A5101665547- Spinal Cord Injury Research
- Stroke Rehabilitation and Recovery
- Nerve Injury and Rehabilitation
- Cerebral Palsy and Movement Disorders
- Nerve injury and regeneration
- Gastrointestinal motility and disorders
- Spinal Dysraphism and Malformations
- Trauma Management and Diagnosis
- Gut microbiota and health
- Dysphagia Assessment and Management
- Trauma and Emergency Care Studies
- Advanced Neuroimaging Techniques and Applications
- Congenital Diaphragmatic Hernia Studies
- Spinal Fractures and Fixation Techniques
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Respiratory Support and Mechanisms
- Spine and Intervertebral Disc Pathology
- Prosthetics and Rehabilitation Robotics
- Medical Imaging and Analysis
- Pluripotent Stem Cells Research
- Tracheal and airway disorders
- Neurogenesis and neuroplasticity mechanisms
- Sleep and related disorders
China Rehabilitation Research Center
2014-2024
Chinese Institute for Brain Research
2014-2024
Capital Medical University
2014-2024
Yangzhou University
2024
Alibaba Group (China)
2024
Anhui Institute of Optics and Fine Mechanics
2024
Chinese Academy of Sciences
2024
Air Force Medical University
2015
Taishan Medical University
2014
Hunan Institute of Mental Health
2010
Abstract Background Spinal cord injury (SCI) patients display disruption of gut microbiome, and dysbiosis exacerbate neurological impairment in SCI models. Cumulative data support an important role microbiome SCI. Here, we investigated the hypothesis that fecal microbiota transplantation (FMT) from healthy uninjured mice into may exert a neuroprotective effect. Results FMT facilitated functional recovery, promoted neuronal axonal regeneration, improved animal weight gain metabolic profiling,...
Neurogenic bowel dysfunction (NBD) is a major physical and psychological problem in patients with spinal cord injury (SCI), gut dysbiosis commonly occurs SCI. Here, we document neurogenic management of male chronic traumatic complete SCI our centre perform comparative analysis the microbiota between healthy males. A total 43 (20 quadriplegia 23 paraplegia) adults were enrolled. Clinical data fresh stool specimens collected from all participants. Face-to-face interviews conducted to survey...
Ketamine abuse has been shown to have a deleterious impact on brain function. However, the precise mechanisms of ketamine dependence-induced pathological change remain poorly understood. Although there is evidence for white matter changes in drug abuse, presence abnormalities chronic users not studied. White volumes were measured using vivo diffusion tensor magnetic resonance imaging data 41 ketamine-dependent subjects and 44 drug-free healthy volunteers. associated with use found bilateral...
Spinal cord injury (SCI) disturbs the autonomic nervous system and induces dysfunction in multiple organs/tissues, such as gastrointestinal (GI) system. The neuroprotective effects of melatonin SCI models have been reported; however, it is unclear whether beneficial are associated with alleviation gut dysbiosis. In this study, we showed that daily intraperitoneal injection following spinal contusion at thoracic level 10 mice improved intestinal barrier integrity GI motility, reduced...
Ferroptosis is a recently discovered form of iron-dependent cell death, which occurs during the pathological process various central nervous system diseases or injuries, including secondary spinal cord injury. Selenium has been shown to promote neurological function recovery after cerebral hemorrhage by inhibiting ferroptosis. However, whether selenium can injury as well underlying mechanism remain poorly understood. In this study, we injected sodium selenite (3 µL, 2.5 µM) into site rat...
Spinal cord injury (SCI) is mostly caused by trauma. As primary mechanical unavoidable in SCI, a focus on the pathophysiology and underlying molecular mechanisms of SCI-induced secondary necessary to develop promising treatments for SCI patients. Circular RNAs (circRNAs) are associated with various diseases. Nevertheless, studies date have not yet determined functional roles circRNAs traumatic SCI. We examined circRNA expression profiles contused spinal cords rats using microarray...
Abstract Accurate three-dimensional positioning is fundamental for the safe movement of wheeled robots across multiple floors. However, achieving precise mobile systems in multilevel scenarios using low-cost sensors remains a significant challenge. This paper proposes method based on event-triggered Extended Kalman Filtering (EKF), which integrates data from barometer, Inertial Measurement Unit (IMU), and encoder. Firstly, during movement, collect acceleration barometric pressure data,...
