A5100405266- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Diabetes Treatment and Management
- Drug Solubulity and Delivery Systems
- Wastewater Treatment and Nitrogen Removal
- Microbial Fuel Cells and Bioremediation
- Acupuncture Treatment Research Studies
- Global Health Care Issues
- Metabolism, Diabetes, and Cancer
- Edible Oils Quality and Analysis
- Retinal Imaging and Analysis
- Pregnancy and Medication Impact
- Inflammasome and immune disorders
- Meat and Animal Product Quality
- Healthcare professionals’ stress and burnout
- Multiple and Secondary Primary Cancers
- Health Systems, Economic Evaluations, Quality of Life
- Urban Green Space and Health
- Land Use and Ecosystem Services
- Andrographolide Research and Applications
- Medical Research and Treatments
- Analytical Chemistry and Chromatography
- Myofascial pain diagnosis and treatment
- Water Treatment and Disinfection
- Smart Grid and Power Systems
Peking University
2023-2024
Peking University Third Hospital
2023-2024
Yangzhou University
2024
Sichuan University
2024
Northeastern University
2024
West China Hospital of Sichuan University
2024
Heilongjiang University
2024
Shanghai Jiao Tong University
2024
University at Buffalo, State University of New York
2023
Altria (United States)
2023
The study analysed healthcare workers' (HCWs) knowledge, practices, and attitudes regarding coronavirus disease 2019 (COVID-19). A cross-sectional survey was conducted from February 4th to 8th, 2020, involving a total of 1357 HCWs across 10 hospitals in Henan, China. Of those surveyed, 89% had sufficient knowledge COVID-19, more than 85% feared self-infection with the virus, 89.7% followed correct practices COVID-19. In addition level, some risk factors including work experience job category...
This paper proposes an automated blood vessel detection scheme based on adaptive contrast enhancement, feature extraction, and tracing. Feature extraction of small vessels is performed by using the standard deviation Gabor filter responses. Tracing done via forward detection, bifurcation identification, backward verification. Tests over twenty images show that for normal images, true positive rate (TPR) ranges from 80% to 91%, their corresponding false rates (FPR) range 2.8% 5.5%. For...
Abstract HSK3486, a central nervous system inhibitor, has demonstrated superior anesthetic properties in comparison with propofol. Owing to the high liver extraction ratio of HSK3486 and limited susceptibility multi‐enzyme inducer, rifampicin, indicated population is substantial. Nevertheless, order expand indications, it crucial assess systemic exposure specific populations. Moreover, main metabolic enzyme UGT1A9, which shows gene polymorphism population. Thus, scientifically design dose...
Commonly used cleaning brushes in the reprocessing of flexible endoscopes often cause damage within working channels.
: Physiologically based pharmacokinetic (PBPK) absorption models are instrumental for assessing drug prior to clinical food effect studies, though discrepancies in predictive and actual outcomes observed. This study focused on immediate release formulations of weakly basic water-insoluble compounds, namely rivaroxaban, ticagrelor, PB-201, investigate factors that could improve the accuracy PBPK regarding effects.
Epithelial-mesenchymal transition (EMT) and cyclooxygenase-2 (COX-2) contribute to airway remodelling inflammation in chronic obstructive pulmonary disease (COPD). Recent data suggest that the farnesoid X receptor (FXR), a nuclear traditionally considered as bile acid-activated receptor, is also expressed non-classical acids target tissues with novel functions beyond regulating acid homeostasis. This study aimed investigate potential role of FXR development COPD, well factors affect...
The abundance of drug metabolic enzymes (DMEs) and transporters (DTs) in the human gastrointestinal tract significantly affects xenobiotic exposure circulating system, basis these compounds acting on humans. However, accurately predicting individual healthy subjects remains challenging due to limited data protein levels throughout within same individuals inadequate assessment factors influencing levels. Therefore, we conducted a clinical study obtain biopsy samples from 8 different segments...
Abstract PB‐201 is the second glucokinase activator in world to enter phase III clinical trials for treatment of type 2 diabetes mellitus (T2DM). Combined with efficacy advantages and friendly absorption, distribution, metabolism, excretion characteristics, indication population will be broad. Because liver primary organ elimination, elderly account 20% patients T2DM, it essential estimate exposure specific populations understand pharmacokinetic characteristics avoid hypoglycemia. Despite...
HSK7653, an oral dipeptidyl peptidase-4 inhibitor administered every 2 weeks, is a candidate for the treatment of type diabetes mellitus. The major elimination pathway HSK7653 in vivo renal excretion, and hepatic metabolism fecal excretion unchanged compound contribute less to systemic clearance HSK7653. Considering disposition characteristics potential indication population evaluating exposure patients with impairment geriatric populations prerequisite bringing more benefits patients. Here,...
HKS21542, a highly selective activator of peripheral kappa opioid receptor agonists, plays critical role in antinociception and itch inhibition during clinical development. Due to its indication population elimination characteristics, it is imperative evaluate the potential HSK21542 systemic exposure individuals with renal impairment, hepatic elderly, geriatric population. Here, physiologically-based pharmacokinetic (PBPK) model for was developed based on vitro metabolism transport...
In this study, Andrographis paniculata seedlings were used as experimental materials to study the effects of salicylic acid(SA) on growth and effective component accumulation A. under NaCl stress. The results showed that with increase concentration, was significantly inhibited, content carotene carotenoid decreased. activity antioxidant enzyme enhanced. At same time, contents proline, proline soluble protein rise. andrographolide, new andrographolide deoxyandrographolide an upward trend,...
Urbanization is one of the important factors leading to biodiversity loss and habitat fragmentation. As an component urban ecosystem, soil fauna community plays a key role in improving structure fertility, promoting material circulation ecosystem. To investigate distribution characteristics medium small-sized green space mechanisms underlying their responses environmental change during urbanization, we selected 27 plots with gradient urban, suburban, rural areas Nanchang City as study...