A5101982875- interferon and immune responses
- Immune Response and Inflammation
- GABA and Rice Research
- Plant Gene Expression Analysis
- Plant Stress Responses and Tolerance
- Plant biochemistry and biosynthesis
- Plant responses to water stress
- RNA regulation and disease
- Plant Molecular Biology Research
- COVID-19 Clinical Research Studies
- Aquaculture disease management and microbiota
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Photosynthetic Processes and Mechanisms
- Plant Micronutrient Interactions and Effects
- Microbial Metabolic Engineering and Bioproduction
- Plant nutrient uptake and metabolism
- Respiratory viral infections research
- Cancer-related gene regulation
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
- Nuclear Structure and Function
- Light effects on plants
- Microtubule and mitosis dynamics
- Trace Elements in Health
Huadong Hospital
2022-2023
Fudan University
2020-2023
Shanghai Xuhui Central Hospital
2023
Shanghai Stomatological Hospital
2023
Hainan University
2021-2023
Sanya University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Children's Hospital of Fudan University
2022
Huazhong Agricultural University
2018-2020
University of Alberta
2020
Coronavirus disease 2019 (COVID-19) is a current global health threat caused by the novel coronavirus severe acute respiratory syndrome 2 (SARS-CoV-2). Emerging evidence indicates that SARS-CoV-2 elicits dysregulated immune response and delayed interferon (IFN) expression in patients, which contribute largely to viral pathogenesis development of COVID-19. However, underlying mechanisms remain be elucidated. Here, we report activation repression innate SARS-CoV-2. We show RNA activates...
Copper (Cu) is an essential micronutrient for plant growth. However, the molecular mechanisms underlying Cu trafficking and distribution to different organs in rice (Oryza sativa) are poorly understood. Here, we report function role of Antioxidant Protein1 (OsATX1), a chaperone rice. Knocking out OsATX1 resulted increased concentrations roots, whereas overexpression reduced root but accumulation shoots. At reproductive stage, developing tissues, including panicles, upper nodes internodes,...
Innate immunity plays a pivotal role in virus infection. RIG-I senses viral RNA and initiates an effective innate immune response for type I interferon production. To transduce RIG-I-mediated antiviral signalling, mitochondrial protein MAVS forms prion-like aggregates to activate downstream kinases transcription factors. However, the activation mechanism of is incompletely understood. Here we identify two ubiquitin enzymes Ube2D3 Ube2N through chromatographic purification as activators on We...
Summary Salt stress negatively affects rice growth, development and yield. Metabolic adjustments contribute to the adaptation of under salt stress. Branched‐chain amino acids (BCAA) are three essential that cannot be synthesized by humans or animals. However, little is known about role BCAA in response plants. Here, we showed BCAAs may function as scavengers reactive oxygen species (ROS) provide protection against damage caused salinity. We determined branched‐chain aminotransferase 2...
Abstract In response to virus infection, RIG-I-like receptors (RLRs) sense RNA and induce MAVS form prion-like aggregates further propagate antiviral signalling. Although monomeric recombinant protein can assemble into filaments spontaneously in vitro , endogenous cells is prevented from aggregation until viral infection. The mechanism preventing cellular spontaneous unclear. Here we show that multiple N-terminal truncated isoforms of are essential full-length through transmembrane...
Grain essential amino acid (EAA) levels contribute to rice nutritional quality. However, the molecular mechanisms underlying EAA accumulation and natural variation in grains remain unclear. Here we report identification of a previously unrecognized auxin influx carrier subfamily gene, OsAUX5, which encodes an transporter that functions uptake multiple acids. We identified elite haplotype Pro::OsAUX5Hap2 enhances grain without apparent negative effect on agronomic traits. Natural variations...
Summary Branched‐chain amino acids (BCAAs) are essential that must be obtained from the diet for humans and animals, they play important roles in various aspects of plant growth development. Although BCAA biosynthetic pathways higher plants have been uncovered, knowledge their genetic control is still limited, no positive regulators identified to date. Here, we showed variation levels rice attributable differential transcription OsbZIP18 , a basic leucine zipper (bZIP) factor, due...
Serotonin (5-hydroxytryptamine) plays an important role in many developmental processes and biotic/abiotic stress responses plants. Although serotonin biosynthetic pathways plants have been uncovered, knowledge of the mechanisms accumulation is still limited, no regulators identified to date. Here, we basic leucine zipper transcription factor OsbZIP18 as a positive regulator biosynthesis rice. Overexpression strongly induced levels its early precursors (tryptophan tryptamine), resulting...
