A5100650129- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Obsessive-Compulsive Spectrum Disorders
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Botulinum Toxin and Related Neurological Disorders
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Eating Disorders and Behaviors
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neural Engineering
- Body Image and Dysmorphia Studies
- Pharmacological Effects and Toxicity Studies
- Schizophrenia research and treatment
- Neural and Behavioral Psychology Studies
- Autism Spectrum Disorder Research
- Musculoskeletal pain and rehabilitation
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Pain Management and Placebo Effect
- Phytoplasmas and Hemiptera pathogens
- Advanced MRI Techniques and Applications
Shanghai Jiao Tong University
2016-2025
Ruijin Hospital
2016-2025
Peking University
2022
Peking University Third Hospital
2022
Functional Technologies (United Kingdom)
2017
Shanghai Mental Health Center
2014-2017
Abstract Parkinson’s disease (PD) is characterised by the emergence of beta frequency oscillatory synchronisation across cortico-basal-ganglia circuit. The relationship between anatomy this circuit and within it remains unclear. We address combining recordings from human subthalamic nucleus (STN) internal globus pallidus (GPi) with magnetoencephalography, tractography computational modelling. Coherence supplementary motor area STN high (21–30 Hz) but not low (13-21 range correlated...
ABSTRACT Background Deep brain stimulation has generated sustained improvement in motor function for patients with dystonia, but the long‐term impact of subthalamic nucleus on dystonia not been elucidated. Methods Patients primary underwent bilateral and were evaluated Burke–Fahn–Marsden rating scale Medical Outcomes Study 36‐item Short‐Form General Health Survey at baseline 1 month, year, 3 to 10 years postoperatively. Results Improvements according 55%, 77%, 79%, respectively. The quality...
Given that anorexia nervosa (AN) is a life-threatening mental disorder and has poor clinical outcomes, novel effective treatments are warranted, especially for severe persistent cases.To investigate the safety, feasibility, outcomes of using deep brain stimulation (DBS) nucleus accumbens (NAcc) in treatment-refractory AN patients.A total 28 women with refractory underwent NAcc-DBS completed this 2-year follow-up study. The including body mass index (BMI) mood, anxiety, obsessive symptoms,...
OBJECTIVE Subthalamic nucleus deep brain stimulation has been shown to be effective in reducing symptoms of primary Meige syndrome. However, assessments its efficacy and safety have limited several case reports small studies. METHODS The authors performed a retrospective study assess the bilateral subthalamic 15 patients with syndrome who responded poorly medical treatments or botulinum toxin injections. Using movement disability subscores Burke-Fahn-Marsden Dystonia Rating Scale, evaluated...
Neurophysiological work in primates and rodents have shown the amygdala plays a central role reward processing through connectivity with orbitofrontal cortex (OFC) hippocampus. However, understanding of oscillations each region their different stages humans has been hampered by limitations noninvasive methods such as poor spatial temporal resolution. To overcome these limitations, we recorded local field potentials (LFPs) directly from amygdala, OFC hippocampus simultaneously human male...
In this study, we investigate the modification to cortical oscillations of patients with Parkinson disease (PD) by subthalamic deep brain stimulation (STN-DBS).Spontaneous PD were recorded magnetoencephalography during on and off nucleus states. Several features such as average frequency, power, relative subband power in regions interest extracted frequency domain, these correlated Unified Disease Rating Scale III evaluation. The same also investigated without surgery healthy...
Deep brain stimulation (DBS) is a well-established therapy for the treatment of advanced Parkinson's disease (PD) in patients experiencing motor fluctuations and medication-refractory tremor. Despite relative tolerability safety this procedure, associated complications unnatural deaths are still unavoidable.In study, hardware-related causes death were retrospectively analyzed 478 with PD who treated DBS.The results showed 3-year survival rate 98.6% 5-year 96.4% underwent DBS at study center....
Parkinson's disease (PD) is a movement disorder caused by dopaminergic neurodegeneration. Levodopa (L-dopa) an effective medication for alleviating motor symptoms in PD that has been shown previously to reduce subcortical beta (13-30 Hz) oscillations. How L-dopa influences oscillations the cortex unclear. In this study, 21 patients were recorded with magnetoencephalography (MEG) ON and OFF states. Oscillatory components of resting-state power spectra compared between two states significant...
Late-life depression (LLD) has negative impacts on somatic, emotional and cognitive domains of the lives patients. Elucidating abnormality in brain networks LLD patients could help to strengthen understanding pathophysiology, however, studies exploring spontaneous activity during resting state remain limited. This study aimed at identifying voxel-level whole-brain functional connectivity changes patients.Fifty with late-life 33 healthy controls were recruited. All participants underwent a...
Lateral habenula is believed to encode negative motivational stimuli and plays key roles in the pathophysiology of psychiatric disorders. However, how activities are modulated during processing emotional information still poorly understood. We recorded local field potentials from bilateral areas with simultaneous cortical magnetoencephalography nine patients disorders an picture-viewing task. Transient activity theta/alpha band (5–10 Hz) within prefrontal regions, as well coupling between...
OBJECTIVE Treatment-resistant depression (TRD) is a severely disabling psychiatric condition that responds poorly to conventional treatments. Deep brain stimulation (DBS) has been proposed for the treatment of patients with TRD in numerous studies. Several deep nuclei are considered as potential targets TRD-DBS, but their clinical efficacy needs further validation. This study carried out dual-target combined bed nucleus stria terminalis (BNST) and accumbens (NAc) investigate effectiveness...
Abstract Over the past decades, immune responses have been suspected of participating in mechanisms for epilepsy. To assess related pathway temporal lobe epilepsy (TLE), we explored altered pathways TLE patients with and without hippocampal sclerosis (HS). We analyzed RNA-seq data from 3 TLE-HS TLE-nonHS patients, including identification differentially expressed RNA, function enrichment, protein–protein interaction network construction ceRNA regulatory network. illustrated landscape...
Objectives Parkinson's disease (PD) is a neurodegenerative disorder that can cause motor impairments and gait problems. Non-invasive electrophysiological biomarkers like phase amplitude coupling (PAC) hold promise for understanding managing PD. This study aims to investigate the modulations of levodopa locomotion in cortical cortico-muscular beta-gamma PAC by monitoring central EEG (cEEG) gastrocnemius EMG (gEMG) discuss their potential utility as impairments. Methods The cEEGs gEMGs were...
Bilateral anterior capsulotomy and deep brain stimulation (DBS) of the nucleus accumbens (NAc) represent investigational treatment options for severe, treatment-refractory anorexia nervosa (AN). However, follow-up studies evaluating postoperative outcomes in these patients remain limited, clinical neuroanatomical characteristics associated with response have yet to be elucidated. The retrospective study analyzed preoperative imaging data AN who underwent bilateral or DBS from 2019 2023....