A5071063065- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Extracellular vesicles in disease
- Cancer, Stress, Anesthesia, and Immune Response
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Protein Kinase Regulation and GTPase Signaling
- Ubiquitin and proteasome pathways
- Seaweed-derived Bioactive Compounds
- Cytokine Signaling Pathways and Interactions
- Sepsis Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Genomics, phytochemicals, and oxidative stress
- Metabolomics and Mass Spectrometry Studies
- Immune Cell Function and Interaction
- Thermal Regulation in Medicine
Sun Yat-sen University
2020-2023
Jiangmen Central Hospital
2021
Sun Yat-sen Memorial Hospital
2020
Immune checkpoint blockade (ICB) therapies such as PD-1 antibodies have produced significant clinical responses in treating a variety of human malignancies, yet only subset cancer patients benefit from therapy. To improve the ICB efficacy, combinations with additional therapeutics were under intensive investigation. Recently, special dietary compositions that can lower risk or inhibit progression drawn attention, although few reported to show synergistic effects therapies. Interestingly,...
Hepatocellular carcinoma (HCC) is frequently characterized by metabolic and immune remodeling in the tumor microenvironment. We previously discovered that liver-specific deletion of fructose-1, 6-bisphosphatase 1 (FBP1), a gluconeogenic enzyme ubiquitously suppressed HCC tissues, promotes liver tumorigenesis induces perturbations closely resembling human HCC. However, underlying mechanisms remain incompletely understood. Here, we reported FBP1-deficient livers exhibit diminished amounts...
Sepsis represents one of the most pressing problems in pediatrics, characterized by pathogenic bacteria invading blood, growing and multiplying blood circulation, ultimately causing severe infections. Most children with sepsis have a rapid disease onset frequently exhibit sudden high fever or first chills. Here we performed comprehensive metabolomic profiling plasma samples collected from pediatric patients to identify specific metabolic alterations associated these ( n = 84, designated as...