A5016058133- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Anesthesia and Pain Management
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Eicosanoids and Hypertension Pharmacology
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Neuroscience and Neuropharmacology Research
- Advanced Chemical Sensor Technologies
- Pain Mechanisms and Treatments
- Electron Spin Resonance Studies
- Nitric Oxide and Endothelin Effects
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Sensors
- Receptor Mechanisms and Signaling
- Electrochemical sensors and biosensors
- Cardiac Arrest and Resuscitation
- Adrenal Hormones and Disorders
- Nausea and vomiting management
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- Veterinary Pharmacology and Anesthesia
- Lipid metabolism and disorders
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Beijing University of Chinese Medicine
2024
Northwest A&F University
2021-2023
Southwest University
2023
Sichuan Normal University
2017-2020
Tianjin Medical University
2009-2019
Changsha Central Hospital
2019
PLA Navy General Hospital
2011-2017
Phlorizin (PHZ) is one of phytonutrients in apples that contributes to the health-promoting effect implicated by saying, 'an apple a day keeps doctor away'. PHZ was firstly identified as competitive inhibitor sodium-glucose co-transporters-2 (SGLT2); however, its low bioavailability makes it hard fully explain pharmacological mechanisms. This study aimed investigate ameliorating on high-fat diet (HFD)-induced obesity via modulating "gut microbiota-barrier axis". Firstly, C57BL/6 J mice were...
Nanozymes have become a frontier of research recently and possess broad application prospects in the field analytical sensing. Herein, Fe–Mn bimetallic nanozyme (FeMnzyme) was proposed for colorimetric analysis ascorbic acid (AA). The FeMnzyme, with high specific surface area, consisted mixed oxide amorphous core α-FeOOH nanorod shell characterized by scanning electron microscope (SEM) Powder X-ray diffraction (XRD). It exhibits typical oxidase-like properties to catalyze oxidation colorless...
Nanoantibacterial agents based on catalytic activity were limited due to the low levels of endogenous H2O2 in microenvironment bacterial biofilms. However, additional will trigger more side effects healthy surroundings, which is still a great challenge. Herein, we report an acid-induced self-catalyzing platform dextran-coated copper peroxide nanoaggregates (DCPNAs) for antibiofilm and local infection therapy applications. The dextran-functionalized DCPNAs mediated conveniently purified via...
Although surgical resection provides a straightforward and effective treatment for most malignant solid tumors, tumor recurrence acute postoperative pain continue to be two big problems associated with this treatment. To resolve these problems, nanocrystal composite slow-releasing ropivacaine doxorubicin was fabricated in study. Briefly, self-assembling peptide used form nanoparticle complexes the drugs, based on which homogeneous nanocrystals were obtained by adjusting pH. In cultured human...
BACKGROUND: ET-26 hydrochloride (ET-26HCl) is a novel etomidate analogue designed to alleviate the adrenocortical suppression caused by while retaining rapid sedative-hypnotic onset and stable hemodynamic features of etomidate. This study compared anesthetic effect, stability, recovery profiles ET-26HCl, etomidate, drug propofol in rats. METHODS: The metabolic half-life ET-26HCl was determined vitro using high performance liquid chromatography analysis samples rat plasma liver homogenates...
Phlorizin (PHZ), a type of dihydrochalcone widely found in Rosaceae such as apples, is the first compound discovered sodium-glucose cotransporter (SGLT) inhibitor. It has been confirmed to improve symptoms diabetes and diabetic complications effectively. Like other flavonoids, bioavailability challenge PHZ wide phase I II metabolism digestive tract. In this study, we investigated pharmacokinetics contribution after oral intravenous administrations rats having 2 (T2D) normal rats. The...
A zero-dimensional bimetallic MOF-based nanozyme Co–Fe NDs with good antibacterial activity and biocompatibility was prepared by reducing the dimensionality. Meanwhile, K m of almost triple that precursor NSs.
