A5100688711- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- RNA Interference and Gene Delivery
- Carcinogens and Genotoxicity Assessment
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Dental Implant Techniques and Outcomes
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Periodontal Regeneration and Treatments
- Microbial Inactivation Methods
- Arsenic contamination and mitigation
- Spinal Fractures and Fixation Techniques
- Ocular Oncology and Treatments
- interferon and immune responses
- Acne and Rosacea Treatments and Effects
- Diabetes Treatment and Management
- Sphingolipid Metabolism and Signaling
- dental development and anomalies
- Proteoglycans and glycosaminoglycans research
- Gout, Hyperuricemia, Uric Acid
- Korean Urban and Social Studies
- Adenosine and Purinergic Signaling
- Spinal Cord Injury Research
- Listeria monocytogenes in Food Safety
Ningxia Medical University
2022-2025
Sichuan University
2011-2023
ORCID
2022
Air Force Medical University
2010-2021
Xijing Hospital
2009-2021
State Key Laboratory of Oral Diseases
2014-2020
Chengdu University
2020
Xi'an Jiaotong University
2020
National Institute of Allergy and Infectious Diseases
2020
National Institutes of Health
2020
The transcription factor hypoxia-inducible (HIF)-1 plays a central physiological role in oxygen and energy homeostasis is activated during hypoxia by stabilization of the subunit HIF-1alpha. Hypoxia an important development choroidal neovascularization (CNV). Expression HIF-1alpha has been demonstrated CNV. Vascular endothelial growth (VEGF) one most well-characterized angiogenic factors CNV, which under regulation HIF-1. aim present study was to explore upstream signaling pathways involved...
The cytosolic pattern recognition receptor NLRP3 senses host-derived danger signals and certain microbe-derived products in both humans rodents. activation assembles an inflammasome complex that contains the adapter proteins ASC caspase-1, whose triggers maturation release of proinflammatory cytokines IL-1β IL-18. S5 phosphorylation prevents its oligomerization activation, whereas dephosphorylation this residue by phosphatase PP2A allows activation. However, protein kinase mediates is...
Although surgery offers the only hope of cure for hepatocellular carcinoma (HCC), patients with inoperable or metastatic disease have a dismal prognosis. Therefore, there is an urgent need new and effective treatment strategies. Polymeric micelles composed drug conjugated to diblock copolymer attracted great interest clinical administration anticancer drugs. In this work, characteristics cytotoxicity doxorubicin-poly(d,l-lactic-co-glycolic acid)-poly(ethylene glycol) (DOX-PLGA-PEG) micelle...
<title>Abstract</title> Background Inhibition of hypoxia-induced apoptosis in cardiomyocytes is crucial for heart failure treatment. Previous research suggests that nuclear respiratory factor-1 (NRF-1) protects hypoxic against apoptosis. In the present study, we hypothesized NRF-1 regulates expression Caspase 8 and FADD-like regulator (CFLAR) thus contributes to regulation cardiomyocytes. Methods Results Chromatin immunoprecipitation (ChIP) Dual-Glo luciferase assays confirmed binds...
Arsenic, an important hazard in the environment, is associated with human cancer and other degenerative diseases. However, mechanisms underlying arsenic hazardous effects remain unclear. It has been reported exposure can result increased cellular reactive oxygen species oxidative DNA damage. This suggests base excision repair (BER), major pathway for repairing damage, may be involved combating effects. As a critical enzyme BER, polymerase beta (Pol β) might play essential role reducing...
Pulsed electric fields (PEF) induced cellular damage in Saccharomyces cerevisiae, mainly focusing on metabolic properties including performance of mitochondria and enzymes, was evaluated this study. The proportion sublethally injured S. cerevisiae cells around 90% after PEF treatment at 20 kV/cm for 100–500 μs. Sublethal injure correlated with to membranes caused by PEF, which also confirmed the glucose-energized repair process. An increase plasma membrane Ca2+-ATPase, decrease cytoplasmic...
Abstract Spinal cord injury (SCI) is frequently accompanied by a degree of spontaneous functional recovery. The underlying mechanisms through which such recovery generated remain elusive. In this study, we observed significant motor function 14 to 28 days after spinal transection (SCT) in rats. Using comparative proteomics approach, caudal the injury, detected difference 20 proteins. Two these proteins, are eukaryotic translation initiation factor 5A1 (eIF5A1) that involved cell survival and...
Abstract Background Mechanical loading is known to play an important role in bone remodeling. Purpose This study aimed evaluate the effect of direct low‐magnitude high‐frequency ( LMHF ) microvibration on dental implant formation and osseointegration. Materials Methods Titanium implants were installed rabbit tibiae. The left legs loaded with mechanical vibration (15 μm at 10, 20, 30, 40 Hz (10, groups, respectively) for 30 minutes every day. right used as a sham control did not receive load....
Abstract Transcriptional coactivator with PDZ‐binding motif (TAZ), a Hippo pathway downstream effector, promotes tumor progression by serving as transcriptional TEAD. Here, we introduced new construct which can express the TEAD‐binding domain of TAZ protein (TAZBD), and determined its antitumor effect in malignant glioma both vitro vivo. We first observed that was upregulated tissues related to clinicopathologic characteristic, indicating crucial role during progression. In U87 U251 cells,...
Certain mechanical stimuli-particularly low-magnitude, high-frequency vibration-could induce bone marrow stem cell osteogenic differentiation and promote formation via Wnt signaling pathway, although the molecular mechanism is still unclear. In this study, we found that miR-335-5p significantly upregulated after vibration, which suppresses expression of inhibitor Dickkopf-related protein 1. Inhibition greatly reduced differentiation. Furthermore, increase level was also confirmed in vivo...
Using the commercially available antidiabetic drug exenatide (exendin-4) as a model peptide, we designed novel derivative, termed LEX-1, comprising 12-mer albumin-binding protease-sensitive linker and native exenatide. In addition, site-specific PEGylation was performed using LEX-1 lead sequence to generate four derivatives (LEX-2 LEX-5). Moreover, determined optimal molecular weight of maleimide-derivatized PEG for by an
Abstract Hypoxia is a primary inducer of cardiomyocyte injury, its significant marker being hypoxia-induced apoptosis. Nuclear respiratory factor-1 (NRF-1) and hypoxia-inducible factor (HIF)-1α are transcriptional regulatory elements implicated in multiple biological functions, including oxidative stress response. However, their roles apoptosis remain unknown. The effect HIF-α, together with NRF-1, exerts on also remains unclear. We established myocardial hypoxia model investigated the...
The evaluation of the park vitality and research their factors mechanisms are practical significance for optimizing planning design guidelines parks. Using new urban data from mobile positioning logs, website reviews, points interest (POIs), this study measures in Chengdu, China three dimensions spatial aggregation, temporal stability, subjective perception. 23 variables built environment parks were selected. geographical detector, main each dimension investigated. found that: (1) There...