A5063191774- Neurological Disease Mechanisms and Treatments
- Natural Compounds in Disease Treatment
- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinoids in leukemia and cellular processes
- Saffron Plant Research Studies
- Autophagy in Disease and Therapy
- Intracerebral and Subarachnoid Hemorrhage Research
- Cell death mechanisms and regulation
Institute of Physics
2025
University of Chinese Academy of Sciences
2025
Chongqing Medical University
2016-2019
Necrotic cell death is a hallmark feature of ischemic stroke and it may facilitate inflammation by releasing intracellular components after cell-membrane rupture. Previous studies reported that β-caryophyllene (BCP) mitigates cerebral ischemia-reperfusion (I/R) injury, but the underlying mechanism remains unclear. We explored whether BCP exerts neuroprotective effect in I/R injury through inhibiting necroptotic inflammation. Primary neurons with without (0.2, 1, 5, 25 μM) treatment were...
β-Caryophyllene (BCP) mediates neuroprotection in cerebral ischemic animals. The neurovascular unit (NVU) acts as an intricate network to maintain the neuronal homeostatic microenvironment. However, effects exerted by BCP on NVU remain unclear. Therefore, we established vitro model investigate of oxygen-glucose deprivation and re-oxygenation (OGD/R)-induced injury. This involved co-culture brain microvascular endothelial cells, neurons, astrocytes. (10 μmol/L) was applied for 24 h prior...
Interfacing complex oxides in atomically engineered layered structures can give rise to a wealth of exceptional electronic and magnetic properties that surpass those the individual building blocks. Herein, we demonstrate ferromagnetic spin order with high Curie temperature 608 K superlattices consisting otherwise paramagnetic perovskite LaNiO3 (LNO) antiferromagnetic LaFeO3 (LFO). The ferromagnetism likely results from covalent exchange due interfacial charge transfer Fe Ni cations. By...