A5100451342- Soil Carbon and Nitrogen Dynamics
- Rangeland Management and Livestock Ecology
- Advanced biosensing and bioanalysis techniques
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Soil erosion and sediment transport
- Microbial Community Ecology and Physiology
- Solar Thermal and Photovoltaic Systems
- Pharmacological Effects of Natural Compounds
- Plant Water Relations and Carbon Dynamics
- Microbial metabolism and enzyme function
- Legume Nitrogen Fixing Symbiosis
- Ecology and Vegetation Dynamics Studies
- RNA Interference and Gene Delivery
- Fire effects on ecosystems
- Genomics and Phylogenetic Studies
- Botany and Plant Ecology Studies
- Cancer, Hypoxia, and Metabolism
- Building Energy and Comfort Optimization
- Solar Energy Systems and Technologies
- Yersinia bacterium, plague, ectoparasites research
- Pasture and Agricultural Systems
- Seed Germination and Physiology
- Biochemical Acid Research Studies
- Listeria monocytogenes in Food Safety
Northwest Institute of Eco-Environment and Resources
2018-2025
Chinese Academy of Sciences
2018-2025
University of Chinese Academy of Sciences
2018-2025
Shanghai Jiao Tong University
2024-2025
Shanghai Sixth People's Hospital
2024-2025
Jiangnan University
2024-2025
Ministry of Natural Resources
2024
First Affiliated Hospital Zhejiang University
2021-2024
Dalian Ocean University
2024
Shandong First Medical University
2024
Abstract It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble from embryos. Here, we report a chemical cocktail enables the derivation of totipotent-like cells, designated as potential (TPS) 2-cell mouse embryos extended pluripotent these TPS can be stably maintained long term vitro. shared features with terms totipotency markers, transcriptome, chromatin accessibility DNA methylation patterns. In vivo chimera formation assays show have...
BACKGROUND:A variety of treatment strategies have been developed for clear cell kidney carcinoma (KIRC); however, there is still a need effective therapeutic targets and prognostic molecular biomarkers. Given that long noncoding RNAs (lncRNAs) has emerging as an important regulator in tumorigenesis, we explored potential functional lncRNAs KIRC by comprehensively analyzing the lncRNA–miRNA–mRNA regulatory network with bioinformatics processing tools. MATERIAL AND METHODS:RNA-seq/miRNA-seq...
Pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase 1 (PHLPP1) is a kind of serine/threonine phosphatase, whose dysregulation accompanied with numerous human diseases. However, its role in diabetic cardiomyopathy remains unclear. We explored the underlying function and mechanism PHLPP1 (DCM).In vivo, Type rats were induced by intraperitoneal injection 60 mg/kg streptozotocin (STZ). Lentivirus-mediated short hairpin RNA (shRNA) was used to knock down expression PHLPP1. In...
Objectives Inflammatory bowel disease (IBD) is a chronic lifelong inflammatory disease. Probiotics such as Bifidobacterium longum are considered to be beneficial the recovery of intestinal inflammation by interaction with gut microbiota. Our goals were define effect exclusive use BAA2573 on dextran sulfate sodium (DSS)-induced colitis, including improvement symptoms, alleviation histopathological damage, and modulation Methods In present study, we pretreated C57BL/6J mice BAA2573, one main...
Highlights•TUDCA alleviated atherosclerosis and promoted cholesterol efflux capacity of macrophages•TUDCA inhibited activation the PERK/eIF2α/ATF4 AIM2 inflammasome•ATF4 affected transcriptional activity AIM2•AIM2 mediated foam cell formation by targeting ABCA1SummaryCholesterol (CEC) dysfunction in macrophages is important atherosclerosis. However, mechanism underlying CEC remains unclear. We described characteristics ATF4 inflammasome during through scRNA sequencing analysis. Then model...
Abstract Plant diversity loss caused by climate change decreases soil organic carbon (SOC) sequestration, but the mechanism involved remains unclear. Investigating changes in microbial necromass (MNC) accumulation along a climate–plant species gradient can help clarify this mechanism, as it is crucial for stability of SOC. We conducted large‐scale sampling across 2500‐km transect through grasslands on Tibetan Plateau to investigate MNC content and its contribution SOC at depths 0–20 20–40 cm...