A5023401063- Bladder and Urothelial Cancer Treatments
- Probiotics and Fermented Foods
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Bone health and treatments
- Banana Cultivation and Research
- Microencapsulation and Drying Processes
- DNA and Biological Computing
- Microbial Metabolites in Food Biotechnology
- RNA Research and Splicing
- Neurological Disorders and Treatments
- MRI in cancer diagnosis
- Cancer Immunotherapy and Biomarkers
- Medicinal Plants and Neuroprotection
- Soybean genetics and cultivation
- Legume Nitrogen Fixing Symbiosis
- Prostate Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Natural Compounds in Disease Treatment
Xijing Hospital
2016-2024
Air Force Medical University
2016-2024
University of Science and Technology of China
2024
Chinese Academy of Sciences
2024
Shanghai Center For Bioinformation Technology
2024
Beijing Institute of Genomics
2024
China Medical University
2024
Xi'an Chest Hospital
2023
Guangxi Academy of Agricultural Science
2021
Biotechnology Research Institute
2021
Women undergoing chemotherapy for the treatment of breast cancer have frequently reported unmet supportive care needs. Moreover, easily accessible and innovative support is lacking.The purpose this trial was to determine effectiveness an app-based e-support program address women's self-efficacy (primary outcome), social support, symptom distress, quality life, anxiety, depression. Secondary objectives included exploring association between health outcomes usage data.A multicenter,...
In the present study, effects of exopolysaccharides (EPS) from nine Lactobacillus strains with a high degree bio‑activity on human colon cancer cell line HT‑29 were studied. The extracellular polymeric substances 4 strains, namely K11, M5, SB27 and X12, displayed desirable anti‑proliferative activity against cells. Crude acidic EPS purified inhibitory further investigated. crude these exerted anti‑proliferation cells in dose‑dependent manner but nontoxic to Vero Treatment significantly...
Bladder cancer (BCa) threatens human health due to the high occurrence and mortality. Nowadays, more researchers focussed on molecular mechanisms biological functions of miRNAs in cancers. The present study aims role miR-454-3p miR-374b-5p BCa. expression levels were detected BCa tissues cell lines by qRT-PCR analysis. Kaplan-Meier analysis revealed that positively correlated with overall survival (OS) rate patients. Gain-of-function assays conducted demonstrate inhibitory effects invasion,...
Abstract Bladder cancer (BCa) is one of the most common malignancies worldwide. Although multiple efforts have been made, 5‐year survival rate patients with BCa remains unchanged in recent years. Overexpression epidermal growth factor receptor (EGFR) found ≈74% tissue specimens; however, current EGFR‐based targeted therapies show little benefit for patients, as EGFR downstream pathways appear to be circumvented by other tyrosine kinases (RTKs). In this study, two natural products are...
Nobiletin is a polymethoxy flavonoid isolated from Citrus depressa and reticulata. It has been reported that nobiletin can suppress tumors. We primarily explored the antitumor effects of associated potential mechanisms in ACHN Caki-2 renal carcinoma cells. A CCK-8 assay cloning experiments were used to assess cell viability, transwell scratch test metastatic ability. The cycle was analyzed by flow cytometry, whereas apoptosis using cytometry terminal dexynucleotidyl transferase...
Hippocampal neuron death is a key factor in vascular dementia (VD) induced by chronic cerebral hypoperfusion (CCH). Dl-3-n-butylphthalide (NBP) multiple-effects drug. Therefore, the potential molecular mechanisms underlying CCH and its feasible treatment should be investigated. This study had two main purposes: first, to identify biomarker rat model of VD using antibody microarrays, second, explore neuroprotective role NBP at targeting biomarker. Glial cell line-derived neurotrophic...
Abstract Controversies exist between the previous two prognostic nomograms for patients with bone metastatic prostate cancer (PCa), and a nomogram applied to western has yet be established. Thus, we aimed build reliable generic individualize prognosis. The independent factors were identified in retrospective study of 1556 PCa registered Surveillance, Epidemiology End Results (SEER) database. Besides, was developed using R software according result multivariable Cox regression analysis. Then,...
Abstract The application of endophytic bacteria, particularly members the genus Bacillus , offers a promising strategy for biocontrol plant fungal diseases, owing to their sustainability and ecological safety. Although multiple secondary metabolites that demonstrate antifungal capacity have been identified in diverse regulatory mechanisms biosynthesis remain largely unknown. To elucidate this, we sequenced entire genome amyloliquefaciens GKT04, strain isolated from banana root, which showed...
