A5062668646- Cancer-related molecular mechanisms research
- Pelvic floor disorders treatments
- RNA modifications and cancer
- Anorectal Disease Treatments and Outcomes
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Functional Brain Connectivity Studies
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Advanced Proteomics Techniques and Applications
- Gastrointestinal motility and disorders
- Metabolomics and Mass Spectrometry Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Pesticide Residue Analysis and Safety
- Migraine and Headache Studies
- Traumatic Brain Injury Research
- Head and Neck Surgical Oncology
- Renal cell carcinoma treatment
- Chemokine receptors and signaling
- Ferroptosis and cancer prognosis
- Analytical Chemistry and Chromatography
- Nitric Oxide and Endothelin Effects
Hangzhou Medical College
2023-2025
Zhejiang Provincial People's Hospital
2023-2025
Chengdu Medical College
2025
Drug Safety Research Unit
2025
Weatherford College
2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Nantong University
2008-2024
China Construction Eighth Engineering Division (China)
2024
Nanjing University of Chinese Medicine
2021-2024
Abstract Accumulating evidence indicates that metabolic reprogramming of cancer cells supports the energy and demands during tumor metastasis. However, alterations underlying lymph node metastasis (LNM) cervical (CCa) have not been well recognized. In present study, it is found lymphatic metastatic CCa reduced dependency on glucose glycolysis but increased fatty acid oxidation (FAO). Inhibition carnitine palmitoyl transferase 1A (CPT1A) significantly compromises palmitate‐induced cell...
In this study, the chemical constituents of pu-erh tea, black and green as well those tea products different ages, were analyzed compared using a profiling approach. Differences in processing resulted differences color infusions. Human biological responses to ingestion also studied by ultraperformance liquid chromatography−quadrupole time-of-flight mass spectrometry (UPLC−QTOFMS) conjunction with multivariate statistical techniques. Metabolic alterations during after characterized increased...
Whole-organ decellularization has been identified as a promising choice for tissue engineering. The aim of the present study was to engineer intact whole rat liver scaffolds and repopulate them with hepatocytes endothelial progenitor cells (EPCs) in bioreactor. Decellularized were obtained by perfusing Triton X-100 ammonium hydroxide. architecture composition original extracellular matrix preserved, confirmed morphologic, histological, immunolabeling methods. To determine biocompatibility,...
Abstract Circular RNAs (circRNAs) are known to act as key regulators in a variety of malignancies. However, the role circRNAs cervical cancer (CCa) remains largely unknown. Herein, we demonstrated that circRNA derived from TADA2A gene (hsa_circ_0043280) was significantly downregulated CCa and this reduction expression correlated with poor prognosis. Furthermore, our results hsa_circ_0043280 functions tumor suppressor inhibit growth metastasis CCa. Mechanistically, competitively sponges...
Abstract Epithelial-mesenchymal transition (EMT) is an essential step to drive the metastatic cascade lymph nodes (LNs) in cervical cancer cells. However, few of them metastasize successfully partially due increased susceptibility immunosurveillance conferred by EMT. The precise mechanisms cells orchestrate EMT and immune evasion remain largely unexplored. In this study, we identified a lncRNA termed node metastasis associated suppressor (LNMAS), which was downregulated LN-positive patients...
Abstract Aim Laryngeal cancer is a common malignancy; surgery the preferred treatment. Psychosocial stress one of negative impacts on patient recovery. This study aimed to elucidate effect probiotics ameliorating anxiety, and serum corticotropin‐releasing factor ( CRF ) in laryngeal patients before surgery. Methods A total 30 with 20 healthy volunteers were recruited. During 2 weeks surgery, randomly allocated receive or placebo twice day. Heart rate was recorded daily. The degree anxiety...
Magnetic resonance imaging (MRI) is by nature a multi-modality technique that provides complementary information about different aspects of diseases. So far no attempts have been reported to assess the potential multi-modal MRI in discriminating individuals with and without migraine, so this study, we proposed classification approach examine whether or not integration multiple features could improve performance between migraine patients aura (MWoA) healthy controls. Twenty-one MWoA 28...
