A5073045846- Zoonotic diseases and public health
- Animal Disease Management and Epidemiology
- Retinal Development and Disorders
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Climate Change and Health Impacts
- Viral gastroenteritis research and epidemiology
- Agriculture Sustainability and Environmental Impact
- FinTech, Crowdfunding, Digital Finance
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Economic and Financial Impacts of Cancer
- Cancer-related gene regulation
- Blockchain Technology Applications and Security
- Ethics in Clinical Research
- Hippo pathway signaling and YAP/TAZ
- Advanced Decision-Making Techniques
- Military Defense Systems Analysis
- RNA modifications and cancer
- Health Systems, Economic Evaluations, Quality of Life
- Glaucoma and retinal disorders
- Cancer Cells and Metastasis
- Topic Modeling
- Viral Infections and Vectors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Cell and Gene Therapy Catapult
2024-2025
King's College London
2024-2025
Guy's Hospital
2025
Dassault Systèmes (United States)
2021-2024
Shanghai Jiao Tong University
2022-2024
Shanxi University
2024
University of Manchester
2019-2023
Genomics (United Kingdom)
2022-2023
SAIC-GM (China)
2023
Nantes Université
2022
N6-methyladenosine (m6A) is the most prevalent eukaryotic messenger RNA modification. Diabetic cataract (DC) caused by high glucose (HG) in diabetes mellitus. However, regulatory mechanism of m6A DC pathogenesis poorly understood. In present research, we performed m6A-RNA immunoprecipitation sequencing (MeRIP-Seq) analysis and detected modification profile HG- or normal (NG)-induced human lens epithelial cells (HLECs). Results revealed that methyltransferase-like 3 (METTL3) was upregulated...
The One Health (OH) approach is used to control/prevent zoonotic events. However, there a lack of tools for systematically assessing OH practices. Here, we applied the Global Index (GOHI) evaluate global performance zoonoses (GOHI-Zoonoses). fuzzy analytic hierarchy process algorithm and comparison matrix were calculate weights scores five key indicators, 16 subindicators, 31 datasets 160 countries territories worldwide. distribution GOHI-Zoonoses varies significantly across regions,...
This cohort study evaluates the association of coronavirus disease 2019 (COVID-19) pandemic with clinical research and development for cancer by studying initiation oncology trials over time.
Abstract Background Cancer stem cells (CSCs) are the root of human cancer development and major cause treatment failure. Aberrant elevation SOX4, a member SOX (SRY-related HMG-box) family transcription factors, has been identified in many types promotes development. However, role SOX4 CSCs, especially at proteome-wide level, remained elusive. The aim this study is to investigate effect on stemness CSCs reveal underlying mechanisms by identification SOX4-induced proteome changes through...
Abstract Background Accurately forecasting the prognosis could improve cervical cancer management, however, currently used clinical features are difficult to provide enough information. The aim of this study is capability by developing a miRNAs-based machine learning survival prediction model. Results expression characteristics miRNAs were chosen as for model development. miRNA data was obtained from Cancer Genome Atlas database. Preprocessing, including unquantified removal, missing value...
One Health approach is crucial to tackling complex global public health threats at the interface of humans, animals, and environment. As outlined in Joint Plan Action, international community includes stakeholders from different sectors. Supported by Bill & Melinda Gates Foundation, an academic for action has been proposed with aim promoting understanding real-world implementation contribution towards Sustainable Development Goals a healthy planet.
In the 21st century, as globalization accelerates and global public health crises occur, One Health approach, guided by holistic thinking of human-animal-environment emphasizes interdisciplinary collaboration to address issues, has been strongly advocated international community. An immediate requirement exists for creation an assessment tool foster initiatives on both national scales. Built upon extensive expert consultations dialogues, this follow-up study enhances 2022 Index (GOHI)...
Due to emerging issues such as global climate change and zoonotic disease pandemics, the One Health approach has gained more attention since turn of 21st century. Although thinking deep roots early applications in Chinese history, significant gaps exist China's real-world implementation at complex interface human-animal-environment.We abstracted data from index study analysed performance selected fields based on Structure-Process-Outcome model. By comparing China Belt & Road G20 countries,...
