Li Zhan

ORCID: 0000-0002-0832-0354
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About
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Research Areas
  • Advanced Fiber Laser Technologies
  • Photonic Crystal and Fiber Optics
  • Advanced Fiber Optic Sensors
  • Laser-Matter Interactions and Applications
  • Photonic and Optical Devices
  • Quantum optics and atomic interactions
  • Optical Network Technologies
  • Advanced Photonic Communication Systems
  • Mechanical and Optical Resonators
  • Photorefractive and Nonlinear Optics
  • Atomic and Subatomic Physics Research
  • Plasmonic and Surface Plasmon Research
  • Semiconductor Lasers and Optical Devices
  • Nonlinear Waves and Solitons
  • Immune Cell Function and Interaction
  • Geophysics and Sensor Technology
  • Medical Research and Treatments
  • Nonlinear Photonic Systems
  • Optical Coherence Tomography Applications
  • Rheumatoid Arthritis Research and Therapies
  • Traditional Chinese Medicine Analysis
  • Phytochemistry and Biological Activities
  • Metabolomics and Mass Spectrometry Studies
  • Protease and Inhibitor Mechanisms
  • Cardiac Fibrosis and Remodeling

Shanghai Jiao Tong University
2016-2025

Guangxi Normal University
2025

Daping Hospital
2020-2024

Army Medical University
2024

Women's Hospital, School of Medicine, Zhejiang University
2023

Institute of Microbiology
2021

Stevens Institute of Technology
2021

Shanghai Children's Hospital
2021

Shandong Provincial QianFoShan Hospital
2019-2020

Shandong University
2019-2020

We have proposed and demonstrated a multiwavelength fiber laser based on nonlinear polarization rotation (NPR). The mechanism for stable room-temperature operation contributes to the ability of intensity-dependent loss in NPR effectively alleviate mode competition. In addition, through tuning birefringence filter, lasing wavelength can be accurately tuned free spectrum range in-line periodic filter.

10.1364/ol.33.000324 article EN Optics Letters 2008-02-08

We study theoretically and experimentally the subharmonic entrainment (SHE) breather soliton in mode-locked lasers for first time, which ratio of period to round-trip time is an integer. build a non-Hermitian degeneracy map soliton, illustrate that SHE arises between two exceptional points (EPs). obtain at 20, observe evolution when tuning gain and/or cavity loss, prove this phenomenon can improve stability soliton. Our research brings insight into EP physics ultrafast makes laser powerful...

10.1103/physrevlett.125.163901 article EN Physical Review Letters 2020-10-12

Laser state active controlling is challenging under the influence of inherent loss and other nonlinear effects in ultrafast systems. Seeking an extension degree freedom optical devices based on low-dimensional materials may be a way forward. Herein, anisotropic quasi-one-dimensional layered material Ta

10.1038/s41377-024-01423-3 article EN cc-by Light Science & Applications 2024-04-07

We demonstrate the generation of 12-wavelength comb with 14.5-nm tunable range in Brillouin-Erbium fiber laser. This is achieved through tuning gain profile Erbium-doped by a Sagnac loop filter 18-cm polarization-maintaining fiber, conjunction modifying wavelength Brillouin pump. The experiment also demonstrates that closely equal to 3-dB bandwidth due its periodic transmission profile. Meanwhile, effect 980-nm pump on multiwavelength investigated. power has great number and output generated...

10.1109/lpt.2004.833097 article EN IEEE Photonics Technology Letters 2004-08-23

A multiwavelength erbium-doped fiber (EDF) laser based on a nonlinear amplifying loop mirror (NALM) is proposed and experimentally demonstrated. The NALM provides intensity-dependent transmissivity to equalize different-wavelength powers the transmission can be uniquely optimized by controlling cavity loss associated with section of un-pumped EDF, which also enhances output signal-to-noise ratio (SNR). Through adjusting polarization controllers (PCs), under only 70 mW pump power, up...