Most migraineurs develop cutaneous allodynia (CA) during migraine, and the underlying mechanism of CA in migraine is thought to be sensitization third-order trigeminovascular neurons posterior thalamic nuclei. This study aimed investigate whether ascending/descending pathway associated with thalamus disturbed (MWCA) using effective connectivity analysis resting-state functional magnetic resonance imaging. Thirty four without aura (14 MWCA 20 (MWoCA)) 25 matched healthy controls (HC) were...
We used graph theoretical measures to investigate the hypothesis that structural brain connectivity constrains influence of functional on relation between age and fluid cognition. Across 143 healthy, community-dwelling adults 19-79 years age, we estimated network properties from diffusion-weighted imaging resting-state magnetic resonance imaging. confirmed previous reports age-related decline in strength efficiency networks, as well within modules. Functional contrast, exhibited only system...
The present study aims to evaluate the adverse events associated with Capmatinib using real-world data, providing a reference basis for its rational use in clinical practice. Relevant data from Food and Drug Administration event reporting system database was mined. Next, odds ratio Bayesian confidence propagation neural network method were used analyze Capmatinib. revealed significant signals of Capmatinib, primarily involving general disorders administration site conditions, cardiac...
Sideroflexin (SFXN) family genes encode for a group of mitochondrial proteins involved in cellular processes such as iron homeostasis, amino acid metabolism, and energy production. Recent studies showed that they were aberrantly expressed certain human cancers. However, there is paucity information about their expression prostate cancer. In this study, we took comprehensive approach to investigate profiles benign tissue, prostate-derived cell lines, cancer tissues using multiple...
Background Post-marketing regulatory data suggest a potential association between atorvastatin use and memory protection; however, findings from observational studies have been inconsistent remain subject of controversy. Objective This study aims to investigate the correlation exposure subjective deficits, with objective providing more precise safety efficacy information for its clinical use. Methods We utilized two primary sources: National Health Nutrition Examination Survey (NHANES)...
To explore the association between angiopoietin-like protein 2 (Angptl2) and cyclophilin A (CyPA) with acute myocardial infarction (AMI) occurrence of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). single-center retrospective research was conducted. Clinical data from 146 AMI patients who underwent PCI at our hospital were analyzed designated as group. Additionally, 56 healthy individuals medical check-ups during same period enrolled Control Serum levels Angptl2...
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder. It can be difficult to discern the symptoms of PTSD and obtain an accurate diagnosis. Different magnetic resonance imaging (MRI) modalities focus on different aspects, which may provide complementary information for discrimination. However, none published studies assessed diagnostic potential multimodal MRI in identifying individuals with without PTSD. In current study, we investigated whether conveyed by scans...
Lymph node (LN) metastasis is one of the most malignant clinical features in patients with cervical cancer (CCa). Understanding mechanism lymph will provide treatment strategies for CCa. Circular RNAs (circRNA) play a critical role development human cancers. However, and circRNAs remain largely unknown. Here, it reported that loss expression circRNA circVPRBP was closely associated LN poor survival CCa patients. In vitro vivo assays showed overexpression notably inhibited lymphangiogenesis...
In psychopharmacology, treatment with psychotropic drugs is often suboptimal, mainly because of the high interindividual variability in pharmacokinetic properties. Therapeutic drug monitoring (TDM) can be a valuable tool for individual effects prescribed dosage patient, and it facilitates antipsychotic by increasing effectiveness safety reducing costs. The aim this study was to develop validate an ultrafast liquid chromatography (UFLC) method tandem mass spectrometric detection measurement...
This study aimed to investigate the dysfunctional ascending/descending pain pathways at thalamic level in patients with migraine without aura (MWoA) using effective connectivity analysis of resting-state functional MRI. Twenty MWoA and 25 matched healthy controls participated MRI scans. The directional interactions between posterior thalamus (PTH) other brain regions were investigated Granger causality choosing bilateral PTH as two individual seeds. Pearson's correlation was carried out...