A5101558217- Gut microbiota and health
- Antimicrobial Peptides and Activities
- Probiotics and Fermented Foods
- Pancreatitis Pathology and Treatment
- Receptor Mechanisms and Signaling
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Paraquat toxicity studies and treatments
- Inflammatory Bowel Disease
- Moringa oleifera research and applications
- Immune Response and Inflammation
- Meat and Animal Product Quality
- Pharmacy and Medical Practices
- Ginseng Biological Effects and Applications
- Diabetes and associated disorders
- Neuropeptides and Animal Physiology
- Traditional Chinese Medicine Analysis
- Intensive Care Unit Cognitive Disorders
- Phytochemistry and Biological Activities
- Medicinal Plants and Neuroprotection
- Dermatology and Skin Diseases
- Gastrointestinal motility and disorders
- Renin-Angiotensin System Studies
- Essential Oils and Antimicrobial Activity
- Anesthesia and Neurotoxicity Research
Hainan University
2021-2024
WuXi AppTec (China)
2024
Nanjing Drum Tower Hospital
2019-2021
State Key Laboratory of Food Science and Technology
2019
Jiangnan University
2019
Baotou Medical College
2018
Shandong First Medical University
2013
Jinan City People's Hospital
2013
Acute pancreatitis (AP) is a common abdominal inflammatory disease. Disturbed gut homeostasis secondary to pancreatic inflammation aggravates the condition retroactively. The current study investigates potential beneficial effects of Clostridium butyricum (C. butyricum) strains on AP and underlying mechanisms.C. MIYAIRI 588 (CBM588) CGMCC0313.1 (CB0313.1) were supplemented mice for three weeks before experimental or SAP induction. Both CBM588 CB0313.1 protected against AP, as evidenced by...
Vitamin D 3 , as an indispensable and fat‐soluble micronutrient, plays important role in the health of humans animals. At present, studies are focusing on calcium absorption immunoregulation function vitamin ; this study was aimed at exploring antioxidative stress ability diquat‐induced intestinal dysfunction ICR mice underlying mechanism. The results showed that oral gavage daily significantly improved body weight gain immune organ index reverted abnormal changes ALT, AST, SOD, GSH‐Px,...
Vitamin D3 (VD3) is an indispensable micronutrient in livestock and poultry feed. Its function antioxidant stress has been reported. We investigate whether the addition of different concentrations VD3 to diet affects production performance, slaughter meat quality, organ index, gut injury on diquat (DQ)-induced model oxidative Wenchang chickens. Four hundred eighty one-day-old chickens were randomly divided into six groups: control (basal diet), 4000 VD + IU per kg feed intake), 1000 VD+DI...
This study was conducted to investigate the beneficial effect of purple sweet potato anthocyanins (PSPA) on growth performance, oxidative status, immune response, intestinal morphology, and flora homeostasis in heat-stressed Wenchang chickens. A total 100 chickens (50-day-old) were randomly assigned 5 groups, including thermoneutral environment (TN) group (26°C); high-temperature stressed (HS) (33°C ± 1°C); low-dose PSPA treatment (L_HS) (8 mg/kg body weight, 33°C medium-dose (M_HS)...
General anesthetics can induce cognitive impairments and increase the risk of Alzheimer’s disease (AD). However, underlying mechanisms are still unknown. Our previous studies shown that long-term isoflurane exposure induced peripheral central insulin resistance (IR) in adult mice aggravated IR type 2 diabetes mellitus (T2DM) mice. Clinical preclinical revealed an association between impaired signaling tau pathology AD other tauopathies. We investigated if alleviation hippocampal by...
Introduction Angiotensin receptor-neprilysin inhibitor (ARNi), comprised of an angiotensin receptor blocker (ARB) and a neprilysin (NEPi), has established itself as safe effective intervention for hypertension. S086 is novel ARNi cocrystal developed by Salubris the treatment heart failure Methods Dahl Salt Sensitive (DSS) hypertensive rat model telemetry system were employed in this study to investigate anti-hypertensive efficacy compare it with first ARNi-LCZ696. Results discussion The...
Scope This study aims to examine the protective effects of specific low‐methoxyl pectin (LMP) on development type 1 diabetes (T1D). Methods and results Female non‐obese diabetic (NOD) mice are weaned onto either control or 5% LMP supplemented diets for up 22 weeks age. T1D incidence, gut barrier function, pancreatic‐gut immune responses analyzed. supplementation significantly dampened onset in NOD mice. induces caecal homeostasis, as indicated by increasing SCFAs production, higher...
Ulcerative colitis (UC) is a kind of inflammatory bowel disease (IBD) that often recurs and difficult to cure, no drugs with few side effects are available treat this disease. LfcinB small molecular peptide obtained by the hydrolysis bovine lactoferrin in digestive tract animals. It has strong antibacterial anti-inflammatory activities. However, direct evidence improves condition mice rarely reported. In study, UC was induced adding 2.5% dextran sulfate (DSS) drinking water orally...
Phenylethanoid glycosides (PHG), derived from Herba cistanche, were found to exert protective effects on cognitive dysfunctions by improving synaptic plasticity in Alzheimer's disease (AD) rat model. However, the mechanisms underlying these of PHG remain be determined. Thus aim this study was examine influence male AD model induced bilateral central nervous system ventricle injections beta amyloid 1–42 oligomers (Aβ1–42). The following parameters measured: (1) number intact pyramidal cells...
Abstract Objective The purpose of this study was to determine the effect Abaecin on dextran sulfate sodium (DSS) -induced ulcerative colitis in mice and explore its related mechanisms. Methods Twenty-four with similar body weight were randomly divided into 4 groups. 2.5% DSS added drinking water induce mice. Mice executed after administration treatment, mouse serum tissues collected. We measured concentration inflammatory cytokines produced colon tissue sections observe damage colonic...