In this study, C57BL/6J mice were fed diets supplemented with different proportions of lactulose (0%, 5%, and 15%) for 2 weeks to study its effects on the luminal mucosal microbiota. The samples cecum colon investigated. After high-lactulose treatment (15%), pH contents decreased from 6.90-7.72 5.95-6.21 distal colon, amount total short-chain fatty acids in was significantly increased. content mostly dominated by Firmicutes, Actinobacteria, Bacteroidetes, while mucus Proteobacteria,...

Constipation is one of the most common gastrointestinal complaints worldwide. The aim this study was to determine whether edible bifidobacteria (Bifidobacterium longum, B. infantis, animalis, bifidum, adolescentis or breve) exhibit interspecies differences in alleviating constipation induced by loperamide BALB/c mice and analyse main reasons for differences. were given gavage once per day 8 days. primary outcome measures, which included related indicators, secondary changes concentration...

Fructooligosaccharides (FOS) are a well-known class of prebiotic and considered to selectively stimulate the growth bifidobacteria in gut. Previous studies focused on stimulation Bifidobacterium, but they did not further investigate bifidobacterial composition specific species that were stimulated. In this study, mice fed with FOS different doses for four weeks fecal microbiota, particular was analyzed by sequencing V3⁻V4 region groEL gene MiSeq platform, respectively. high-dose group,...

Gut microbiome plays an essential role in asthma development, and probiotic-based manipulation of the gut has been proposed to prevent asthma. Although preventive effect Lactobacillus supplementation against allergies reported, precise species beneficial for effective prevention remain unidentified underlying mechanisms unclear. Therefore, we aimed investigate efficacy oral administration six mechanism via modulation. We investigated effects L. rhamnosus, fermentum, casei, gasseri,...

Transglutaminase (TGase) was added to soy protein isolate (SPI) dispersion after the combination treatment of high intensity ultrasound (HIU) and hydrostatic pressure (HHP) catalyze formation cold gel, which used encapsulate riboflavin. The structure, physicochemical properties in vitro digestion characteristics riboflavin-loaded SPI gel were investigated. HIU-HHP combined enhanced strength, water retention, elastic property, thermal stability denaturation degree gels, improved network...

Glioblastoma (GBM) is a highly malignant, invasive, and poorly prognosed brain tumor. Unfortunately, active comprehensive treatment does not significantly prolong patient survival. With the deepening of research, it has been found that gut microbiota plays certain role in GBM, can directly or indirectly affect efficacy immune checkpoint inhibitors (ICIs) various ways. (1) The metabolites produced by host’s homeostasis, these function distribution cells, promote inhibit inflammatory...

The sheep intestinal tract is characterized by a diverse microbial ecosystem that vital for the host to digest diet material. importance of gut microbiota (GM) animals has also been widely acknowledged because its pivotal roles in health and well-being animals. However, there are no relevant studies on GM small-tail Han sheep, superior mutton variety domestic China. In this study, structure distribution microflora were studied high-throughput sequencing technology. Results showed significant...

Abstract The aim of this study was to compare the physicochemical properties chitosan prepared by microwave and water bath heating with an equivalent quantity heat intake. structure obtained these two methods were characterized Fourier transform infrared spectroscopy (FTIR), X‐ray diffractometry (XRD), gel permeation chromatography (GPC), scanning electron microscopy ( SEM ). FTIR XRD patterns show that there no significant difference in produced sources. results showed 73.86% deacetylation...

Acute pancreatitis (AP) is a common abdominal inflammatory disease. Disturbed gut homeostasis secondary to pancreatic inflammation aggravates the condition retroactively. The current study investigates potential beneficial effects of Clostridium butyricum (C. butyricum) strains on AP and underlying mechanisms.C. MIYAIRI 588 (CBM588) CGMCC0313.1 (CB0313.1) were supplemented mice for three weeks before experimental or SAP induction. Both CBM588 CB0313.1 protected against AP, as evidenced by...

The health-associated benefits of bifidobacteria has generated interest in the production bifidobacteria-fermented milk. In this study, three fermented milks were using Bifidobacterium longum subsp. YS108R which is a ropy-exopolysaccharide producer, probiotic strain animalis lactis BB12, and starter culture blend composed Lactobacillus delbrueckii bulgaricus Streptococcus thermophilus. proved as effective for reducing pH during milk fermentation. to decrease disease active index by 29%...

In this study, changes in the physical, structural, and assembly characteristics of silver carp myofibrillar proteins (MPs) at different ionic strength (I) values were investigated. Moreover, differential proteomic profile soluble MPs was analyzed using 4D proteomics based on timsTOF Pro mass spectrometry. Solubility significantly increased high I (>0.3), increase enhanced apparent viscosity, fluorescence intensity, surface hydrophobicity, α-helix content solution. Particle size sodium...

The present study aims to evaluate the adverse events associated with Capmatinib using real-world data, providing a reference basis for its rational use in clinical practice. Relevant data from Food and Drug Administration event reporting system database was mined. Next, odds ratio Bayesian confidence propagation neural network method were used analyze Capmatinib. revealed significant signals of Capmatinib, primarily involving general disorders administration site conditions, cardiac...

Background Post-marketing regulatory data suggest a potential association between atorvastatin use and memory protection; however, findings from observational studies have been inconsistent remain subject of controversy. Objective This study aims to investigate the correlation exposure subjective deficits, with objective providing more precise safety efficacy information for its clinical use. Methods We utilized two primary sources: National Health Nutrition Examination Survey (NHANES)...

To investigate the effects of microwaves on quality oils, 33 different rapeseed oil samples were treated with microwave heating (MH) and conventional (CH) at same curve. The oxidation indices showed that, compared to CH, exhibited varying degrees under MH, which could be divided into three categories. Analysis bioactive components oils indicated strong negative correlations between degree polyphenol, tocopherol, phytosterol, squalene contents. Moreover, positively correlated unsaturation...