A5100433051- Acute Lymphoblastic Leukemia research
- Pregnancy and preeclampsia studies
- Asthma and respiratory diseases
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Computational Drug Discovery Methods
- Inhalation and Respiratory Drug Delivery
- Flavonoids in Medical Research
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Bioactive Compounds
- Folate and B Vitamins Research
- Microbial Metabolism and Applications
- Carcinogens and Genotoxicity Assessment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lipid Membrane Structure and Behavior
- Cytokine Signaling Pathways and Interactions
- Ocular Surface and Contact Lens
- Sexuality, Behavior, and Technology
- Plant-based Medicinal Research
- Spaceflight effects on biology
- Pregnancy and Medication Impact
- Neurological Disease Mechanisms and Treatments
- Viral Infections and Vectors
- Drug Transport and Resistance Mechanisms
- Pharmaceutical studies and practices
Tongji Hospital
2025
Huazhong University of Science and Technology
2025
Kunming Medical University
2015-2023
First Affiliated Hospital of Kunming Medical University
2015-2023
Shandong University of Technology
2021
Indiana University Bloomington
2013
Center for Drug Evaluation and Research
2012
Sir Run Run Shaw Hospital
2011
Zhejiang University
2011
Both in-house human genetic and literature data have converged on the identification of leukotriene 4 hydrolase (LTA4H) as a key target for treatment cardiovascular disease. We combined fragment-based crystallography screening with an iterative medicinal chemistry effort to optimize inhibitors LTA4H. Ligand efficiency was followed throughout our structure−activity studies. As applied within context LTA4H inhibitor design, team able design potent compound 20 (DG-051) (Kd = 26 nM) high aqueous...
Abstract Objective Gestational diabetes mellitus (GDM) is a serious complication in pregnancy. Despite controlling the plasma glucose levels with dietary intervention (GDM-D) or insulin therapy (GDM-I), children born of diabetic mothers suffer more long-term complications from childhood to early adulthood. Placental circulation and nutrient exchange play vital role fetal development. Additionally, placental endothelial function an indicator vascular health, plays important maintaining for...
In psychopharmacology, treatment with psychotropic drugs is often suboptimal, mainly because of the high interindividual variability in pharmacokinetic properties. Therapeutic drug monitoring (TDM) can be a valuable tool for individual effects prescribed dosage patient, and it facilitates antipsychotic by increasing effectiveness safety reducing costs. The aim this study was to develop validate an ultrafast liquid chromatography (UFLC) method tandem mass spectrometric detection measurement...
Cationic amphiphilic drugs and aminoglycoside antibiotics can induce phospholipidosis (PLD), an abnormal accumulation of phospholipids in lysosome-derived vesicles, preclinical studies. The incidence PLD patients its clinical relevance are difficult to assess without noninvasive biomarkers. Di-docosahexaenoyl bis(monoacylglycerol)phosphate (di-22:6-BMP) is a phospholipid that enriched lysosomal membranes proposed urinary biomarker drug-induced PLD. specificity di-22:6-BMP for was compared...
Purpose . In this report, we investigated the protective mechanism of scutellarin (SCU) in vitro and vivo which could be involved endothelial cGMP-dependent protein kinase (PKG), vasodilator stimulated phosphoprotein (VASP) pathway, vascular endothelium dysfunction (EtD). Method Human brain microvascular cells (HBMECs) with hypoxia reoxygenation (HR) treatment rats cerebral ischemia reperfusion (CIR) were applied. Protein mRNA expression PKG, VASP, p-VASP evaluated by Western blot RT-PCR...
The untranslated region (UTRs) of viral genome are important for replication and immune modulation. Japanese encephalitis virus (JEV) is the most significant cause epidemic worldwide. However, little known regarding characterization JEV UTRs. Here, systematic analyses UTRs JEVs isolated from a variety hosts worldwide spanning about 80 years were made. All cis -acting elements structures compared with other mosquito-borne Flaviviruses [ West Nile (WNV), Yellow fever (YFV), Zika (ZIKV), Dengue...
Objective To preliminarily understand the current status of medication safety management medical institutions in China. Methods Medication Safety Panel China Core Group International Network for Rational Use Drugs (INRUD) and Chinese Pharmacological Society Professional Committee Drug-induced Diseases jointly established a research group. Basing on voluntary principle, members (medical institutions) group did self-assessment using questionnaires 2011 ISMP Medication Self Assessment®...
Objective To understand the adverse reactions of Kanglaite injection and its incidence explore factors affecting safety Injection in clinical use. Methods A non-interventional prospective hospital based monitoring study nested case-control were conducted. All hospitalized cancer patients receiving injections from 28 hospitals northeast, north, central, east, south, southwest, northwest regions China September 2013 to 2014 enrolled this study. The main contents included general status...
Abstract Objective Gestational diabetes mellitus (GDM) is a serious pregnancy complication. Even if the plasma glucose levels were controlled with dietary intervention (GDM-D) or insulin therapy (GDM-I), children from mothers have increased rates of CVD childhood to early adulthood. Endothelial function barometer vascular health. The study was conducted find out changes in fetal endothelial dysfunction GDM under different interventions pregnancies. primary HUVECs separated human normal...