While propofol can be detected in exhaled breath rats, robust evidence supporting its correlation with plasma concentrations or use predicting levels remains lacking. In this study, eighteen mechanically ventilated rats were divided into three groups and injected low (Group BL, n = 6), medium BM, high BH, 6) doses of propofol. The concentration (Ce-pro) was determined online using vacuum ultraviolet time-of-flight mass spectrometry (VUV-TOF MS), while the (Cp-pro) measured high-performance...
Fospropofol, a water-soluble prodrug of propofol, is metabolized into propofol by alkaline phosphatase after administration. This study aimed to develop pharmacokinetic-pharmacodynamic (PK-PD) model that correlates the concentration in exhaled air (Ce-pro-f) with its anesthetic effects, as measured bispectral index (BIS) beagles. Beagles receiving single intravenous infusion fospropofol at varying doses were divided three groups (n = 6): DBL-fospro group (15 mg/kg), DBM-fospro (30 and...
Propofol, a fast-acting anesthetic, requires precise titration to minimize adverse effects. While plasma-based monitoring is slow, exhaled propofol offers real-time, non-invasive alternative, though its clinical application remains limited. This...
Rationale: Slow-releasing formulation of local anesthetics (LAs) has been a promising strategy for pursuing long-acting opioid-free analgesia. Although many formulations based on carrier materials have successfully developed, challenges still remain in addressing not only the biocompatibility and biodegradability issues materials, but also potential inflammation caused by LAs. Methods: In this study, we developed slow-releasing ropivacaine methylprednisolone sodium succinate (MP),...
Background Diabetic kidney disease (DKD) is one of the common microvascular complications diabetes. The exploration serum biomarkers holds promise for improving efficiency and accuracy early DKD diagnosis. This study aims to investigate diagnostic value transforming growth factor-β1 (TGF-β1) cystatin C (CysC) in patients. Methods A total 126 patients with type 2 diabetes mellitus (T2DM) diagnosed at Dongzhimen Hospital, Beijing University Chinese Medicine, between May 2021 March 2023 were...
The α-klotho is crucial in diabetes and its related complications. This study seeks to explore the link between levels risk of diabetic kidney disease (DKD) as well all-cause cardiovascular mortality among individuals with type 2 mellitus (T2DM). investigation involved 126 Chinese T2DM patients 4,451 from National Health Nutrition Examination Survey (NHANES) database. To evaluate relationship DKD risk, multivariate logistic regression was utilized. Additionally, restricted cubic spline (RCS)...
To determine if dioscin protects cardiac cells from ischemia/reperfusion (I/R) injury by preventing apoptosis.Cardiac H9c2 were subjected to simulated I/R. Cell viability was evaluated the methyl thiazolyl tetrazolium (MTT) colorimetry assay. Reactive oxygen species (ROS) detected with dichlorodihydrofluorescein (DCF). Apoptosis flow cytometric Rhodamine 123 (Rho123) used measure mitochondrial membrane potential (ΔΨm). ELISA detect cytochrome c (Cyt-c) release mitochondria cytosol. Bax and...
Abstract The correlation between propofol concentration in exhaled breath ( C E ) and plasma P has been well-established, but its applicability for estimating the brain tissues B remains unknown. Given impracticality of directly sampling human tissues, rats are commonly used as a pharmacokinetic model due to their similar drug-metabolizing processes humans. In this study, we measured , mechanically ventilated injected with propofol. Exhaled samples from were collected every 20 s analyzed...
We previously demonstrated in rats that noninvasive delayed limb ischemic preconditioning (LIPC) induced by three cycles of 5-min occlusion and reperfusion the left hind per day for days confers same cardioprotective effect as local heart, but mechanism has not been studied depth. The aim this project was to test hypothesis LIPC enhances myocardial antioxidative ability during ischemia-reperfusion a mitochondrial KATP channel (mito KATP)-dependent mechanism. Rats were randomized five groups:...