A5031674873- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Cytomegalovirus and herpesvirus research
- Chemokine receptors and signaling
- Magnolia and Illicium research
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Pancreatitis Pathology and Treatment
- Phagocytosis and Immune Regulation
- Circular RNAs in diseases
- Macrophage Migration Inhibitory Factor
- Inflammatory mediators and NSAID effects
Sun Yat-sen University
2020-2025
Third Affiliated Hospital of Sun Yat-sen University
2020-2025
Hunan Normal University
2024
Hunan Provincial People's Hospital
2024
Dendritic cells are the most potent antigen-presenting in immune therapeutic approaches for chronic hepatitis B (CHB) infection. Here, we developed a clinical trial to evaluate efficacy and safety of autologous HBV vaccine-pulsed DCs their induced T (HPDCT) CHB patients. This was randomised, prospective, open-label, multicentre, superiority study 309 treatment-naive patients were divided into HPDCT plus nucleos(t)ide analogues (NAs) group (n = 84), NAs mono-therapy 82), Peg-interferon...
Hepatocellular carcinoma (HCC), which is prevalent worldwide and has a high mortality rate, needs to be effectively diagnosed. We aimed evaluate the significance of plasma microRNA-15a/16-1 (miR-15a/16) as biomarker hepatitis B virus-related HCC (HBV-HCC) using machine learning model. This study was first large-scale investigation these two miRNAs in samples. Using quantitative polymerase chain reaction, we measured miR-15a/16 levels total 766 participants, including 74 healthy controls, 335...
The lack of effective non-invasive diagnostic methods for liver fibrosis hinders timely treatment chronic hepatitis B (CHB) patients, leading to the progression advanced disease. Circulating microRNAs offer a approach assessment. MicroRNA-15a/16-1 (miR-15a/16) was reported be implicated in development, but role plasma miR-15a/16 assessment remains poorly understood. This study explored importance assessing severity CHB patients.
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is an inhibitory receptor that expressed on the surface of multiple immune cells and plays key roles in modulation. In patients with chronic hepatitis B (CHB), T cell number functions are abnormal expression receptors elevated. However, LAIR-1 CHB still undetermined.We recruited 320 different disease phases 17 healthy donors. Serum biochemical virological examinations were performed for each participant, their demographic clinical...
Abstract Background & Aims T‐cell receptor (TCR) repertoire is ambiguously changed in chronic hepatitis B (CHB) patients during antivirus therapy. We tried to assess TCR dynamics and its clinical significance upon HBeAg seroconversion CHB patients. Methods Twenty undergoing 1‐year entecavir (ETV) treatment were enrolled, including 10 complete response (CR) vs non‐complete (NCR) based on at week 48. The TCRβ complementarity‐determining region 3 (CDR3) of peripheral CD4 + CD8 T cells weeks...
<title>Abstract</title> <bold>Background: </bold>Chronic hepatitis B virus infection (CHB) is the serious health threaten with high morbidity and mortality.<bold> </bold>The work of innate adaptive immune systems determines development prognosis CHB. Immune checkpoints (ICs) play a crucial role in regulating response by providing inhibitory or stimulatory signals when interacting their ligands. However, precise mechanism which ICs affect outcome CHB patients remains unclear. <bold>Methods:...
Purpose C motif chemokine ligand 21 (CCL21) is important for tissue homeostasis, immune surveillance. However, the relationship between CCL21 expression, tumor immunity, and prognosis in human tumors remains unclear. Methods expression data were extracted from online databases, including The Cancer Genome Atlas (TCGA), Genotype Tissue Expression (GTEx) Cell Line Encyclopedia (CCLE). Tumor IMmune Estimation Resource (TIMER) database was used to study association infiltration checkpoint genes....
Abstract Hepatitis B virus (HBV) pregenomic RNA (pgRNA) is a new biomarker that reflects HBV replication, but its relationship with natural killer (NK) cell immunity in chronic hepatitis (CHB) unknown. We assessed serum pgRNA levels 323 CHB patients by reverse transcription-polymerase chain reaction, cytokine production and activation inhibitory markers of NK cells flow cytometry, measured cytokines enzyme-linked immunosorbent assays (ELISAs). Among the different phases, level was highest...
Yurong Gu, Ph.D., Yanhua Bi, B.S., Zexuan Huang, Chunhong Liao, Xiaoyan Li, Hao Hu, B.M., Huaping Xie, and Yuehua M.D., Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2024.0178
Background: Immune response mediated by T cells plays an important role in chronic hepatitis B (CHB). As immunoregulatory molecule, little is known about the characteristics of cell immunoglobulin and mucin-domain-containing molecule-3 (Tim-3) on cells. In this study, association Tim-3 its subset with clinical-virological features treatment-naïve CHB patients were identified. Methods: From July 2015 to January 2017, we carried-out a cross-sectional study which 320 different phases (immune...