institute
2024
Shanghai Astronomical Observatory
2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Ministry of Agriculture and Rural Affairs
2024
Jilin Maternity and Child Health Care Hospital
2023
Shandong Provincial Hospital
2023
Shandong University
2023
Bengbu Medical College
2023
Hormone-sensitive lipase (HSL) is an intracellular that plays important role in the hydrolysis of triacylglycerol adipose tissue. HSL has been shown to interact with adipocyte lipid-binding protein (ALBP), a member family proteins bind fatty acids and other hydrophobic ligands. The current studies have addressed functional significance association mapped site interaction between ALBP. Incubation homogeneous ALBP purified, recombinant <i>in vitro</i> resulted 2-fold increase substrate...
Background Hypoxia-inducible factor-1α (HIF-1α) is overexpressed in many human tumors and their metastases, closely associated with a more aggressive tumor phenotype. The aim of the present study was to investigate effect resveratrol (RES) on expression ischemic-induced HIF-1α vascular endothelial growth factor (VEGF) rat liver. Methods Twenty-four rats were randomized into Sham, ischemia/reperfusion (I/R), RES preconditioning groups. I/R induced by portal pedicle clamping for 60 minutes...
Clear cell renal carcinoma (ccRCC) is the prominent histological subtype of (RCC) with high incidence local recurrence and distant metastasis. It has been documented that circular ribonucleic acids (circRNAs) play crucial roles in development cancers; however, study on exploring role circRNAs ccRCC still remains limited. In present study, we aimed to evaluate biological function a novel circRNA UBAP2 (circUBAP2) underlying mechanism. Our results showed circUBAP2 expression was significantly...
Eggs, with their high nutritional value, are great carriers for enriching nutrients. In this study, selenium- and/or zinc-enriched eggs (SZE) were obtained and effects on ameliorating oxidative stress injury, alleviating cognitive impairment, maintaining intestinal flora balance in a D-gal-induced aging mice model investigated. As determined by the Y-maze test, SZE restored learning memory abilities increased Ach level AChE activity of (p < 0.05). Meanwhile, supplementation low-dose...
Management of patients with spontaneous rupture hepatocellular carcinoma in a single centre is reported and the diagnosis treatment are discussed.The clinical presentations, 28 cases were reviewed.Twenty-six had sudden right upper-quadrant abdominal pain 53.5% hypovolaemic shock on admission. The median survival who received one-stage, two-stage tumour resection only transarterial embolization was 370, 483.5 60 days, respectively. prognosis underwent conservative or surgical haemostasis...
Background Xenotransplantation is a promising approach to circumventing the current organ shortage. However, T-cell-dependent anti-xenoresponses are major challenge successful xenografts. Given advantages of use CTLA4-Ig in survival allografts, purpose study was investigate therapeutic potential CTLA4-IgG4 modified immature dendritic cells (imDCs) prevention islets xenograft rejection. Methods constructed by fusion extracellular regions porcine CTLA4 human hIgG4 Fc region. The imDCs were...
The Educational Adaptive-optics Solar Telescope at the Shanghai Astronomy Museum has been running routine astronomical observations since 2021. It is a 65-cm-aperture Gregorian solar telescope for scientific education, outreach, and research. system designed in an "open" format so that tower architecture can be integrated with it, visitors watch live from inside tower. Equipped adaptive optics, high-resolution imaging system, integral field unit spectro-imaging this obtain images TiO H-α...
The respiratory syncytial virus (RSV) fusion (F) glycoprotein is highly immunogenic in its prefusion (pre-F) conformation. However, the protein unstable, and conformation must be stabilized for it to function effectively as an immunogen vaccines. We present a mutagenesis strategy arrest RSV F pre-F state by blocking localized changes structure that accompany large-scale conformational rearrangements. generated series of mutants screened them vitro assess their potential forming stable pre-F....
Porcine pancreatic islets fused with pCTLA4-Ig were transplanted into diabetic rats. Xenografts survival was observed, and the underlying immunological rejection mechanisms investigated.Control porcine islets, empty vector (Adv-GFP)-transfected, gene-modified renal capsule of The rates xenografts observed. Changes in serum levels IL-4 γ-IFN recipients assessed.The time group 34.50 ± 4.14 days, which longer than those control (34.50 days vs. 7.43 1.72 7.22 days; P < 0.01). between groups rats...
Although the global spread of emerging zoonosis, human angiostrongyliasis, has attracted increasing attention, understanding specific gene function been impeded by inaccessibility genetic manipulation pathogen nematode causing this disease, Angiostrongylus cantonensis. Many parasitic proteases play key roles in host-parasite interactions, but those A. cantonensis are always expressed as inactive form prokaryotic expression systems, thereby impeding functional studies. Hence, a lentiviral...
Bisphenol A (BPA), a xenoestrogen commonly used in plastics, may act as an endocrine disruptor, which indicates that BPA might be public health risk. The present study aimed to investigate the effect of on 17β‑estradiol (E2)‑mediated protection against liver ischemia/reperfusion (I/R) injury, and identify underlying mechanisms using rat model. total 56 male Sprague Dawley rats were randomly divided into following seven groups: i) Sham; ii) I/R; iii) Sham + BPA; iv) I/R v) E2; vi) E2 vii)...
Background We have observed at our clinical work that acute lung injury (ALI) often occurs in patients transplanted with donor livers persevered for long time. So, we conducted this study to investigate the influence of cold preservation time (CPT) liver on ALI induced by transplantation (LT), and further role nuclear factor-κB (NF-κB) process. Methods Wistar rats were used as donors recipients establish orthotopic rat models. Donor preserved 4°C different lengths The effect NF-κB inhibitor,...
Mounting research indicates that brain-derived neurotrophic factor (BDNF), has great potential to increase neuro-hyperresponsiveness and airway resistance in allergic disease. The expression level of BDNF been found be notably elevated lung/nasal lavage (NAL) fluid. However, the position ciliated cells with rhinitis remains unclear.Nasal mucosal were collected from patients (AR) mice which performed under different allergen challenge time, then observed located through immunofluorescence...
Housework is the major part of physical output in a family; energy consumption housewife 3000 kcal/day. The kitchen typical working area house, and degree comfort relies greatly on reasonable heights sink, work surface cooker. This study used 18 subjects for four tests (heart rate, subjective assessment, photographic technique method limits) simulating operations to investigate cooking table.