A5102016609- Cancer-related molecular mechanisms research
- Genetic Neurodegenerative Diseases
- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
- Cervical Cancer and HPV Research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Cancer Mechanisms and Therapy
- Barrier Structure and Function Studies
- Endometrial and Cervical Cancer Treatments
- Muscle Physiology and Disorders
- Cancer Treatment and Pharmacology
- Neonatal Respiratory Health Research
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Bioactive Compounds and Antitumor Agents
- Protein Tyrosine Phosphatases
- Hereditary Neurological Disorders
- Syphilis Diagnosis and Treatment
- Chromatin Remodeling and Cancer
Tongji Hospital
2020-2024
Huazhong University of Science and Technology
2012-2024
Union Hospital
2024
Union Hospital
2023-2024
Central South University
2017-2024
Second Xiangya Hospital of Central South University
2017
Although research on the effects of comorbidities coronavirus disease 2019 (COVID-19) patients is increasing, risk cancer history has not been evaluated for mortality with COVID-19.In this retrospective study, we included 3232 pathogen-confirmed COVID-19 who were hospitalized between January 18th and March 27th, 2020, at Tongji Hospital in Wuhan, China. Propensity score matching was used to minimize selection bias.In total, 2665 complete clinical outcomes analyzed. The impacts age, sex,...
The effective treatment of advanced cervical cancer remains challenging. Herein, single-nucleus RNA sequencing (snRNA-seq) and SpaTial enhanced resolution omics-sequencing (Stereo-seq) are used to investigate the immunological microenvironment squamous cell carcinoma (CSCC). expression levels most immune suppressive genes in tumor inflammation areas CSCC not significantly higher than those non-cancer samples, except for LGALS9 IDO1. Stronger signals CD56
Autophagy is an important intracellular catabolic mechanism involved in the removal of misfolded proteins. Atg14L, mammalian ortholog Atg14 yeast and a critical regulator autophagy, mediates production PtdIns3P to initiate formation autophagosomes. However, it not clear how Atg14L regulated. In this study, we demonstrate that ubiquitination degradation controlled by ZBTB16-Cullin3-Roc1 E3 ubiquitin ligase complex. Furthermore, show wide range G-protein-coupled receptor (GPCR) ligands...
Human papillomavirus (HPV) is predominantly associated with HPV-related cancers, however, the precise mechanisms underlying HPV-host epigenetic architectures in HPV carcinogenesis remain elusive. Here, we employed high-throughput chromosome conformation capture (Hi-C) to comprehensively map HPV16/18-host chromatin interactions. Our study identified transcription factor Sp1 as a pivotal mediator programming By targeting Sp1, active histone modifications (H3K27ac, H3K4me1, and H3K4me3)...
Abstract Cervical carcinoma is a serious type of gynecological cancer that can affect women all ages. presents challenges for precision medicine, as not tumors have specific gene mutations or alterations be targeted with existing drugs. Nonetheless, there are some promising targets in cervical carcinoma. Herein, genomic mutation data from The Cancer Genome Atlas and Catalogue Somatic Mutations were used to identify PIK3CA was the most mutant among targets, especially squamous cell carcinoma,...
Abstract Integration of human papilloma virus (HPV) DNA into the genome may progressively contribute to cervical carcinogenesis. To explore how HPV integration affects gene expression by altering methylation during carcinogenesis, we analyzed a multiomics dataset for cancer. We obtained data HPV‐capture sequencing, RNA and Whole Genome Bisulfite Sequencing from 50 patients with detected 985 485 HPV‐integration sites in matched tumor adjacent paratumor tissues. Of these, LINC00486 ( n = 19),...
Background The claudin family is a group of transmembrane proteins related to tight junctions. While their involvement in cancer has been studied extensively, relationship with the tumor immune microenvironment remains poorly understood. In this research, we focused on genes prognosis ovarian and explored microenvironment. Methods cBioPortal for Cancer Genomics database was used obtain genetic variation pattern cancer. ONCOMINE Gene Expression Profiling Interactive Analysis (GEPIA) databases...
