A5024581952- Autoimmune and Inflammatory Disorders Research
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Metabolomics and Mass Spectrometry Studies
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Connective tissue disorders research
- T-cell and B-cell Immunology
- Fibroblast Growth Factor Research
- interferon and immune responses
- Arsenic contamination and mitigation
- Connective Tissue Growth Factor Research
Shanghai Jiao Tong University
2024
Huazhong University of Science and Technology
2024
Renji Hospital
2024
Wenzhou Medical University
2018-2021
Objective Treg/Th17 imbalance plays an important role in rheumatoid arthritis (RA). Maresin 1 (MaR1) prompts inflammation resolution and regulates immune responses. We explored the effect of MaR1 on RA progression investigated correlation between balance. Methods Both patients with healthy controls were recruited into study. Collagen-induced (CIA) model was constructed to detect clinical score, histopathological changes ratio. Purified naive CD4+ T-cells used study its differentiation...
Abstract Regulatory T-cell (Treg)/T-helper 17 (T h 17) cell balance plays an important role in the progression of rheumatoid arthritis (RA). Our study explored protective effect protectin DX (PDX), which restored Treg/T RA, and nucleotide-binding domain (NOD)–like receptor protein 3 (NLRP3) inflammasome pathway this process. Using mass spectrometry, we discovered that level PDX decreased active-RA patients increased inactive-RA compared with HCs, serum was a potential biomarker RA activity...
Abstract Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint stiffness, finally leading to tissue destruction. Connective growth factor (CTGF) critical in RA progression, which promotes fibroblast-like synoviocyte (FLS) proliferation, pannus formation, the damage of cartilage as well bone. Resolvin D1 (RvD1) can promote resolution acute inflammatory diseases, recently, effects RvD1 on diseases also attracted attention. This study aimed...
Abstract Endometrial cancer (EC) stands as the most prevalent gynecological tumor in women worldwide. Notably, differentiation diagnosis of abnormity detected by ultrasound findings (e.g., thickened endometrium or mass uterine cavity) is essential and remains challenging clinical practice. Herein, we identified a metabolic biomarker panel for EC using machine learning high-performance serum fingerprints (SMFs) validated biological function. We first recorded SMFs 191 204 Non-EC subjects via...
Objective: Tofacitinib (TOF) is a Janus kinase (JAK) inhibitor used in the treatment of rheumatoid arthritis (RA), but mechanism its action remains unclear. In this study, we investigated influence TOF on gamma delta regulatory T-cell (γδTreg)/γδT17 cell balance RA and role nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome process. Methods: We detected levels inflammatory factors serum patients before after administration using an enzyme-linked immunosorbent assay...
Emerging evidence has linked arsenic exposure and metabolic homeostasis, but the mechanism is incompletely understood, especially at relatively low concentrations. In this study, we used a mouse model to evaluate health impacts toxicity of in drinking water environmentally relevant levels (0.25 1.0 ppm). Our results indicated that damaged intestinal barrier induced accumulation, oxidative stress, pathological changes liver illum. Interestingly, increased hepatic triglyceride (TG) total...