A5107889934- MicroRNA in disease regulation
- Seedling growth and survival studies
- Tree Root and Stability Studies
- Forest ecology and management
- Plant Virus Research Studies
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Plant and Fungal Interactions Research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Mycorrhizal Fungi and Plant Interactions
- Bioenergy crop production and management
- Bacteriophages and microbial interactions
- Cancer, Stress, Anesthesia, and Immune Response
- Mosquito-borne diseases and control
- Forest Ecology and Biodiversity Studies
- Plant Disease Resistance and Genetics
- Plant tissue culture and regeneration
- Cell death mechanisms and regulation
- Genomics and Chromatin Dynamics
- Takotsubo Cardiomyopathy and Associated Phenomena
- Nuclear Structure and Function
- IL-33, ST2, and ILC Pathways
Capital Medical University
2025
King's College London
2020-2025
Jiangsu Agri-animal Husbandry Vocational College
2025
Shenyang Agricultural University
2023-2024
Harbin Medical University
2012-2024
Anhui Agricultural University
2024
Xinjiang University
2024
The Francis Crick Institute
2024
University of Edinburgh
2023
Fujian Agriculture and Forestry University
2023
TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding involved human cancers. However, whether how circRNAs contribute to TGF-β-induced EMT NSCLC remain vague. Here, we investigated the regulation function of RNA hsa_circ_0008305 (circPTK2) metastasis, well a link between circPTK2 transcriptional intermediary factor 1 γ (TIF1γ) NSCLC. were...
Glioma, characterized by its undesirable prognosis and poor survival rate, is a serious threat to human health lives. MicroRNA-9 (miR-9) implicated in the regulation of multiple tumors, while mechanisms underlying aberrant expression functional alterations glioma are still controversial. Expressions miR-9 were measured GEO database, patient specimens cell lines. Gain- loss-of-function assays applied identify effects on cells HUVECs vitro vivo. Potential targets predicted bioinformatics...
To evaluate the effect of p53 on pyroptosis and its inhibitory role tumor growth in non-small-cell lung cancer (NSCLC). The correlation was determined tissues NSCLC patients. pyroptotic level detected A549 cells to clarify pyroptosis. overexpression tumor-bearing mice were used therapeutic target treatment. expression positively related tissues. In vitro assays, directly regulated cells. p53-specific knockdown blocked lipopolysaccharide- (LPS-) induced vivo markedly decreased death rate by...
Abstract Non-small cell lung cancer (NSCLC), one of the most common causes cancer-related death, is a worldwide public health problem. MicroRNAs (miRNAs) have recently been identified as novel class regulators carcinogenesis and tumor progression, including miRNAs associated with NSCLC. This study aimed to explore role miR-522 in NSCLC mechanisms underlying this role. We report here that expression was significantly increased both human tissues lines. Furthermore, an MTT assay,...
A highly chemo- and regioselective 1,4-aminomethylamination of simple enynes with aminals to allenic 1,5-diamines by taking advantage C–N bond activation has been reported. The reaction proceeds under mild conditions can be performed lower catalyst loading (0.1 mol %) high efficiency broad substrate scope.
The plant genome can produce long non-coding RNAs (lncRNAs), some of which have been identified as important regulators gene expression. To better understand the response mechanism rice plants to Rice black-streaked dwarf virus (RBSDV) infection, we performed a comparative transcriptome analysis between RBSDV-infected and non-infected plants. A total 1342 mRNAs 22 lncRNAs were be differentially expressed after RBSDV infection. Most transcripts involved in plant–pathogen interaction pathway...
Proteins are subject to aging in the form of spontaneous, nonenzymatic post-translational modifications (PTMs). One such PTM is formation β-linked isomer l-isoaspartic acid (isoAsp) from aspartic (Asp) or asparagine residues, which tends occur long-lived proteins. Histones can exhibit half-lives on order 100 days, and unsurprisingly, isoAsp has been observed nearly every histone family. Delineating molecular consequences histones challenging due multitude processes that time scales. To...
Abstract Rice black‐streaked dwarf virus disease (RBSDVD) poses a severe threat to rice production in China. Currently, the resistance levels of varieties this are evaluated based on incidence rate, which is singular criterion that fails capture nuanced differences among cultivars with similar levels. This study reveals positive correlation between severity RBSDVD and degree plant dwarfing. We propose refined evaluation method using dwarfing index (PDI) assess different varieties. By...
