A5100340691- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Pregnancy and preeclampsia studies
- Nitric Oxide and Endothelin Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Gestational Diabetes Research and Management
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Birth, Development, and Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Mechanisms and Therapy
- Dermatologic Treatments and Research
- Protein Tyrosine Phosphatases
- Bioinformatics and Genomic Networks
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Pregnancy and Medication Impact
- Drug Transport and Resistance Mechanisms
- Cytokine Signaling Pathways and Interactions
- Telomeres, Telomerase, and Senescence
- MicroRNA in disease regulation
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
JiangSu Armed Police General Hospital
2025
Chinese People's Armed Police Force
2025
Kunming Medical University
2018-2024
First Affiliated Hospital of Kunming Medical University
2018-2024
Harbin Medical University
2011-2022
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
Sichuan University
2022
Universidade Católica Portuguesa
2021
Shanxi Medical University
2018
We have found that 15-hydroxyeicosatetraenoic acid (15-HETE) induced by hypoxia was an important mediator in the regulation of hypoxic pulmonary hypertension, including vasoconstriction and remodeling. However, underlying mechanisms remodeling 15-HETE are poorly understood. In this study, we performed immunohistochemistry, artery endothelial cells migration tube formation, smooth muscle bromodeoxyuridine incorporation, cell cycle analysis to determine role hypoxia-induced vascular medial...
On a global scale, lung cancer(LC) is the most commonly occurring form of cancer. Nonetheless, process screening and detecting it in its early stages presents significant challenges. Earlier research endeavors have recognized metabolites as potentially reliable biomarkers for LC. However, majority these studies been limited scope, featuring inconsistencies terms relationships levels association observed.Moreover, there has lack consistency types biological samples utilized previous studies....
Pulmonary fibrosis (PF) is a severe lung disease that manifests as tissue destruction and collagen deposition easily leads to respiratory failure. It difficult reverse these conditions using current treatment methods. This study focused on the exploration development of novel drugs for PF. simulated pathological process PF by bleomycin (BLM)-induced rat model TGF-β1-induced in vitro cell model. Dian sanguis draconis (DSD) was used intervention, effects structure, fiber deposition, autophagy...
Abstract Objective Gestational diabetes mellitus (GDM) is a serious complication in pregnancy. Despite controlling the plasma glucose levels with dietary intervention (GDM-D) or insulin therapy (GDM-I), children born of diabetic mothers suffer more long-term complications from childhood to early adulthood. Placental circulation and nutrient exchange play vital role fetal development. Additionally, placental endothelial function an indicator vascular health, plays important maintaining for...
Reactive oxygen species (ROS) are involved in the pathologic process of pulmonary arterial hypertension as either mediators or inducers. Rutin is a type flavonoid which exhibits significant scavenging properties on radicals both vitro and vivo. In this study, we proposed that rutin attenuated hypoxia-induced artery smooth muscle cell (PASMC) proliferation by ROS. Immunofluorescence data showed decreased production ROS, was mainly generated through mitochondria NADPH oxidase 4 (Nox4)...
We previously reported that 15-lipoxygenase (15-LO) and its metabolite 15-hydroxyeicosatetraenoic acid (15-HETE) were up-regulated in pulmonary arterial cells from both artery hypertension patients hypoxic rats these factors mediated the progression of (PH) by affecting proliferation apoptosis (PA) cells. However, underlying mechanisms remodeling induced 15-HETE have remained unclear. As reactive oxygen species (ROS) 15-LO are hypoxia, it is possible ROS involved events hypoxia-induced...
Background: We have previously shown that 15-hydroxyeicosatetraenoic acid (15-HETE) plays a critical role in pulmonary hypertension (PH)-associated vascular remodeling. However, the signaling mechanisms remain unclear. The purpose of this study was to investigate 15-lipoxygenase-2 (15-LO-2)/15-HETE-mitogen-activated protein kinases (MAPKs) pathway hypoxia-induced remodeling and underlying mechanisms. Methods: arterial wall thickness measured by hematoxylin eosin (HE) staining distal arteries...
<abstract> <sec><title>Background</title><p>The deregulated genetic factors are critically associated with idiopathic pulmonary arterial hypertension (IPAH) development and progression. However, the identification of hub-transcription (TFs) miRNA-hub-TFs co-regulatory network-mediated pathogenesis in IPAH remains lacking.</p> </sec> <sec><title>Methods</title><p>We used GSE48149, GSE113439, GSE117261, GSE33463, GSE67597 for...
Pulmonary arterial hypertension (PAH) is a rapidly progressing cardiopulmonary disease. It characterized by increased pulmonary artery pressure and vascular resistance. The most notable histopathological characteristic remodeling. changes in the basement membrane (BM) are believed to be related crucial identify potential biomarkers associated with BM PAH, guide its treatment. microarray datasets GSE117261 GSE113439 were downloaded from Gene Expression Omnibus. Two data sets examined genes...
Objective To explore the effect of age factor on degree pulmonary fibrosis and change in telomerase reverse transcriptase(TERT)activity mice. Methods A total 80 healthy male C57BL/6 mice aged 20-weeks were randomized into 4 groups: a young model group(n=20), control senile an elderly group(n=20). Two groups induced by intratracheally injected bleomycin 5 mg/kg, two normal saline.The defined as 26 weeks old mice.Five mouse models five controls four randomly selected killed at 7, 14,...
Abstract Objective Gestational diabetes mellitus (GDM) is a serious pregnancy complication. Even if the plasma glucose levels were controlled with dietary intervention (GDM-D) or insulin therapy (GDM-I), children from mothers have increased rates of CVD childhood to early adulthood. Endothelial function barometer vascular health. The study was conducted find out changes in fetal endothelial dysfunction GDM under different interventions pregnancies. primary HUVECs separated human normal...