Spinal cord injury (SCI) is mostly caused by trauma. As primary mechanical unavoidable, a focus on the underlying molecular mechanisms of SCI-induced secondary necessary to develop promising treatments for patients with SCI. tRNA-derived small RNA (tsRNA) novel class short, non-coding RNA, possessing potential regulatory functions in various diseases. However, functional roles tsRNAs traumatic SCI have not been determined yet. We used combination sequencing, quantitative reverse...
Abstract Increased mechanical stress after spinal cord injury (SCI) expands the scope of nerve tissue damage and exacerbates function defects. Surgical decompression SCI is a conventional therapeutic strategy has been proven to have neuroprotective effects. However, mechanisms interaction between neurons are currently unknown. In this study, we monitored intramedullary pressure (IMP) investigated benefit (including durotomy piotomy) its underlying in SCI. We found that decreased IMP promotes...
The increase in Cervical Spondylosis cases and the expansion of affected demographic to younger patients have escalated demand for X-ray screening. Challenges include variability imaging technology, differences equipment specifications, diverse experience levels clinicians, which collectively hinder diagnostic accuracy. In response, a deep learning approach utilizing ResNet-34 convolutional neural network has been developed. This model, trained on comprehensive dataset 1235 cervical spine...
The authors report a case of functional improvement the paralyzed diaphragm in high cervical quadriplegia via phrenic nerve neurotization using spinal accessory nerve. Complete cord injury at C-2 level was diagnosed 44-year-old man. Left activity decreased, and right completely paralyzed. When metabolism or (for example, fever, sitting, speech) slightly increased, dyspnea occurred. patient underwent with trapezius branch 11 months postinjury. Four weeks after surgery, training synchronous...
Abstract This study aimed to explore the dynamic diffusion tensor imaging (DTI) of changes in spinal cord contusion using a canine model injury involving rostral and caudal levels. In this study, was established female dogs custom‐made weight‐drop lesion device. DTI performed on with injured cords (n=7) Siemens 3.0T MRI scanner at pre‐contusion 3 h, 24 6 weeks 12 post‐injury. The tissue sections were stained for immunohistochemical analysis. Canine models created successfully fractional...
To investigate the effects of core stability training (CST) on an unstable support surface (USS) balance and ambulation function individuals with chronic spinal cord injury (SCI).Twenty-nine patients SCI were randomly divided into experiment group (N.=14) control (N.=15). The two groups received residual extremity muscle strengthening exercises (REMSE), body weight supported treadmill (BWSTT) CST five times per week for 12 weeks. Patients in implemented a stable (SSS), but created by sling...
Objective: To evaluate the diaphragm thickness and excursion in patients with cervical spinal cord injury reliability of diaphragmatic ultrasonography.
Surgical decompression after spinal cord injury (SCI) is a conventional treatment. Although it has been proven to have clinical effects, there are certain limitations, such as the surgical conditions that must be met and invasive nature of Therefore, an urgent need develop simple maneuverable therapy for emergency treatment patients with SCI before surgery. Rapamycin (RAPA) reported potential therapeutic agent SCI. In this study, we observed effects rapamycin decompression, in combination or...
Compared to healthy controls, spinal cord injury (SCI) patients demonstrated white matter (WM) abnormalities in the brain. However, little progress has been made compare whether cerebral WM differences between SCI-subgroups. The purpose of study was investigate mircrostructure paraplegia and quadriplegia using tract-based spatial statistics (TBSS) atlas-based analysis methods. Twenty-two SCI (11cervical 11 thoracic SCI) 22 age- sex-matched controls were included this study. TBSS analyses...
OBJECTIVE: To investigate trunk muscle activity patterns in a person with thoracic spinal cord injury when walking different un-powered exoskeletons, and to explore how exoskeletons affect patterns. CASE REPORT: Data were recorded from subject complete at T10, using an electromyography system on 4 pairs of muscles motion capture simultaneously. RESULTS: The participant generated large force laterally bend rotate trunk, swung his leg through the moments generated, not only by flexion...