Chronic cerebral hypoperfusion (CCH) is induced by chronic deficit of brain perfusion, contributes to a persistent or progressive cognitive dysfunction, which characterized diverse neuropathological manifestations. There are currently no effective medications available. White matter damage (WMD) and cortical neuron death may be caused CCH, related impairment, while the underlying molecular mechanisms remain unclear. In study, database transcriptome level was built determine potential...
Backgrounds: A number of genetic and biological phenomena imply that tumorigenesis clear cell renal carcinoma (ccRCC) is highly correlated with hypoxia-induced factor-1a (HIF-1α).Recently, research focusing on the post-transcriptional regulation HIF-1α has provided a new perspective for ccRCC therapy.In this study, we observed expression pattern RNA-binding protein QKI, which could regulate HIF in both vitro vivo.Methods: Tissue microarraywas subjected to immunohistochemistry tumour lines...
Near-infrared fluorescence (NIRF) imaging is a novel modality that allows for detection and real‑time monitoring of various pathophysiological states. IR-780 iodide has been used as an ideal platform to construct theranostic agents cancer therapy. Abiraterone 17α‑hydroxylase/C17, 20‑lyase (CYP17) inhibitor approved use in patients with prostate after androgen deprivation We report the synthesis characterization conjugated abiraterone dual purpose The new compound Abi-780 retained excellent...
To explore quality of life (QOL) in patients with colorectal cancer and a stoma factors associated their QOL.A quantitative cross-sectional study was carried out the wound care clinic hospital China. Participants were recruited from patients. Investigators collected demographic data clinical information; QOL measured using Chinese version stoma-QOL scale.In total, 359 participants took part; 161 (44.8%) had an ileostomy, whereas others colostomy, about half (46.5%) permanent stoma. The mean...
Previous findings have demonstrated, in a rat model, that chronic cerebral hypoperfusion (CCH) decreases cortical blood flow (CBF) while Dl-3-n-Butylphthalide (DNB) accelerates the timely recovery of CBF. However, potential biomarkers, therapeutic targets, and underlying mechanisms for these processes are unclear. In this study, solid-phase antibody microarray simultaneously detecting multiple proteins was used to search cortex biotargets CCH compared sham control group, results were further...
Renal cell carcinoma (RCC) has always been considered resistant to chemotherapy. IR-780 is a near-infrared fluorescent (NIRF) dye that can be efficiently taken up by RCC cells. Cabazitaxel cytotoxic drug interferes with mitosis acting on tubulin. We chemically fused and cabazitaxel into new drug, Caba-780, which expected increase the sensitivity of Infrared spectrum, nuclear magnetic resonance spectra, high-resolution mass IR spectra were used for detecting structural characterization...
Chronic cerebral hypoperfusion (CCH) contributes to cognitive impairments, and hippocampal neuronal death is one of the key factors involved in this process. Dl-3-n-butylphthalide (D3NB) a synthetic compound originally isolated from seeds Apium graveolens , which exhibits neuroprotective effects against some neurological diseases. However, protective mechanisms D3NB CCH model mimicking vascular impairment remains be explored. We induced rats by bilateral common carotid artery occlusion...
Bladder cancer (BC) is the tenth most common malignancy globally. Urothelial carcinoma (UC) a major type of BC, and advanced UC (aUC) associated with poor clinical outcomes limited survival rates. Current options for aUC treatment mainly include chemotherapy immunotherapy. These have moderate efficacy modest impact on overall thus highlight need novel therapeutic approaches. patients harbor high tumor mutation burden abundant molecular alterations, which are basis targeted therapies....
Multidrug-resistant
Contact inhibition adjusts organ size to the proper and ensures cultured cells growing a monolayer.By regulating downstream coordinator YAP, evolutionarily conserved Hippo transduction pathway attunes cell growth death in response contact inhibition, polarity, self-renewal, differentiation.Dysregulation of this is involved various diseases such as cancer.RNA-binding protein QKI regulates proliferation, metabolism, division, immunity cancer models, but its role remains unclear.In study, we...
The heat-resistant lipases from psychrotrophic bacteria play a major role in the deterioration of dairy products during storage and shelf life. aim this study was to analyze predominant their with relevance preserve quality products. Three bovine raw milk samples collected North China were screened for presence lipolytic bacteria. Overall, 21 isolates selected as potential lipase producers further identified Pseudomonas. Although each geographical area characterized by its own unique...