Viral infectious diseases of poverty (vIDPs) remain a significant global health challenge. Despite their profound impact, the burden these is not comprehensively quantified. This study aims to analyze six major vIDPs, including coronavirus disease 2019 (COVID-19), HIV/AIDS, acute hepatitis, dengue, rabies, and Ebola virus (EVD), using data from Global Burden Diseases, Injuries, Risk Factors Study 2021 (GBD 2021).
Purpose: This study aims to reveal the mechanism underlying baicalin-suppressing ovarian cancer stemness. Methods: OVCAR-3 and primary cells were used for cell model. The stem isolated by suspension culture. Cell viability clonogenicity examined CCK-8 assay colony formation assay. self-renewal of was evaluated determination sphere-forming capacity frequency in vitro vivo tumor-initiating cells. mRNA protein levels relatively quantified qRT-PCR Western blot. transcription regulation target...
It is unknown whether Medicaid expansion under the Affordable Care Act (ACA) or state-level policies mandating coverage of routine costs clinical trial participation have ameliorated longstanding racial and ethnic disparities in cancer enrollment.
Cilia function in the left-right organizer (LRO) is critical for determining internal organ asymmetry vertebrates. To further understand genetics of asymmetry, we isolated a mouse mutant with laterality defects, l11Jus27, from random mutagenesis screen. l11Jus27 mutants carry missense mutation pre-mRNA processing factor, Prpf8. cephalophŏnus (cph) zebrafish, carrying protein truncating prpf8, phenocopy defects mutants. Prpf8 and fish embryos have increased expression an alternative...
Stromal/cytoplasmic collagen XIαI (COL11A1) has been highlighted in the process of neoplastic transformation, including epithelial mesenchymal transition (EMT), metastasis and invasiveness. In this study, we aim to illuminate clinical significance biological role COL11A1 esophageal squamous cell carcinoma (ESCC). Herein, investigated expression 16 pairs ESCC adjacent normal tissues by RT-PCR western blotting analysis. Correlations with clinicopathologic parameters survival status were then...
The breast cancer stem cells contribute to the initiation, progression, recurrence, metastasis as well resistance of cancer. However, mechanisms underlying maintenance stemness have not been fully understood.TCGA and GEO data were used for measuring miR-520b expression in tissues. Kaplan-meier analysis was determining relationship between level prognosis patients. Genetic manipulation performed by lentivirus system inhibitor knockdown miR-520b. qRT-PCR Western blot employed determine mRNA...
Abstract Background Data-driven research is a very important component of One Health. As the core part global Health index (GOHI), Intrinsic Drivers (IDI) framework for evaluating baseline conditions human-animal-environment health. This study aims to assess performance in terms GOH-IDI, compare it across different World Bank regions, and analyze relationships between GOH-IDI national economic levels. Methods The raw data among 146 countries were collected from authoritative databases...
Abstract Background Food systems instantiate the complex interdependencies across humans, physical environments, and other organisms. Applying One Health approaches for agri-food system transformation, which adopts integrated unifying to optimize overall health of animals, plants, is crucial enhance sustainability food systems. This study develops a potential assessment tool, named global index-Food Security (GOHI-FS), aiming evaluate security performance countries/territories from...
One Health has become a global consensus to deal with complex health problems. However, the progress of implementation in many countries is still relatively slow, and there lack systematic evaluation index. The purpose this study was establish an indicator framework for Intrinsic Drivers index (GOH-IDI) evaluate human, animal environmental development process globally. First, 82 studies were deeply analyzed by grounded theory (GT) method, including open coding, axial selective three-level...
The rapid acceleration of global warming has led to an increased burden high temperature-related diseases (HTDs), highlighting the need for advanced evidence-based management strategies. We have developed a conceptual framework aimed at alleviating HTDs, grounded in One Health concept. This refines impact pathway and establishes systematic data-driven models inform adoption decision-making, tailored distinct contexts. collected extensive national-level data from authoritative public...