A5025597110- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hepatitis B Virus Studies
- Pediatric health and respiratory diseases
- RNA modifications and cancer
- Magnesium in Health and Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- High-Temperature Coating Behaviors
- Menstrual Health and Disorders
- Hepatitis C virus research
- interferon and immune responses
- High Temperature Alloys and Creep
- HIV/AIDS drug development and treatment
- Advanced Materials Characterization Techniques
- Ubiquitin and proteasome pathways
- Respiratory Support and Mechanisms
- Clinical Laboratory Practices and Quality Control
- Viral gastroenteritis research and epidemiology
- Cell Adhesion Molecules Research
- Chronic Kidney Disease and Diabetes
- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- Circular RNAs in diseases
First Hospital of Jilin University
2017-2024
Jilin University
2013-2024
University of Science and Technology Beijing
2022
The effect of magnesium (Mg) deficiency on the prevalence diabetes and diabetic complications has received a great attention. present study investigated association Mg level in serum or urine patients, lived Northeast areas China, with either pre-diabetes without complications. From January 2010 to October 2011, patients type 1 (T1D, n = 25), 2 (T2D, 137), impaired fasting glucose (IFG, 12) tolerance (IGT, 15), age/gender matched control (n 50) were enrolled First Hospital Jilin University....
Numerous differentially expressed long non-coding RNAs (lncRNAs) have been identified in cerebral ischemia-reperfusion (I/R) injury using RNA-Seq analysis. However, little is known about whether and how lncRNAs are involved I/R injury. In this study, we investigated the function of lncRNA Oprm1 explored underlying mechanism. An oxygen-glucose deprivation model N2a cells was utilized to mimic vitro. Trypan blue staining, terminal deoxytransferase-mediated dUTP-biotin nick end labelling...
The development and growth of children influence values liver function tests. This study aims to establish age- gender-specific pediatric reference intervals among Han in Changchun, China. A total 1394 healthy children, aged 2–14 years, were recruited from communities schools with informed parental consent Changchun. levels serum alanine aminotransferase (ALT), aspartate (AST), γ-glutamyltransferase (GGT), alkaline phosphatase (ALP), protein (TP), albumin (ALB), bilirubin (TBIL) direct...
Tripartite motif 44 (TRIM44), a member of the TRIM protein family, has been shown to play role in tumor development and progression. However, potential involvement TRIM44 prostate cancer not fully explored. Therefore, present study, we analyzed expression assessed progression cancer. Our results showed that was significantly upregulated human cell lines. In addition, knockdown inhibited proliferation, migration, invasion cells vitro, as well attenuated growth vivo. Mechanistic studies...
Objective: This study aimed to explore specific biochemical indicators and construct a risk prediction model for diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D). Methods: included 234 T2D patients, of whom 166 had DKD, at the First Hospital Jilin University from January 2021 July 2022. Clinical characteristics, such as age, gender, typical hematological parameters, were collected used modeling. Five machine learning algorithms [Extreme Gradient Boosting (XGBoost),...
BACKGROUND Chronic obstructive pulmonary disease (COPD) is a type of lung characterized by long-term breathing problems and poor airflow. COPD can progress to persistent decline function. This study explored the effect CXCL10 on induced cigarette smoke (CS) its underlying mechanism. MATERIAL AND METHODS Wild-type (WT) mice were randomly assigned into 3 groups: control group, CS intervention group. Mice in group exposed neutralizing antibody. At 24 h after last exposure, body weight functions...
GST-HG131, a novel dihydroquinolizinone (DHQ) compound, has been shown to reduce circulating levels of HBsAg in animals. This first-in-human trial evaluated the safety, tolerability, and pharmacokinetic profile GST-HG131 healthy Chinese subjects.
Alloys meeting the requirements of “700 °C and above” advanced ultra-super-critical technology, with higher thermal efficiency, have been developed in recent years. Here, a new wrought Ni-based superalloy excellent high-temperature creep strength based on Waspaloy has is proposed as candidate material for application 700 class steam turbine blades. In this alloy, Molybdenum (Mo) partially replaced by Tungsten (W). Creep tests shown that alloy 70 MPa creep-rupture than at extrapolating...
Abstract Background Our study aimed to investigate signature RNAs and their potential roles in type 1 diabetes mellitus (T1DM) using a competing endogenous RNA regulatory network analysis. Methods Expression profiles of GSE55100, deposited from peripheral blood mononuclear cells 12 T1DM patients 10 normal controls, were downloaded the Gene Omnibus uncover differentially expressed long non-coding (lncRNAs), mRNAs, microRNAs (miRNAs). The ceRNA was constructed, then functional pathway...