A5068680718- Ferroelectric and Piezoelectric Materials
- Microwave Dielectric Ceramics Synthesis
- Advanced ceramic materials synthesis
- HVDC Systems and Fault Protection
- High voltage insulation and dielectric phenomena
- Neurological Disease Mechanisms and Treatments
- High-Voltage Power Transmission Systems
- Microgrid Control and Optimization
- Magnesium Alloys: Properties and Applications
- Nanoparticle-Based Drug Delivery
- Lightning and Electromagnetic Phenomena
- Nanoplatforms for cancer theranostics
- Power Transformer Diagnostics and Insulation
- Bone Tissue Engineering Materials
- Intracerebral and Subarachnoid Hemorrhage Research
- Power Systems Fault Detection
- Supramolecular Self-Assembly in Materials
- Smart Grid and Power Systems
- Photochromic and Fluorescence Chemistry
- Topic Modeling
- Optimal Power Flow Distribution
- MXene and MAX Phase Materials
- Drug Solubulity and Delivery Systems
- Hemostasis and retained surgical items
- Barrier Structure and Function Studies
Chongqing University of Technology
2020-2025
Army Medical University
2024
Shandong University
2011-2023
Shanghai Jiao Tong University
2021-2022
Shenzhen Polytechnic
2022
University of Science and Technology of China
2008-2022
Anhui Institute of Optics and Fine Mechanics
2022
Laser Research Institute
2022
State Key Laboratory of Metal Matrix Composites
2022
Tianjin University
2017-2019
Abstract: This study aimed to optimize and evaluate a thermoresponsive ophthalmic in situ gel containing curcumin-loaded albumin nanoparticles (Cur-BSA-NPs-Gel). Albumin were prepared via desolvation method, the gels cold method. The central composite design response surface method was used effects of varying Pluronic ® F127 F68 concentrations on sol–gel transition temperature, which is an indicator optimum formulations. optimized formulation free-flowing liquid below 30.9°C that transformed...
Cancer metastasis is the main cause of cancer-related deaths and involves interaction between tumor cells neutrophils. In this study, we developed activated neutrophil membrane-coated nanoparticles (aNEM NPs) as nanodecoys to block neutrophil-mediated cancer metastasis. The aNEM NPs were fabricated by cloaking poly(lactic acid) with membranes derived from neutrophils inherited functional proteins We demonstrated that could interfere recruitment primary premetastatic niches, inhibit adhesion...
Necrotic cell death is a hallmark feature of ischemic stroke and it may facilitate inflammation by releasing intracellular components after cell-membrane rupture. Previous studies reported that β-caryophyllene (BCP) mitigates cerebral ischemia-reperfusion (I/R) injury, but the underlying mechanism remains unclear. We explored whether BCP exerts neuroprotective effect in I/R injury through inhibiting necroptotic inflammation. Primary neurons with without (0.2, 1, 5, 25 μM) treatment were...
Online monitoring of the mechanical performance onload tap changers (OLTCs) within high-voltage (HV) power transformers is utmost significance for a safe, stable, and reliable operation systems. This paper investigated novel strategy based on Hidden Markov Model (HMM) fault diagnosis OLTCs. With partition, normalization, vector quantization spectral density obtained vibration signals, feature extraction methodology was presented discrete spectrums which, to farthest extent, could retain...
β-Caryophyllene (BCP) mediates neuroprotection in cerebral ischemic animals. The neurovascular unit (NVU) acts as an intricate network to maintain the neuronal homeostatic microenvironment. However, effects exerted by BCP on NVU remain unclear. Therefore, we established vitro model investigate of oxygen-glucose deprivation and re-oxygenation (OGD/R)-induced injury. This involved co-culture brain microvascular endothelial cells, neurons, astrocytes. (10 μmol/L) was applied for 24 h prior...
Abstract Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen combinations self‐assembling nanomedicines, employing physiochemical parameters predict formation via machine learning. Non‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) are identified antineoplastic drugs, with high loading. Nanomedicines, PEG‐coated indomethacin/paclitaxel...
As AI capabilities increasingly surpass human proficiency in complex tasks, current alignment techniques including SFT and RLHF face fundamental challenges ensuring reliable oversight. These methods rely on direct assessment become untenable when outputs exceed cognitive thresholds. In response to this challenge, we explore two hypotheses: (1) critique of can be easier than itself, extending the widely-accepted observation that verification is generation domain, as itself a specialized form...
Acute organ injuries represent a major public health concern, driven by inflammation and mitochondrial dysfunction, leading to cell damage failure. In this study, we engineered neutrophil membrane–fused mitochondria (nMITO), which combine the injury-targeting anti-inflammatory properties of membrane proteins with repairing function mitochondria. nMITO effectively blocked inflammatory cascades restored function, targeting both key mechanisms in acute injuries. addition, selectively targeted...
This work was conducted to prepare β-caryophyllene-hydroxypropyl-β-cyclodextrin inclusion complex (HPβCD/BCP) and investigate its effects mechanisms on cognitive deficits in vascular dementia (VD) rats. First, HPβCD/BCP prepared, optimized, characterized evaluated. AM630 were then administered VD rats upregulate downregulate the cannabinoid receptor type 2 (CB2). Results showed that can significantly increase bioavailability of BCP. Through Morris water maze test, attenuate learning memory...
We previously demonstrated in rats that noninvasive delayed limb ischemic preconditioning (LIPC) induced by three cycles of 5-min occlusion and reperfusion the left hind per day for days confers same cardioprotective effect as local heart, but mechanism has not been studied depth. The aim this project was to test hypothesis LIPC enhances myocardial antioxidative ability during ischemia-reperfusion a mitochondrial KATP channel (mito KATP)-dependent mechanism. Rats were randomized five groups:...
Light-driven fluorescence and emission enhancement of AOB-t8 in organic solution under UV light illumination was obtained, even though itself is negligibly fluorescent the initial nonirradiated solution.
Biodegradable magnesium (Mg) implants spontaneously releasing therapeutic agents against tumors are an intriguing approach for both tissue repair and tumor treatment. Anastomotic staples extensively used wound closure after surgical resection in patients with colorectal tumors. However, the safety of Mg anastomosis intestinal effect suppression remain elusive. Here, we a high-purity staple to study these issues. Based on results, found that it has potential heal wounds produced while...