A5100407183- Circular RNAs in diseases
- MicroRNA in disease regulation
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Genomics and Phylogenetic Studies
- Enzyme Structure and Function
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Infective Endocarditis Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Cell death mechanisms and regulation
- Genetics, Aging, and Longevity in Model Organisms
- Cancer-related gene regulation
- Spaceflight effects on biology
- Natural product bioactivities and synthesis
- Sesquiterpenes and Asteraceae Studies
- DNA Repair Mechanisms
- NF-κB Signaling Pathways
- RNA modifications and cancer
- interferon and immune responses
- Phytochemical Studies and Bioactivities
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
Northwestern Polytechnical University
2025
Henan University of Traditional Chinese Medicine
2020-2024
Cleveland State University
2021-2023
Beijing Technology and Business University
2023
Beijing Center for Disease Prevention and Control
2022
Shandong University
2021
First Affiliated Hospital of Jiamusi University
2021
First Affiliated Hospital of Xi'an Jiaotong University
2017-2020
Affiliated Hospital of Guizhou Medical University
2020
Guizhou University
2020
Abstract Apigenin (APG) is an edible plant-derived flavonoid that shows modest antitumor activities in vitro and vivo . APG treatment results cell growth arrest apoptosis various types of tumors by modulating several signaling pathways. In the present study, we evaluated interactions between TRAIL non-small lung cancer (NSCLC) cells. We observed a synergistic effect on NSCLC A549 cells H1299 were resistant to alone. The presence sensitized TRAIL-induced upregulating levels death receptor 4...
Quercetin (Quer) is a typical antioxidant flavonoid from plants that involved in bone metabolism, as well the progression of inflammatory diseases. Elevated levels tumor necrosis factor‑α (TNF‑α), pro‑inflammatory cytokine, can affect osteogenesis. In present study, TNF‑α was used to establish an <em>in vitro</em> model periodontitis. The effects Quer on, its potential role osteogenic response human periodontal ligament stem cells (hPDLSCs) under TNF‑α‑induced conditions and underlying...
Clear cell renal carcinoma (ccRCC) is the prominent histological subtype of (RCC) with high incidence local recurrence and distant metastasis. It has been documented that circular ribonucleic acids (circRNAs) play crucial roles in development cancers; however, study on exploring role circRNAs ccRCC still remains limited. In present study, we aimed to evaluate biological function a novel circRNA UBAP2 (circUBAP2) underlying mechanism. Our results showed circUBAP2 expression was significantly...
Background and Aims: The expression of pancreatic-duodenal homeobox 1 ( PDX1 ) in gastric cancer is aberrantly reduced. aim this study was to elucidate the regulation DNA methylation histone acetylation at promoter for silencing cancer. Methods:PDX1 response demethylation detected human cell lines by reverse transcription–polymerase chain reaction (PCR) western blot. Four CpG islands within 5′-flanking region gene were analyzed with their transcription activities being dual luciferase assay....
ABSTRACT Fusobacterium nucleatum (Fn), as a conditional pathogen, can cause range of oral and gastrointestinal diseases. However, existing clinical detection methods require expensive equipment complex procedures, which are inconvenient for large-scale screening in epidemiological research. The purpose this study was to establish reliable, rapid, inexpensive method based on CRISPR/Cas12a technology the Fn. Specific recombinase polymerase amplification (RPA) primer sequences crRNA were...
Abstract Numerous studies demonstrate that circular RNAs (circRNAs) are critical regulators of the occurrence and progression tumors. However, research on involvement circRNAs in lung squamous cell carcinoma (LUSC) is limited. In our study, circTIMELESS (also named hsa_circ_0000408 Human circRNA Database) was upregulated both LUSC tissues cells, expression positively associated with TNM stage. Moreover, silencing markedly suppressed invasion vitro disrupted proliferation as well vivo....
Degeneration and destruction of articular cartilage are the key characteristics osteoarthritis (OA). In recent studies, use astilbin (AST), primary active ingredient Astilbe chinensis, has been shown to correlate with a reduction in inflammatory disease symptoms. The present study aimed investigate effects mechanisms AST on OA. A rat model OA was constructed vivo experiments were performed using AST, PBS, control groups. tissues each group assessed by hematoxylin eosin toluidine blue...
Androgen receptor (AR) contributes to the progression of glioblastoma (GBM), and antiandrogen agents have potential be used for treatment GBM. However, AR mutation commonly happens in GBM, which makes less effective. Heat shock 27 kDa protein (HSP27) is a well-documented chaperone stabilize ARs. Inhibition HSP27 results degradation regardless status ARs, good target abolish ARs Compound I inhibitor that significantly induces GBM cells via proteasomal pathway, it selectively inhibits...
Glioblastoma (GBM) is the most common malignant brain tumor with poor prognosis under current standard treatment. It critical to develop new approaches selectively battle disease. GBM sex differences suggest that an androgen receptor (AR) a potential therapeutic target treat AR-overexpressed GBM. Heat shock 27 kDa protein (HSP27) well-documented chaperone stabilizes AR. Inhibition of HSP27 leads AR degradation, indicating inhibitors could suppress activity in We have identified lead...
Phycocyanin has been reported to exert antineoplastic function in non-small cell lung cancer (NSCLC), while the underlying molecular mechanism is still largely unclear. In this study, a whole transcriptome resequencing was employed. Results showed that lncRNA LINC00852 inhibited by phycocyanin NSCLC cells. Knockdown expression resulted attenuated proliferation, viability and migration ability of Meanwhile, dual-luciferase reporter assay indicated acted as ceRNA miR-29a-3p which further...
Phycocyanin is a type of marine food additive with multiple biological properties, including anticancer activity, but its underlying antineoplastic mechanism in non-small cell lung cancer (NSCLC) remains unclear. To investigate the regulatory phycocyanin NSCLC, lncRNA microarray analysis was performed using phycocyanin-treated A549 model. The classification and expression lncRNAs were determined. profiles differentially expressed generated analyzed Kyoto Encyclopedia Genes Genomes (KEGG)...
To study the effects of different types commercially available drinks/beverages on neurobehavior using model organism C. elegans , and critically review their potential health hazards. Eighteen kinds beverages from supermarket were randomly selected grouped into seven categories namely functional beverage, tea plant protein fruit juice dairy carbonated beverage coffee beverage. The pH value, specific gravity osmotic pressure also examined. L4 stage N2 worms exposed to concentration tested...
断—砂配置输导体系作为油气运移的主要通道，控制着油气的分布。为厘清留楚地区东二段、东三段油气分布规律，基于三维地震资料及钻井资料，刻画断裂优势输导通道和连通砂体分布，通过东二段、东三段断—砂配置输导体系与下伏沙一段烃源岩之间关系，结合东二段、东三段油气分布，研究留楚地区东二段、东三段断—砂配置输导油气能力及其与油气聚集关系。研究结果表明：留楚地区东二段、东三段输导断裂两侧发育大量砂体，只有输导断裂与连通砂体配置合适，才可形成沙一段烃源岩向东二段、东三段储层运移的断—砂配置输导体系。留楚地区东二段、东三段强输导油气能力断—砂配置输导体系发育，主要分布在其北部地区；其次为弱输导油气能力断—砂配置输导体系，主要分布在其东南部地区；中等输导油气能力断—砂配置输导体系最不发育，仅分布在其中部及东、西边部地区。