10.1364/oe.20.007088 article EN cc-by Optics Express 2012-03-13

Objectives To clarify the key role of circulating interferon-γ (IFN-γ) and to improve clinical efficacy mesenchymal stem cell (MSC) transplantation (MSCT) in patients with rheumatoid arthritis (RA). Methods Study wild-type or IFN-γR -/- MSCT was first evaluated a murine model collagen-induced (CIA) following which phase 1/2 randomised controlled study conducted 63 RA who responded poorly regular treatments. Subjects were randomly assigned an monotherapy group (n=32) plus recombinant human...

10.1136/annrheumdis-2020-217798 article EN Annals of the Rheumatic Diseases 2020-06-19

We proposed and demonstrated a new concept of switchable multiwavelength erbium-doped fiber ring laser with multisection high-birefringence loop mirror (HiBi-FLM). The HiBi-FLM results in the operating on different allowed wavelengths. wavelength switching can be achieved by modifying reflection spectrum through two polarization controllers. experiment demonstrates lasing operation within random combination three wavelengths, as well large (/spl sim/40 dB) output signal to background noise ratio.

10.1109/lpt.2005.849999 article EN IEEE Photonics Technology Letters 2005-06-22

Passive harmonically mode-locked fiber ring laser with scalable repetition rate up to 1.2 GHz has been experimentally demonstrated. Two types of stabilization mechanisms for passive harmonic mode-locking are identified at different rates. Through investigating the dynamics pulse generation, it is found that a new operation mode, multipulse bunching, favors higher order harmonic. The supermode suppression rates trains 439 MHz and 1.145 40 dB 30 dB, respectively.

10.1002/lapl.200710017 article EN Laser Physics Letters 2007-02-27

We have demonstrated a novel multiwavelength Brillouin-erbium fiber laser (BEFL), in which the Brillouin pump is self-excited within linear cavity, instead of injection from external cavity or direct generation intracavity. By using this simple scheme, more than 160 Stokes lines has been experimentally demonstrated, largest one achieved BEFLs to best our knowledge. Also, single longitudinal mode operation and low noise performance output wavelength line confirmed. Meanwhile, experiment...

10.1364/oe.14.010233 article EN cc-by Optics Express 2006-01-01

We demonstrate the direct generation of 55 fs pulses from an all-fiber Erbium-doped ring laser oscillator using nonlinear polarization rotation mode-locking. The average output power is 56.4 mW but limited by available pump 330 mW. linear chirped pulse duration after recompression standard single-mode fiber. show to resist optical wave breaking with a smooth spectrum without any side lobe and cw-breakthrough. This exhibits relatively high transfer efficiency 17% single energy reaches 1.5 nJ.

10.1364/oe.17.004284 article EN cc-by Optics Express 2009-03-03

A novel concept of individually switchable and widely tunable erbium-doped multiwavelength fiber laser (MWFL) is proposed experimentally demonstrated. The key component the a channel transmissivity variable comb filter composed two cascaded different-length long-period gratings (LPFGs), named mismatching LPFGs. When inserted into cavity, this polarization-dependent functions as wavelength selector switching simultaneously. By properly adjusting polarization controllers (PCs) in cavity high...

10.1109/jlt.2011.2168386 article EN Journal of Lightwave Technology 2011-09-22

We report superluminal propagation in optical fibers using Brillouin lasing oscillation a ring cavity. Negative group velocity through 10-m single mode fiber has been experimentally demonstrated. An advancement of 221.2 ns was observed before the input signal, which achieved with very high slope efficiency $211.3\text{ }\text{ }\mathrm{ns}/\mathrm{dB}$. This indicates that this way is suitable for long-distance low-loss via fibers. Correspondingly, $\ensuremath{-}0.151c$ and index...

10.1103/physrevlett.107.093903 article EN Physical Review Letters 2011-08-24

A watt-level ultrahigh optical signal-to-noise ratio (OSNR) single-longitudinal-mode (SLM) tunable Brillouin fiber laser (BFL) has been demonstrated.By optimizing the length of single mode (SMF) cavity at 11m and its output sixty percent, 1.04 W power, as well stable SLM operation is obtained 2.24 pump power. The pass BFL advantage that frequency doesn't need to match mode, thus stability greatly improved. As only SMF used in cavity, operate wavelength can be without restriction from self...

