A5049425736- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Neonatal Respiratory Health Research
- Viral Infections and Outbreaks Research
National Vaccine and Serum Institute
2024
The respiratory syncytial virus (RSV) fusion (F) glycoprotein is highly immunogenic in its prefusion (pre-F) conformation. However, the protein unstable, and conformation must be stabilized for it to function effectively as an immunogen vaccines. We present a mutagenesis strategy arrest RSV F pre-F state by blocking localized changes structure that accompany large-scale conformational rearrangements. generated series of mutants screened them vitro assess their potential forming stable pre-F....
Abstract Respiratory syncytial virus (RSV) is one of the most important pathogens causing respiratory tract infection in humans, especially infants and elderly. The identification structural resolution potent neutralizing epitopes on RSV fusion (F) protein enable an “epitope-focused” vaccine design. However, display F epitope II surface widely-used human hepatitis B core antigen (HBcAg) has failed to induce antibody response mice. Here, we used hepadnavirus (HcAg) from different mammalian...