Iron accumulation in basal ganglia accompanies neuronal loss Huntington's disease (HD) patients and mouse models. Disruption of HD brain iron homeostasis occurs before the onset clinical signs. Therefore, investigating mechanism is essential to understanding its role pathogenesis. N171-82Q transgenic mice was detected by using Diaminobenzidine-enhanced Perls' stain. homeostatic proteins including response protein 1 (IRP1), transferrin (Tf), ferritin receptor (TfR) were determined western...
Abstract Human papillomavirus (HPV) integration and high expression of HPV oncogenes ( E6 E7 ) are important mechanisms for carcinogenesis in cervical cancer. However, the relationship between spliced transcripts, as well underlying after splicing remains unclear. We analyzed HPV‐coiled‐coil domain containing 106 CCDC106 samples to characterize roles integration, spliceosome I (E6*I), carcinogenesis. found that was alternatively into E6*I transcript HPV‐ CCDC016 with low p53 expression,...
Abstract Huntington's disease (HD) is an inherited neurodegenerative that caused by the abnormal expansion of CAG repeats in gene encoding huntingtin (Htt). Reduced AKT phosphorylation and inhibited activity have been shown to be involved mutant Htt (mHtt)‐induced cell death. Lycium barbarum polysaccharide (LBP), main bioactive component , reportedly has neuroprotective roles neural injuries, including diseases. Here, we report treatment with LBP can increased viability HEK293 cells stably...
Lysyl oxidase-like 2 (LOXL2) is a member of the lysine oxidase (LOX) family. Although its overexpression known to play pivotal roles in carcinogenesis, involvement cervical cancer remains undefined. Here, we comprehensively explored expression level and functional mechanism LOXL2 using bioinformatics experimental methods. Bioinformatics analysis revealed that was significantly upregulated compared normal tissues. Enrichment showed most positively or negatively correlated genes were with...
Despite the differences in disease outcomes and pathological features between cervical squamous cell carcinoma (CSCC) adenocarcinoma (ADC), molecular characteristics immune heterogeneity of tumor microenvironment remain unclear. Here, we explored landscape CSCC ADC. Gene expression clinical from The Cancer Genome Atlas (TCGA) were downloaded. Differentially expressed genes (DEGs), infiltration, pathway enrichment analyses used to explore Furthermore, distinct signatures ADC validated based...
Abstract Cervical cancer remains one of the most lethal gynecological malignancies. However, biomarkers for more precise patient care are an unmet need. Herein, concentration 285 plasma cell‐free DNA (cfDNA) samples analyzed from 84 cervical patients and clinical significance cfDNA fragmentomic characteristics across neoadjuvant chemotherapy (NACT) treatment. Patients with poor NACT response exhibit a significantly greater escalation in levels following initial cycle treatment, comparison to...
Abstract Purpose: Several RAB family genes have been studied extensively and proven to play pivotal roles in the occurrence development of certain cancers. Here, we explored commonly expressed humans their prognostic significance using bioinformatics, then identified potential biomarkers breast invasive carcinoma (BRCA). Materials methods: The values (overall survival) BRCA were obtained Gene Expression Profiling Interactive Analysis (GEPIA). expression patterns relationships with...
BackgroundKidney renal clear cell carcinoma (KIRC) is the most common pathological subtype of cancer. APOBEC3 activity has been identified in a variety human cancers. Although its involvement cancer studied widely, influence on tumor immune microenvironment remains poorly understood. Therefore, this study aimed to focus effect KIRC.MethodsIn study, we comprehensively analyzed expression and prognostic significance family pan-cancer using multiple databases. The functions key members were...
Huntingtin-associated protein-1 (HAP1) was initially identified as a binding partner of huntingtin, the Huntington's disease protein. Based on its preferred distribution among neurons and endocrine cells, HAP1 has been suggested to play roles in vesicular transportation hormonal secretion cells. Given that is selectively expressed islets rat pancreas, this study, we analyzed expression pattern islets. In rats injected intraperitoneally with streptozotocin, which can destroy β-cells...