A5062293752- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Kruppel-like factors research
- Mycobacterium research and diagnosis
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- Orthopedic Infections and Treatments
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Orthopaedic implants and arthroplasty
Soochow University
2018-2024
First Affiliated Hospital of Soochow University
2023-2024
TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding involved human cancers. However, whether how circRNAs contribute to TGF-β-induced EMT NSCLC remain vague. Here, we investigated the regulation function of RNA hsa_circ_0008305 (circPTK2) metastasis, well a link between circPTK2 transcriptional intermediary factor 1 γ (TIF1γ) NSCLC. were...
Programmed death-ligand 1 (PD-L1) is a specialized shield on tumor cells that evades the immune system. Even inhibited by PD-L1 antibodies, cycling process constantly transports from inside to outside of cells, facilitating renewal and replenishment cancer cell membrane. Herein, we develop sodium alginate hydrogel consisting elesclomol-Cu galactose induce persistent cuproptosis, leading reduction for radio-immunotherapy colon tumors. First, prefabricated synthesized immobilizing elesclomol...
AlkB homolog 5 (ALKBH5) has been revealed as a key RNA N6-methyladenosine (m6A) demethylase that is implicated in development and diseases. However, the function of ALKBH5 TGF-β-induced epithelial-mesenchymal transition (EMT) tumor metastasis non-small-cell lung cancer (NSCLC) remains unknown. Here, we firstly show expression significantly reduced metastatic NSCLC. overexpression inhibits EMT invasion NSCLC cells, whereas knockdown promotes corresponding phenotypes. suppresses...
Complete remission of colorectal cancer (CRC) is still unachievable in the majority patients by common fractionated radiotherapy, leaving risks tumor metastasis and recurrence. Herein, clinical CRC samples demonstrated a difference phosphorylation translation initiation factor eIF2α (p-eIF2α) activating transcription 4 (ATF4), whose increased expression initial X-ray irradiation led to resistance subsequent radiotherapy. The underlying mechanism studied radio-resistant CT26 cells, revealing...
Article26 March 2021Open Access Source DataTransparent process Quaking 5 suppresses TGF-β-induced EMT and cell invasion in lung adenocarcinoma Shengjie Wang orcid.org/0000-0003-0320-0377 Soochow University Laboratory of Cancer Molecular Genetics, Medical College University, Suzhou, China Department School Biology Basic Sciences, Medicine, Kangda Nanjing Lianyungang, ChinaThese authors contributed equally to this work Search for more papers by author Xin Tong Chang Li Thoracic Surgery, The...
The molecular underpinnings of lung adenocarcinoma (LUAD) metastasis remain poorly defined. Here, using human LUAD cell lines, we find that transcriptional intermediary factor 1 γ (TIF1γ) binds to TATA box binding protein (TBP) in competition with TBP-associated 15 (TAF15) and impedes TAF15/TBP-mediated interleukin 6 (IL-6) transactivation. TIF1γ modifies TAF15 through multi-mono-ubiquitylation drives nuclear export TAF15. Functionally, accelerates epithelial-mesenchymal transition (EMT)...