A5029892759- TGF-β signaling in diseases
- Drug-Induced Adverse Reactions
- Geriatric Care and Nursing Homes
- Cardiac Arrest and Resuscitation
- Heterotopic Ossification and Related Conditions
- Dermatology and Skin Diseases
- Kruppel-like factors research
- Urticaria and Related Conditions
- Cancer Cells and Metastasis
- Palliative Care and End-of-Life Issues
- Endometriosis Research and Treatment
- Evacuation and Crowd Dynamics
- Neonatal skin health care
- Ultrasound in Clinical Applications
- Dementia and Cognitive Impairment Research
- Inflammatory mediators and NSAID effects
- Older Adults Driving Studies
- Phytoplasmas and Hemiptera pathogens
- Nail Diseases and Treatments
- Tea Polyphenols and Effects
- Consumer Packaging Perceptions and Trends
- Plant and Fungal Interactions Research
- Synthesis of β-Lactam Compounds
- Technology Use by Older Adults
- Family and Patient Care in Intensive Care Units
Yakult Honsha (Japan)
2025
National Center For Child Health and Development
2022-2024
Gakushuin University
2022
Science for Life Laboratory
2020-2021
Uppsala University
2020-2021
Tokyo Dental College Ichikawa General Hospital
2021
Keio University
2003-2021
Utsunomiya University
2021
Rio de Janeiro Federal Institute of Education, Science and Technology
2017
Ehime University
2015
ObjectiveDementia is a major public health problem. More and more patients with dementia are being admitted to acute care hospitals for treatment of comorbidities. Issues associated in have not been adequately clarified. This study aimed explore the challenges nurses face providing Japan.MethodsThis was qualitative using focus group interviews (FGIs). The setting six surgical medical wards western region Japan. Participants were internal medicine wards, excluding intensive units. Nurses less...
Abstract BMP signaling has been found to have tumor-promoting as well tumor-suppressing effects in different types of tumors. In this study, we investigated the and inhibitors on ovarian cancer (OC) cells vitro vivo. High expression receptor 2 (BMPR2) correlated with poor overall survival OC patients TCGA dataset. Both BMP2 BMPR2 enhanced cell proliferation, whereas kinase inhibited growth culture a mouse model. also augmented sphere formation, migration, invasion cells, induced EMT. was...
The effects of bone morphogenetic proteins (BMPs), members the transforming growth factor-β (TGF-β) family, in endometrial cancer (EC) have yet to be determined. In this study, we analyzed TCGA and MSK-IMPACT datasets investigated BMP2 TWSG1, a BMP antagonist, on Ishikawa EC cells. Frequent ACVR1 mutations high mRNA expressions ligands receptors were observed patients datasets. cells secreted higher amounts compared with ovarian cell lines. Exogenous stimulation enhanced sphere formation via...
We previously reported that bone morphogenetic protein (BMP) signaling promotes tumorigenesis in gynecologic cancer cells. BMP2 enhances proliferation of ovarian and endometrial cells via c-KIT induction, triggers epithelial-mesenchymal transition (EMT) by SNAIL and/or SLUG leading to increased cell migration. However, the downstream effectors BMP gynecological have not been clearly elucidated. In this study, we performed RNA-sequencing Ishikawa SKOV3 after stimulation, identified TNFRSF12A,...
Abstract Objective Little is known about caregiver experiences during the end‐of‐life period. Our objective was to characterize perceptions of their in cancer survivorship with special reference stage considering depression bereavement. Methods Qualitative research using in‐depth interviews 34 caregivers from two palliative care units Japan. Data were analyzed inductively framework analysis. Depression and personality traits measured Center for Epidemiological Studies (CES‐D) Sense Coherence...
Abstract Background: To date, medical schools and clinical training hospitals in Japan that require students to show immunity for measles, mumps, rubella, varicella (chickenpox), hepatitis B prior the commencement of residency are limited. Methods: This qualitative study used focus group interviews elucidate why do not undergo vaccination. A total three groups were identified interviewed: (two men, women), two C (three women). All recorded transcribed verbatim analyzed according constant...
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), severe drug reactions, are often misdiagnosed due to their rarity lack of information on differential diagnosis. The objective the study was develop an electronic medical record (EMR)-based algorithm identify patients with SJS/TEN for future application in database studies. From EMRs a university hospital, two dermatologists identified all 13 seen at Department Dermatology as case group. Another 1472 who visited were using...
Colostrum is the first food for newborns and it contains various crucial immune factors. The concentrations of factors in breast milk may change depending on maternal characteristics such as body mass index, collection day, age at pregnancy. In this exploratory study, we investigated association between TGF-β1, TGF-β2, IgA colostrum rarely studied that affect components, including use labor-inducing medication, secretion, sex newborns, or nipple problems, care. Breast samples were collected...
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Breast milk contains numerous factors that are involved in the maturation of immune system and development gut microbiota infants. These include transforming growth factor-β1 2, immunoglobin A, lactoferrin. may also affect epidermal differentiation stratum corneum (SC) barrier infants, but no studies examining these associations over time during infancy have been reported. In this single-center exploratory study, we measured molecular components SC using confocal Raman spectroscopy at 0, 1,...
Natto (fermented soybeans)-induced hypersensitivity is characterized by delayed symptom onset that hampers diagnosis. We aimed to clarify the clinical utility of basophil activation test (BAT) in diagnosis natto-induced hypersensitivity.Five patients with a history anaphylaxis and chronic urticaria suspected seven spontaneous clinically unrelated natto were enrolled patient control groups, respectively. The BAT was performed two incubation times, 15 min 1 h, combination various...
Objective : Complex physical therapy (CPT) has recently become the therapeutic focus for managing secondary lymphedema. Although it is advisable to perform CPT every day, only a few of our patients with lymphedema currently maintain this regimen. The aims study were (1) assess self-care practices that employed by lower extremity lymphedema, and (2) determine relationship between continuation self-efficacy in these patients. Methods This cross-sectional was conducted at Kyoto University...