A5074373325- Pulmonary Hypertension Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Eicosanoids and Hypertension Pharmacology
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Liver Disease and Transplantation
- Protein Tyrosine Phosphatases
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
Xinjiang Medical University
2016-2022
First Affiliated Hospital of Xinjiang Medical University
2016-2022
Endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of various pulmonary diseases via activation unfolded protein response. However, role ER arterial hypertension (PAH) remains unclear. The well-known chemical chaperone 4-phenylbutyric acid (4-PBA) inhibits signaling. We hypothesized that known chaperones, including 4-PBA, would inhibit and prevent and/or reverse PAH.
Pulmonary arterial hypertension (PAH) is a severe and progressive disease that affects the heart lungs global health concern impacts individuals society. Studies have reported some proteins related to mitochondrial metabolic functions could play an essential role in pathogenesis of PAH, their specific expression biological function are still unclear. We successfully constructed monocrotaline- (MCT-) induced PAH rat model present research. Then, label-free quantification proteomic technique...
<abstract> <sec><title>Background</title><p>The deregulated genetic factors are critically associated with idiopathic pulmonary arterial hypertension (IPAH) development and progression. However, the identification of hub-transcription (TFs) miRNA-hub-TFs co-regulatory network-mediated pathogenesis in IPAH remains lacking.</p> </sec> <sec><title>Methods</title><p>We used GSE48149, GSE113439, GSE117261, GSE33463, GSE67597 for...