A5101793222- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Brain Metastases and Treatment
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Chronic Myeloid Leukemia Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Immune cells in cancer
- Radiopharmaceutical Chemistry and Applications
- Radiation Therapy and Dosimetry
- Liver physiology and pathology
- Microplastics and Plastic Pollution
- Graphene and Nanomaterials Applications
- Photodynamic Therapy Research Studies
- Multiple and Secondary Primary Cancers
- Genomics and Rare Diseases
First Hospital of Jilin University
2017-2024
Jilin University
2017-2024
Shanxi Medical University
2024
Duke University
2024
Air Force Medical University
2010-2023
Xijing Hospital
2010-2023
First Bethune Hospital of Jilin University
2017
Xian Mental Health Center
2013
Xi'an Chest Hospital
2007-2011
Chinese People's Liberation Army
2010
Infertility is a common complication in diabetic men, mainly due to the loss of germ cells by apoptotic cell death. However, effective and safe approaches prevent induction testicular apoptosis for patients have not been available. Resveratrol (RSV), group compounds called polyphenols from plants, has indicated its promising used clinically cancers cardiovascular diseases. Therefore, present study aimed determining whether RSV attenuates type 1 diabetes (T1D)-induced death mouse model. We...
The CRISPR-associated Cas9 system can modulate disease-causing alleles both in vivo and ex vivo, raising the possibility of therapeutic genome editing. In addition to gene targeting, epigenetic modulation by catalytically inactive dCas9 may also be a potential form cancer therapy. Granulin (GRN), potent pluripotent mitogen growth factor that promotes progression maintaining self-renewal hepatic stem cells, is upregulated hepatoma tissues associated with decreased tumor survival patients...
Although surgery offers the only hope of cure for hepatocellular carcinoma (HCC), patients with inoperable or metastatic disease have a dismal prognosis. Therefore, there is an urgent need new and effective treatment strategies. Polymeric micelles composed drug conjugated to diblock copolymer attracted great interest clinical administration anticancer drugs. In this work, characteristics cytotoxicity doxorubicin-poly(d,l-lactic-co-glycolic acid)-poly(ethylene glycol) (DOX-PLGA-PEG) micelle...
Background and Objective: The inability of radiotherapy to eradicate completely certain human tumours may be due the presence resistant hypoxic cells. Several studies have confirmed radiosensitizing effect paclitaxel, a microtubular inhibitor. object this study was evaluate physicochemical characteristics paclitaxel-loaded nanoparticles, determine ability released paclitaxel radiosensitize breast carcinoma cells (MCF-7) with respect radiation dose. Methods: poly(d,l-lactide-co-glycolide)...
Hepatocellular carcinoma (HCC) shows low response to most conventional treatment strategies. Therefore, there is an urgent need for new and effective chemotherapies. Nanotechnology gives a dramatic impact on medicine. In this work, paclitaxel loaded nanoparticles (NPs) decorated with bivalent fragment HAb18 F(ab')2 and/or cell penetrating peptide (CPP) were developed evaluated. NPs prepared by emulsification-solvent evaporation method carbodiimide chemistry. The physicochemical...
Radioresistant hypoxic cells may contribute to the failure of radiation therapy in controlling certain tumors. Some studies have suggested radiosensitizing effect paclitaxel. The poly (D,L-lactide-co-glycolide)(PLGA) nanoparticles containing paclitaxel were prepared by o/w emulsification-solvent evaporation method. physicochemical characteristics (i.e., encapsulation efficiency, particle size distribution, morphology, vitro release) studied. morphology two human tumor cell lines: a carcinoma...
Abstract Purpose Nonsmall cell lung cancer (NSCLC) patients with brain metastases (BM) have a poor prognosis. Despite the traditional methods including radiotherapy and chemotherapy, epidermal growth factor receptor‐tyrosine kinase inhibitors (EGFR‐TKIs) might benefit on survival quality of life. We investigated cost‐effectiveness icotinib compared whole‐brain irradiation (WBI) or without chemotherapy for NSCLC BM. Materials A Markov model was conducted based data BRAIN trial. economic...
The prognosis of B-cell acute lymphoblastic leukemia (B-ALL) has improved significantly with current first-line therapy, although the recurrence B-ALL is still a problem. Toll-like receptor 9 (TLR9) agonists have shown good safety and efficiency as immune adjuvants. Apart from their regulatory effect, direct effect TLR9 on cancer cells expression cannot be ignored. However, remains unknown.We discussed relationship between clinical characteristics explored whether CpG 685 exerts apoptotic...