A5073856482- Mass Spectrometry Techniques and Applications
- Advanced Chemical Sensor Technologies
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Ion-surface interactions and analysis
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Sensors
- Plasma Applications and Diagnostics
- Anesthesia and Sedative Agents
- Plasma Diagnostics and Applications
- RNA modifications and cancer
- Laser-induced spectroscopy and plasma
- RNA Research and Splicing
- Electrohydrodynamics and Fluid Dynamics
- Microfluidic and Capillary Electrophoresis Applications
- Gas Sensing Nanomaterials and Sensors
- Biosensors and Analytical Detection
- Mercury impact and mitigation studies
- Inhalation and Respiratory Drug Delivery
- Covalent Organic Framework Applications
- Pesticide Residue Analysis and Safety
- Recycling and utilization of industrial and municipal waste in materials production
- Optimal Power Flow Distribution
- Artificial Intelligence in Law
- Advanced biosensing and bioanalysis techniques
Sichuan University
2015-2025
Shanghai Electric (China)
2024
Xuzhou Medical College
2021-2024
Shanghai University of Electric Power
2024
Shandong University of Technology
2023
Chengdu University
2014-2021
Chengdu Medical College
2019
Xiangtan University
2012
Mixed exhaled air has been widely used to determine propofol concentrations with online analyzers, but changes in dead space proportions may lead inaccurate assessments of critical drug concentration data. This study proposes a method correct mixed by estimating pulmonary through reconstructing volumetric capnography (Vcap) from time-CO2 and time-volume curves, validated vacuum ultraviolet time-of-flight mass spectrometry (VUV-TOF MS). Existing monitoring parameters, including were Vcap. The...
A new ionization source based on microwave induced plasma was developed for ambient desorption/ionization. The microwave-induced desorption/ionization (MIPDI) composed of a copper Surfatron cavity where fused-silica tube centered axially. Stable nonlocal thermodynamic equilibrium generated in the quartz discharge when at frequency 2450 MHz coupled to cavity. Analytes deposited surface poly(tetrafluoroethylene) (PTFE) or slide after hydrofluoric acid (HF) etching were desorbed and ionized by...
A simple, label-free and cost-effective localized surface plasmon resonance (LSPR) immunosensing method was developed for detection of alpha-fetoprotein (AFP).
The development of an atmospheric pressure interface (API) with a high ion transfer efficiency and wide mass range is advantageous for the performance improvement spectrometry (MS) instruments. In this work, novel guide, namely, double-helix electrode funnel (DHE-IF), has been developed to enhance transmission over in rough vacuum region. DHE-IF consists two funnel-shaped helix electrodes. There are almost no potential "traps" along central axis due continuous structure compared stacked ring...
While propofol can be detected in exhaled breath rats, robust evidence supporting its correlation with plasma concentrations or use predicting levels remains lacking. In this study, eighteen mechanically ventilated rats were divided into three groups and injected low (Group BL, n = 6), medium BM, high BH, 6) doses of propofol. The concentration (Ce-pro) was determined online using vacuum ultraviolet time-of-flight mass spectrometry (VUV-TOF MS), while the (Cp-pro) measured high-performance...
Fospropofol, a water-soluble prodrug of propofol, is metabolized into propofol by alkaline phosphatase after administration. This study aimed to develop pharmacokinetic-pharmacodynamic (PK-PD) model that correlates the concentration in exhaled air (Ce-pro-f) with its anesthetic effects, as measured bispectral index (BIS) beagles. Beagles receiving single intravenous infusion fospropofol at varying doses were divided three groups (n = 6): DBL-fospro group (15 mg/kg), DBM-fospro (30 and...
Propofol, a fast-acting anesthetic, requires precise titration to minimize adverse effects. While plasma-based monitoring is slow, exhaled propofol offers real-time, non-invasive alternative, though its clinical application remains limited. This...
Additional multipole fields are unavoidable in real quadrupole linear ion traps (QLITs) and play a crucial role influencing their performance. In this study, the impact of these on ejection dynamics QLITs is exhaustively analyzed using vectorized Runge-Kutta method comprehensive theoretical model vibration involving all common fields. The comparison nonlinear resonance under different added reveals obvious from hexapole octopole resonances as well multiple points most Ion with dipole...
Ultrasensitive detection of metallic elements in liquids has attracted considerable attention fields such as environmental pollution monitoring and drinking water quality control. Hence, it is great significance to develop a sensitive simultaneous strategy for multiple metal liquid. Laser-induced breakdown spectroscopy (LIBS) technology shows unique advantages because its simple, rapid, real-time situ detection, but the laser energy will be greatly attenuated liquids; thus, sensitivity LIBS...
A novel ambient ionization technique for mass spectrometry, microfabricated glow discharge plasma (MFGDP), is reported. This device made of a millimeter-sized ceramic cavity with two platinum electrodes positioned face-to-face. He or Ar can be generated by direct current voltage several hundreds volts requiring total power below 4 W. The thermal plume temperature the was measured and found to between 25 80 °C at normal current. Gaseous, liquid, creamy, solid samples molecular weights up 1.5...
Eight breath biomarkers of T2DM were discovered by a new SPME-GC-MS based metabolic profiling tool.
Abstract Glioma is the most common primary malignant brain tumor in adults and remains an incurable disease at present. Thus, there urgent need for progress finding novel molecular mechanisms that control progression of glioma which could be used as therapeutic targets patients. The RNA binding protein cytoplasmic polyadenylate element-binding 2 (CPEB2) involved pathogenesis several tumors. However, role CPEB2 unknown. In this study, functional characterization mechanism were examined using...
Abstract The correlation between propofol concentration in exhaled breath ( C E ) and plasma P has been well-established, but its applicability for estimating the brain tissues B remains unknown. Given impracticality of directly sampling human tissues, rats are commonly used as a pharmacokinetic model due to their similar drug-metabolizing processes humans. In this study, we measured , mechanically ventilated injected with propofol. Exhaled samples from were collected every 20 s analyzed...
This study developed a large volume cold atmospheric plasma brush array, which was enhanced by dielectric barrier discharge integrating pair of DC glow in parallel. A platinum sheet electrode placed the middle chamber, effectively reduced breakdown voltage and working voltage. Emission spectroscopy diagnosis indicated that many excited argon atoms were distributed almost symmetrically lateral direction plasma. The concentration variations reactive species relative to gas flow rate current...
Abstract Exhaled breath and gastric-endoluminal gas (volatile products of diseased tissues) contain a large number volatile organic compounds, which are valuable for early diagnosis upper gastrointestinal (UGI) cancer. In this study, exhaled patients with UGI cancer benign disease were analyzed by chromatography-mass spectrometry (GC-MS) ultraviolet photoionization time-of-flight mass (UVP-TOFMS) to construct diagnostic models. Breath samples 116 77 subjects 114 76 collected. Machine...