A5087576440- Ion Channels and Receptors
- Ocular Surface and Contact Lens
- Neurobiology and Insect Physiology Research
- Mast cells and histamine
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Amino Acid Enzymes and Metabolism
- Glaucoma and retinal disorders
- Cell death mechanisms and regulation
- Herbal Medicine Research Studies
- Corneal Surgery and Treatments
- Sulfur Compounds in Biology
- Phytochemicals and Antioxidant Activities
- Click Chemistry and Applications
- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
- Retinal Diseases and Treatments
- Ferrocene Chemistry and Applications
- Dermatology and Skin Diseases
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- Skin Protection and Aging
- Trace Elements in Health
- Marine Biology and Environmental Chemistry
- Urticaria and Related Conditions
AbbVie (United States)
2024
University of Alabama at Birmingham
2020
Allergan (United States)
2007-2020
Scripps Research Institute
2008
Genomics Institute of the Novartis Research Foundation
2003-2007
University of Southern California
1999-2003
TRPA1 is a member of the transient receptor potential (TRP) family ion channels and expressed in subset nociceptive neurons. An increasing body evidence suggests that functions as chemical nocisensor for variety reactive chemicals, such pungent natural compounds environmental irritants. Activation by has been demonstrated to be mediated through covalent modification cytoplasmic cysteines located N terminus channel, rather than classical lock-and-key binding. activity also modulated numerous...
Parkinson's disease (PD) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity are both associated with dopaminergic neuron death in the substantia nigra (SN). Apoptosis has been implicated this cell loss; however, whether or not it is a major component of pathology remains controversial. Caspases class proteases involved apoptotic process. To evaluate role caspases PD, we analyzed caspase activation MPTP-treated mice, cultured cells, postmortem PD brain tissue. MPTP was found to...
N-methyl-D-aspartate (NMDA) receptors play critical roles in synaptic transmission and plasticity. Activation of NMDA by synaptically released L-glutamate also requires occupancy co-agonist binding sites the tetrameric receptor either glycine or D-serine. Although D-serine appears to be predominant at receptors, transport mechanisms involved homeostasis brain are poorly understood. In this work we show that SLC1 amino acid transporter family members SLC1A4 (ASCT1) SLC1A5 (ASCT2) mediate...
Mas-related G protein-coupled receptor X2 (MRGPRX2) is a promiscuous on mast cells that mediates IgE-independent degranulation and has been implicated in multiple cell-mediated disorders, including chronic urticaria, atopic dermatitis, pain disorders. Although it promising therapeutic target, few potent, selective, small molecule antagonists have identified, functional effects of human MRGPRX2 inhibition not evaluated vivo.
The herb rosemary has been reported to have antioxidant and anti-inflammatory activity. We previously shown that carnosic acid (CA), present in extract, crosses the blood-brain barrier exert neuroprotective effects by upregulating endogenous enzymes via Nrf2 transcriptional pathway. Here we investigated activity of CA retinal cell lines exposed oxidative stress a rat model light-induced degeneration (LIRD).Retina-derived ARPE-19 661W treated with hydrogen peroxide were used as vitro models...
Visceral pain disorders such as interstitial cystitis/bladder syndrome (IC/BPS) and irritable bowel (IBS) often manifest concurrently in the bladder colon. Yet, mechanistic basis of comorbidities transmission neural hypersensitivity across organ systems has remained a mystery. Here, we identify mast cell-sensory neuron circuit that initiates inflammation simultaneously propagates to colon murine model IC/BPS. We unveil anatomic heterogeneity cells relation nociceptors their critical...
The first and rate-limiting reaction in the formation of glutathione is catalyzed by gamma-glutamylcysteine synthetase (GCS), a dimer composed catalytic heavy regulatory light subunit. We previously found that subunit GCS mRNA appears to be expressed at high levels hippocampus, cerebellum, cortex murine brain lower neostriatum (Kang et al. [1997] NeuroReport 8:2053). Here we report variations expression resembles with few minor exceptions. Moreover, activity various regions appear correspond...
Apoptosis is a cell-suicide process that appears to play central role not only during normal neuronal development but also in several neuropathological disease states. An important component of this proteolytic cascade involving family cysteine proteases called caspases. Caspase inhibitors have been demonstrated be effective inhibiting cell death various apoptotic paradigms. We created transgenic mice neuronally express the baculoviral caspase inhibitor p35. Neuronal expression p35 protein...
Catecholamines binding to α- and β-adrenergic receptors on immune cells have recently been shown play an important role in regulating responses. Although α2-adrenergic are known modulate the response different ways, therapeutic exploration of their utility has limited by lack agonists selective for three subtypes. We report this study identification agonist AGN-762, which activates α2B- α2C-adrenergic subtypes, but not α2A subtype. show that AGN-762 reduced clinical disease experimental...