ABSTRACT Background Berberine (BBR) enhances the production of levodopa in gut microbes, which is converted to dopamine brain Parkinson's disease (PD). However, limited research has explored effects BBR on non‐motor symptoms, such as depression and gastrointestinal (GI) dysfunction PD. Methods 6‐hydroxydopamine‐induced (6‐OHDA) PD rats were utilized this study, depression‐like behaviors detected via sucrose preference test open field test. Key Results The 6‐OHDA exhibited behaviors, delayed...
The mitochondrial complexes are prone to sirtuin (Sirt)3‐mediated deacetylation modification, which may determine cellular response stimuli, such as oxidative stress. In this study, we show that the cytochrome c oxidase (COX)‐1, a core catalytic subunit of complex IV, was acetylated and deactivated both in 2, 2'‐azobis(2‐amidinopropane) dihydrochloride‐treated NIH/3T3 cells hydrogen peroxide‐treated primary neuronal cells, correlating with apoptotic cell death induction by Inhibition Sirt3...
The movement of plant viruses is a complex process that requires support by the virus-encoded protein and multiple host factors. unfolded response (UPR) plays important roles in virus infection, while how UPR regulates viral infection remains to be elucidated. Here, we show rice stripe (RSV) elicits Nicotiana benthamiana . RSV-induced activates autophagy pathway which RSV-encoded protein, NSvc4, targeted for autophagic degradation. As counteract, revealed NSvc4 hijacks UPR-activated type-I...
The main purpose of this study was to the changes in growth, root system, and tissue anatomical structure Pinus sylvestris var. mongolica under soil drought conditions. In study, growth indexes photosynthesis P. seedlings stress were studied by pot cultivation. Continuous water control experiment indoor culture carried out, ensuring that content each treatment reached 80%, 40%, 20% field moisture capacity as control, moderate severe drought, respectively. submicroscopic structures needles...
Background: SLC30A5, a member of the solute transporter protein family, is implicated in tumorigenesis and cancer progression.This study aimed to explore expression prognostic significance SLC30A family genes pan-cancer, with specific emphasis on SLC30A5 hepatocellular carcinoma (HCC).Methods: Expression patterns implications were assessed across 33 types, especially HCC.Co-expression analysis explored relationship between immune cell infiltration, checkpoints, pathway molecules related...
MiRNAs, as a kind of key regulators in gene expression, play vital roles numerous life activities from cellular proliferation and differentiation to development immunity. However, little is known about the regulatory manner miRNAs Asian honey bee (Apis cerana) guts. Here, on basis our previously gained high-quality transcriptome data, transcriptome-wide identification larval guts Apis cerana was conducted, followed by investigation miRNAs' differential expression profile during gut...
Abstract The unfolded protein response (UPR) plays important roles in plant virus infection. Our previous study has proved that rice stripe (RSV) infection elicits host UPR. However, the mechanism on how UPR is triggered upon RSV remains obscure. Here, we show bZIP17/28 branch of signalling pathway activated Nicotiana benthamiana . We found membrane‐associated proteins NSvc2 and NSvc4 encoded by are responsible for activation branch. Ectopic expression or leaves induced proteolytic...
Picornaviruses cause diseases in a wide range of vertebrates, invertebrates and plants. Here, novel picornavirus was identified by RNA-seq technology from rice plants showing dwarfing curling symptoms, the name curl dwarf-associated virus (RCDaV) is tentatively proposed. The RCDaV genome consists an 8,987 nt positive-stranded RNA molecule, excluding poly(A) tail, that encodes two large polyproteins. Using vitro cleavage assays, we have 3C protease (3Cpro) as serine recognizes conserved EPT/S...
Abstract Background Histone epigenetic modification disorder is an important predisposing factor for the occurrence and development of many cancers, including colorectal cancer (CRC). The role MYSM1, a metalloprotease that deubiquitinates monoubiquitinated histone H2A, in was identified to evaluate its potential clinical application value. Methods MYSM1 expression levels CRC cell lines tumor tissues were detected, their associations with patient survival rate stage analyzed using databases...
Proteins are subject to spontaneous rearrangements of their backbones. Most prominently, asparagine and aspartate residues isomerize β-linked isomer, isoaspartate (isoAsp), on time scales ranging from days centuries. Such modifications typically considered "molecular wear-and-tear", destroying protein function. However, the observation that some proteins, including essential bacterial enzyme MurA, harbor stoichiometric amounts isoAsp suggests this modification can confer advantageous...