A5083727290- Pituitary Gland Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Intracranial Aneurysms: Treatment and Complications
- Neurofibromatosis and Schwannoma Cases
- Kruppel-like factors research
- Functional Brain Connectivity Studies
- Ubiquitin and proteasome pathways
- Cerebrospinal fluid and hydrocephalus
- Autophagy in Disease and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- interferon and immune responses
- Growth Hormone and Insulin-like Growth Factors
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurosurgical Procedures and Complications
- Neurological disorders and treatments
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Hippo pathway signaling and YAP/TAZ
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Ministry of Science ICT and Future Planning
2024
Fudan University
2024
Renji Hospital
2014-2015
United States Government Accountability Office
2014
Changzhou No.2 People's Hospital
2014
Philipps University of Marburg
2005
Intracerebral hemorrhage (ICH) has a high morbidity and mortality rate. Excessive reactive oxygen species (ROS) caused by primary second brain injury can induce neuron death inhibit neurological functional recovery after ICH. Therefore, exploring an effective way to noninvasively target sites scavenge ROS is urgently needed. Inspired the biological function of platelets vessel repair blood vessels, platelet-membrane-modified polydopamine (Menp@PLT) nanoparticles are developed with targeting...
Previous studies revealed that curcumin is neuroprotective in diseases of the central nervous system such as cerebral ischemia and traumatic brain injury. However, effect on intracerebral hemorrhage remains unclear. We, therefore, investigated pre-clinical treatment neurological outcomes following hemorrhage, using a mouse model. Intracerebral was induced by autologous blood injection into right basal ganglia. Curcumin (150 mg/kg) administered 15 min after hemorrhage. Grid walk scores were...
Two recent whole-exome sequencing researches identifying somatic mutations in the ubiquitin-specific protease 8 (USP8) gene pituitary corticotroph adenomas provide exciting advances this field. These drive increased epidermal growth factor receptor (EGFR) signaling and promote adrenocorticotropic hormone (ACTH) production. This study was to investigate whether inhibition of USP8 activity could be a strategy for treatment Cushing's disease (CD).The anticancer effect inhibitor determined by...
Free radical damage caused by ferrous iron is involved in the pathogenesis of secondary brain injury after intracerebral hemorrhage (ICH). NF-E2-related factor 2 (Nrf2), a major phase II gene regulator that binds to antioxidant response element, represents an important cellular cytoprotective mechanism against oxidative damage. We hypothesized Nrf2 might protect astrocytes from Fe2+. Therefore, we examined cytotoxicity primary induced overload and evaluated effects Fe2+ on expression. The...
Intracerebral hemorrhage (ICH) is a particularly severe form of stroke, and reactive astrogliosis common response following injury to the central nervous system (CNS). Mesenchymal stem cells (MSCs) are reported promote neurogenesis alleviate late side effects in injured brain regions. Gap junctions (Gjs) abundant brain, where richest connexin (Cx) Cx43, most prominently expressed astrocytes. Nuclear factor erythroid 2-related 2 (Nrf2) an essential transcription regulating antioxidant...
Recent investigations have revealed that oxidative stress can lead to neuronal damage and disrupt mitochondrial endoplasmic reticulum functions after intracerebral hemorrhage (ICH). However, there is limited evidence elucidating their role in maintaining homeostasis. Metabolomics analysis, RNA sequencing, CUT&Tag-seq were performed investigate the mechanism underlying interaction between PERK/ATF4 branch of (ERS) one-carbon (1C) metabolism during resistance stress. The association 1C ERS ICH...
The malignant glioma remains one of the most aggressive human malignancies with extremely poor prognosis. Glioma cell invasion and migration are main causes death. In current study, we studied expression potential functions tetraspanin 8 (Tspan8) in gliomas. We found that Tspan8 level is high both tissues several lines, where it formed a complex integrin α3 rictor, latter key component mammalian target rapamycin (mTOR) 2 (mTORC2). Disruption this complex, through siRNA-mediated knockdown...
Cushing's disease is primarily caused by pituitary adrenocorticotropin‑secreting adenoma. However, its pathogenesis has remained obscure. In the present study, whole transcriptome analysis was performed RNA sequencing (RNA‑Seq) and expression of secreted frizzled‑related protein 2 (SFRP2) decreased in corticotroph tumors compared with normal glands. Furthermore, RNA‑Seq results were validated SFRP2 tumor tissues analyzed comparing another cohort 23 patients 3 human samples using reverse...
Context and objective Cushing's disease (CD) provides a unique naturalist model for studying the influence of hypercortisolism on human brain reversibility these effects after resolution condition. This cross-sectional study used resting-state fMRI (rs-fMRI) to investigate altered spontaneous activity in CD patients trends potential hypercortisolism. We also aim determine relationship changes with clinical characteristics cortisol levels. Subjects methods Active (n = 18), remitted 14)...
Secondary injury mediated by oxidative stress leads to deterioration of neurological function after intracerebral hemorrhage (ICH). Cortical astrocytes are one the most important cells in central nervous system (CNS). It is absolutely critical maintain redox homeostasis protecting stress. Hemin a product hemoglobin degradation, which has strong toxicity and can induce reactive oxygen species (ROS). Melatonin (Mel) its metabolites well tolerated without toxicity, prevent tissue damage as...
OBJECTIVE Treatment-resistant depression (TRD) is a severely disabling psychiatric condition that responds poorly to conventional treatments. Deep brain stimulation (DBS) has been proposed for the treatment of patients with TRD in numerous studies. Several deep nuclei are considered as potential targets TRD-DBS, but their clinical efficacy needs further validation. This study carried out dual-target combined bed nucleus stria terminalis (BNST) and accumbens (NAc) investigate effectiveness...