A5102742070- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Immune cells in cancer
- Immune Cell Function and Interaction
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Galectins and Cancer Biology
- Macrophage Migration Inhibitory Factor
- Blood groups and transfusion
- Inflammasome and immune disorders
- Signaling Pathways in Disease
- Radiomics and Machine Learning in Medical Imaging
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Pancreatic and Hepatic Oncology Research
- Reproductive System and Pregnancy
- Organ and Tissue Transplantation Research
- Organ Transplantation Techniques and Outcomes
- Erythropoietin and Anemia Treatment
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- interferon and immune responses
- Diabetes and associated disorders
- Peptidase Inhibition and Analysis
Huazhong University of Science and Technology
2009-2024
Tongji Hospital
2009-2024
University of California, San Diego
2000-2022
Abstract Chronic constriction of the sciatic nerve, leading to a hyperalgesic state, results in partial lesion wherein some axons are injured and others remain intact. Here we sought characterize reactive changes which occur DRG cell bodies uninjured projecting skin muscle. Using immunohistochemistry combined with flurorogold fluororuby retrograde labelling define associated axons, analysed immunoreactivity (IR) for tumour necrosis factor‐alpha (TNF), interleukin‐10 (IL‐10), sensory...
Various microbial products leaked from gut lumen exacerbate tissue inflammation and metabolic disorders in obesity. Vsig4+ macrophages are key players preventing infiltration of bacteria their into host tissues. However, roles islet the communication between microbiota β cells pathogenesis obesity-associated abnormalities unknown. Here, we find that bacterial DNAs enriched individuals with Intestinal DNA-containing extracellular vesicles (mEVs) readily pass through obese barrier deliver...
Importance Diagnosing solid lesions in the pancreas via endoscopic ultrasonographic (EUS) images is challenging. Artificial intelligence (AI) has potential to help with such diagnosis, but existing AI models focus solely on a single modality. Objective To advance clinical diagnosis of through developing multimodal model integrating both information and EUS images. Design, Setting, Participants In this randomized crossover trial conducted from January 1 June 30, 2023, 4 centers across China,...
Abstract Aim Low‐grade inflammation is the hallmark of non‐alcoholic fatty liver diseases (NAFLD) and steatohepatitis (NASH). The leakage microbiota‐derived products can contribute to during NAFLD/NASH development. Here, we assessed roles gut microbial DNA‐containing extracellular vesicles (mEVs) in regulating cellular abnormalities course NAFLD/NASH. Methods We performed studies with Vsig4 −/− , C3 cGAS their wild‐type littermate mice. Vsig4+ macrophage population bacterial DNA abundance...
Obesity induces an adaptive expansion of β cell mass and insulin secretion abnormality. Expansion adipose tissue macrophages (ATMs) is a hallmark obesity. Here, we assessed novel role ATMs in mediating obesity-induced adaptation through the release miRNA-containing extracellular vesicles (EVs). In both vivo vitro experiments, show that ATM EVs derived from obese mice notably suppress enhance proliferation. We also observed similar phenotypes human islets after EV treatment. Importantly,...
Gut microbiota-derived extracellular vesicles (mEVs) are reported to regulate inflammatory response by delivering bacterial products into host cells. The complement receptor of the immunoglobulin superfamily macrophages (CRIg+ Mφ) could clear invading bacteria and their derivatives. Here, we investigate role CRIg+ Mφ mechanism which mEVs intestinal inflammation. We found that it is exacerbated in IBD patients colitis mice mEVs' leakage from disturbed gut microbiota, enriching microbial DNA...
Pulmonary fibrosis is an aggressive end‑stage disease. Transforming growth factor‑β1 (TGF‑β1) mediates lung fibroblast activation and essential for the progress of pulmonary fibrosis. BML‑111, a lipoxinA4 (LXA4) receptor (ALX) agonist, has been reported to possess anti‑fibrotic properties. The present study aimed elucidate whether BML‑111 inhibits TGF‑β1‑induced mouse embryo (NIH3T3 cell line) in vitro bleomycin (BLM)‑induced vivo. In experiments demonstrated that treatment NIH3T3 viability...
Calcium channel α2δ subunit is a glycosylated structural consistent of the α2 and δ peptide. Previous studies have indicated distinctive expression in rat spinal cord dorsal root ganglia (DRG). This study examined whether differential glycosylation underlies molecular basis distinct subunits. The migration patterns deglycosylated subunits from cord, DRG, brain skeletal muscle were compared Western blots. data reported indicate that there are two forms DRG different other tissues examined, at...
Abstract Obesity induces an adaptive expansion of β cell mass and insulin secretion abnormality. Here, we explore a novel role adipose tissue macrophages (ATMs) in mediating obesity-induced function proliferation through releasing miRNA-containing extracellular vesicles (EVs). ATM EVs derived from obese mice notably suppress both vivo vitro experiments, whereas there are more proliferating cells the islets treated with EVs. Depletion miRNAs blunts ability to regulate responses. miR-155,...
Objective To explore the expression level of Tim-3,the marker activated T_H 1 cells.in T lymphocytes in different sites from recipients with acute rejection.Methods The model cervical heterotopic heart transplantation was established mice Two groups were get up:the isograft group(C57BL/6→C57BL/6) and allograft group (Balb/c→C57BL/6).Lymphocytes isolated peripheral blood,spleens,draining lymph nodes grafts 3 or 6 days after transplantation.The TIM-3 CD4~+ CD8~+ subsets detected by flow...