Abstract Somatic loss-of-function mutations of the dioxygenase Ten-eleven translocation-2 (TET2) occur frequently in individuals with clonal hematopoiesis (CH) and acute myeloid leukemia (AML). These common hematopoietic disorders can be recapitulated mouse models. However, underlying mechanisms by which deficiency TET2 promotes these remain unclear. Here we show that cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator interferon genes (STING) pathway is...
Abstract In response to virus infection, RIG-I senses viral RNA and activates the adaptor protein MAVS, which then forms prion-like filaments stimulates a specific signalling pathway leading type I interferon production restrict proliferation. However, mechanisms by MAVS activity is regulated remain elusive. Here we identify distinct regions of responsible for activation transcription factors regulatory factor 3 (IRF3) nuclear kappa-light-chain-enhancer activated B cells (NF-κB). These IRF3-...
Cell migration occurs in confined microenvironments, which plays a vital role the process of tumor metastasis. However, it is challenging to study their behaviors vivo. Here we developed cell squeeze system that can be scaled down micrometers mimic native physical wherein degrees surface adhesion and mechanical constraints could manipulated order investigate cell-migrating behaviors. Based on microscale system, found synergistic lamin A/C vimentin transition under strong confinement. The...
A wide variety of metabolic gene clusters exist in eukaryotic genomes, but fatty acid have not been discovered. Here, combining with and phenotypic genome-wide association studies, we identify a major locus containing six-gene cluster on chromosome 3 (FGC3) that controls the cutin monomer hydroxymonoacylglycerols (HMGs) contents rice yield, possibly through variation transcription FGC3 members. We show HMGs are sequentially synthesized endoplasmic reticulum by OsFAR2, OsKCS11, OsGPAT6,...
Aeromonas hydrophila is an opportunistic pathogen of a variety aquatic animals that displays extreme diversity in drug resistance, phenotypes, virulence genes, and virulence. In this study, eight pathogenic A. strains were isolated from diseased Amur sturgeons investigated for their sensitivity to select antibiotics, phenotype, According the phylogenetic analysis DNA gyrase subunit B protein, isolates formed single branch group. The antibiotics ceftazidime, cefuroxime, cefoperazone,...
The monomer-to-filament transition of MAVS is essential for the RIG-I/MDA5-mediated antiviral signaling. In quiescent cells, monomeric under strict regulation preventing its spontaneous aggregation, which would result in dysregulated interferon (IFN-α/β) production and autoimmune diseases like systemic lupus erythematosus. However, detailed mechanism by kept from aggregation remains largely unclear. Here, we show that upstream open reading frames (uORFs) within transcripts exert a...
Salinity is an important environmental factor influencing crop growth and yield. Malate dehydrogenase (MDH) catalyses the reversible conversion of oxaloacetate (OAA) to malate. While many MDHs have been identified in various plants, biochemical function MDH rice remains uncharacterised, its role salt stress response largely unexplored. In this study, OsMDH12 was determined, revealing involvement regulating tiller number tolerance rice. localises peroxisome expressed across organs. vitro...
患儿 男，3岁10月龄，因“间歇发热2周伴咳嗽、气促”入上海交通大学医学院附属仁济医院（南部院区）定点医院隔离病房。患儿病初发热，确诊为新型冠状病毒肺炎（简称新冠肺炎），热退2 d再次持续高热>3 d伴气促、吸气性凹陷，胸部CT示右肺下叶片状密度影，诊断“重型新冠肺炎”，行支气管镜肺泡灌洗，宏基因组病原检测确诊为混合肺炎支原体感染，治疗好转出院。提示临床医生诊治重型新冠肺炎时需警惕混合感染。.
Objective: To investigate the clinical features of children with chronic nonbacterial osteomyelitis (CNO), and raise awareness among clinicians. Methods: In this retrospective study, 18 patients CNO who were diagnosed in Children's Hospital Fudan University from January 2015 to December 2021 included. Results: Eighteen (12 males, 6 females) identified. Their age at onset was 9 (5, 11) years, delay diagnosis 2 (1, 6) months, follow-up-was 17 (8, 34) months. The most common symptoms fever 14...