10.1364/ol.38.000019 article EN Optics Letters 2012-12-19

Background— β-Adrenergic receptors (βARs) play paradoxical roles in the heart. On one hand, βARs augment cardiac performance to fulfill physiological demands, but on other prolonged activations of exert deleterious effects that result heart failure. The signal transducer and activator transcription 3 (STAT3) plays a dynamic role integrating multiple cytokine signaling pathways number tissues. Altered activation STAT3 has been observed failing hearts both human patients animal models. Our...

10.1161/circulationaha.115.017472 article EN Circulation 2015-12-02

Though normal-dispersion mode-locked fiber lasers generally work on a single-pulse regime due to the large chirp of pulses, we observe bound states one kind dissipative solitons in laser. The separation between bounded pulses such soliton molecules increases with pump power, and also varies settings polarization controllers, which is consistent other kinds as solitons. Our study indicates that state an intrinsic feature independent pulse profiles, stimulated by overdriving mode-locking mechanisms.

10.1109/lpt.2013.2257720 article EN IEEE Photonics Technology Letters 2013-04-12

We systematically investigate the passive harmonic mode locking (HML) of bound states two solitons in a fiber laser that has been locked by nonlinear polarization rotation (NPR). The experiment shows stable HML state (BSs) with fixed and discrete separation is obtained. repetition rate changes increasing pump power slightly altering cavity. dynamic similar to single-pulse operation. In our experiment, can be turned from fundamental up ninth-order when increased 168 476.1 mW. Once BSs are...

10.1364/ol.40.001065 article EN Optics Letters 2015-03-10

COVID-19 is a severe disease in humans, as highlighted by the current global pandemic. Several studies about metabolome of patients have revealed metabolic disorders and some potential diagnostic markers during progression. However, longitudinal changes metabolomics patients, especially their association with progression, are still unclear. Here, we systematically analyzed dynamic serum demonstrating that most metabolites did not recover 1-3 days before discharge. A prominent signature...

10.3389/fmicb.2021.723818 article EN cc-by Frontiers in Microbiology 2021-12-03

The immunosuppressive capacity of mesenchymal stem cells (MSCs) is dependent on the "license" several pro-inflammatory factors to express molecular profiles, which determines therapeutic efficacy MSCs in immune-mediated inflammatory diseases. Of those, interferon-γ (IFN-γ) a key inducer for expression profiles; however, mechanism underlying this effect unknown. To elucidate regulation and biological functions N6-methyladenosine (m6A) modification by IFN-γ-licensing MSCs. Epitranscriptomic...

10.1016/j.jare.2024.06.019 article EN cc-by-nc-nd Journal of Advanced Research 2024-06-01

We demonstrate crossbar all-optical switching (AOS) on an add-drop microring resonator chip made of periodically poled lithium niobate. Utilizing quantum Zeno blockade (QZB) induced by sum-frequency generation, a signal is switched between the resonator’s two output ports pump wave. The contrast 3.35 and 8.27 dB, respectively, at through drop during quasi-continuous operation 5.15 9.01 dB pulsed operation. These results purely parametric approach to optical routing computing for information...

10.1364/ol.550028 article EN Optics Letters 2025-01-31

We propose and demonstrate a self-seeded multiwavelength Brillouin-erbium fiber laser with an internally self-excited Brillouin pump, which is achieved by incorporation of length single-mode together Sagnac loop mirror into ring cavity. In this simple scheme the pump in cavity then used to seed comb fiber. Stable generation more than 120 Stokes wavelengths relatively uniform amplitudes demonstrated scheme. It also shown that such has good stability repeatability.

10.1364/ol.30.000486 article EN Optics Letters 2005-03-01

We proposed and experimentally demonstrated an extremely simple feasible slow-light technique to achieve tunable optical delay by using the Er/Yb codoped fiber Bragg grating (FBG). The signal light experiences strong dispersion when it is launched into reflection edge of FBG, group value determined wavelength pump power. In experiment, a controllable 0.9 ns can be obtained through changing 980 nm velocity slowed down 5.6x10(7) m/s, which 19% speed in free space. It provides very approach...

10.1364/oe.17.022217 article EN cc-by Optics Express 2009-11-19
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