A5057044818- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Viral-associated cancers and disorders
- Radiopharmaceutical Chemistry and Applications
- Hemostasis and retained surgical items
- Cancer Immunotherapy and Biomarkers
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- RNA Interference and Gene Delivery
- Platelet Disorders and Treatments
- HIV-related health complications and treatments
- Advanced Drug Delivery Systems
- Dendrimers and Hyperbranched Polymers
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
Northwest University
2023-2025
Army Medical University
2019-2024
Daping Hospital
2024
First People's Hospital of Chongqing
2023
Army Medical College
2020
Chongqing University
2020
Carrier-free nanomedicines mainly composed of drug nanocrystals are considered as promising candidates for next-generation nanodrug formulations. However, such still need to be stabilized by additive surfactants, synthetic polymers, or biologically based macromolecules. Based on the strong intermolecular interactions between indomethacin (IDM, a COX-2 inhibitor) and paclitaxel (PTX, chemotherapy drug), we herein successfully engineered novel kind carrier-free that organized IDM-induced PTX...
The immunosuppressive capacity of mesenchymal stem cells (MSCs) is dependent on the "license" several pro-inflammatory factors to express molecular profiles, which determines therapeutic efficacy MSCs in immune-mediated inflammatory diseases. Of those, interferon-γ (IFN-γ) a key inducer for expression profiles; however, mechanism underlying this effect unknown. To elucidate regulation and biological functions N6-methyladenosine (m6A) modification by IFN-γ-licensing MSCs. Epitranscriptomic...
Abstract Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen combinations self‐assembling nanomedicines, employing physiochemical parameters predict formation via machine learning. Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) are identified antineoplastic drugs, with high loading. Nanomedicines, PEG‐coated indomethacin/paclitaxel...
Yeast microcapsule based biomimetic delivery of bindarit at a low dose exerts good oral targeted therapeutic effect on atherosclerosis.
Abstract Background Monocyte/macrophage-targeting delivery systems (MTDSs) have been focused upon as an emerging routine for delivering drugs to treat various macrophage-related diseases. However, the ability of MTDSs distinguish different diseases and their impact on macrophage function disease progression not systematically revealed, which is important actively targeted therapeutic or diagnostic strategies. Results Herein, we used dextran-modified polystyrene nanoparticles (DEX-PS)...
To determine the role of N
Abstract Monocyte/macrophage targeting drug delivery system (MTDS) has been highly focused as an emerging routine for delivering drugs to various macrophage related diseases. However, the distinguishing ability towards different diseases of these systems and impact them on function disease progression have not systematically revealed, which is significantly important active therapeutic or diagnostic strategies. Herein, taking dextran modified polystyrene nanoparticles (DEX-PS) example, we...
Abstract Background: Monocyte/macrophage-targeting delivery systems (MTDSs) have been focused upon as an emerging routine for delivering drugs to treat various macrophage-related diseases. However, the ability of MTDSs distinguish different diseases and their impact on macrophage function disease progression not systematically revealed, which is important actively targeted therapeutic or diagnostic strategies. Results: Herein, we used dextran-modified polystyrene nanoparticles (DEX-PS)...