A5062825254- Cancer and Skin Lesions
- Nonmelanoma Skin Cancer Studies
- Lung Cancer Treatments and Mutations
- Hedgehog Signaling Pathway Studies
- Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Textile materials and evaluations
- Radioactivity and Radon Measurements
- Cancer Immunotherapy and Biomarkers
- Radioactive contamination and transfer
- Color perception and design
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders
- Cutaneous lymphoproliferative disorders research
- Polyomavirus and related diseases
- Lung Cancer Diagnosis and Treatment
- Color Science and Applications
- Ear and Head Tumors
- Hepatocellular Carcinoma Treatment and Prognosis
- Heavy metals in environment
- Muscle activation and electromyography studies
- Multiple and Secondary Primary Cancers
- Cardiac tumors and thrombi
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
Keio University
2017-2025
Weatherford College
2020
Saiseikai Kanagawa Hospital
2017
Yokohama City University
2015
Saiseikai Ibaraki Hospital
2014-2015
Otsuma Women's University
1990-2012
Park Terrace Care Center
2007
Anticancer Fund
2002
AntiCancer (United States)
2002
The University of Tokyo
2001
Abstract In long-term dose assessment models for radioactive waste disposal, an important exposure pathway to humans is via ingestion of contaminated foods. order obtain soil-to-plant transfer factors (TFs) radionuclides under equilibrium conditions, naturally existing elements were measured as analogues radionuclides. Crops grown in upland fields and associated soil samples collected from 62 sampling sites throughout Japan. The total concentrations 52 the crops 54 measured. TFs 40 (Li, Na,...
No consensus has been reached regarding the optimal chemotherapy for metastatic extramammary Paget's disease (EMPD), a rare cutaneous adenocarcinoma, because of lack solid evidence from prospective trials. However, immunohistochemical profile EMPD reportedly resembles that breast cancer, particularly in terms human epidermal growth factor receptor 2 (HER2) expression, suggesting HER2 is promising therapeutic target advanced HER2-positive EMPD.
Abstract The critical paths of radionuclides and the foods in Japan are different from those European North American countries because agricultural products food customs different. Consequently, safety assessment is required to consider rice vegetables as foods. In this study, we measured soil-to-plant transfer factors (TFs) for using naturally existing elements analogues under equilibrium conditions. Rice associated soil samples were collected 50 sampling sites throughout TFs 36 34 brown...
Abstract Background Immune checkpoint inhibitors (ICIs) have demonstrated efficacy over previous cytotoxic chemotherapies in clinical trials among various tumors. Despite their favorable outcomes, they are associated with a unique set of toxicities termed as immune-related adverse events (irAEs). Among the toxicities, ICI-related pneumonitis has poor outcomes little understanding its risk factors. This retrospective study aimed to investigate whether pre-existing interstitial lung...
In long-term dose assessment models for radioactive waste disposal, an important exposure pathway to humans is via ingestion of contaminated foods. order obtain soil-to-plant transfer factors (TFs) radionuclides under equilibrium conditions, naturally existing elements were measured as analogues radionuclides. Crops grown in upland fields and associated soil samples collected from 62 sampling sites throughout Japan. The total concentrations 52 the crops 54 measured. TFs 40 (Li, Na, Mg, Al,...
Abstract Extramammary Paget's disease (EMPD) is a rare cutaneous adenocarcinoma that clinicopathologically resembles breast cancer. The prognosis of metastatic EMPD poor. Although several chemotherapies have been tried, the effects are temporary; better drugs and combinations required. In present study, we retrospectively analyze efficacy safety combination cisplatin, epirubicin, paclitaxel in five cases. was than for previously reported regimens: 80% partial responses, including two...
Malignant cutaneous epithelial tumors comprise various skin malignancies originating from the epithelium, including squamous cell carcinoma, basal and malignant adnexal tumors. Treatment options are limited, as rarity of these tumors, especially among Asians, renders well-controlled clinical trials extremely challenging to conduct. Thus, we designed a trial evaluate efficacy safety anti-programmed death-1 (PD-1) monoclonal antibody nivolumab in patients with metastatic carcinomas other rare
To evaluate the feasibility of adoptive cell therapy (ACT) using ex vivo-expanded tumor-infiltrating lymphocytes (TILs) in Japanese patients with melanoma who failed immune-checkpoint inhibitor therapy, an open-label, single-arm, pilot study was conducted. We investigated immunological and genetic factors pretreatment tumor expanded TILs that may be associated clinical response. The treatment protocol comprised preparation TIL culture, lympho-depleting non-myeloablative preconditioning...
The critical paths of radionuclides and the foods in Japan are different from those European North American countries because agricultural products food customs different. Consequently, safety assessment is required to consider rice vegetables as foods. In this study, we measured soil-to-plant transfer factors (TFs) for using naturally existing elements analogues under equilibrium conditions. Rice associated soil samples were collected 50 sampling sites throughout TFs 36 34 brown white rice,...
Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma affecting the genitals and axillary regions. As metastasis of these tumours itself rare, solid management strategies have not been established. Serum carcinoembryonic antigen (CEA) cytokeratin 19 fragment 21‐1 (CYFRA 21‐1) levels identified as candidate biomarkers for tumour progression in EMPD. To determine accuracy correlation between markers patients with CEA CYFRA were examined 30 EMPD treated at Keio University...
Abstract Monthly docetaxel (DTX) monotherapy is the first‐line regimen that preferably used for metastatic extramammary Paget’s disease (EMPD). However, high‐dose DTX frequently causes severe hematological adverse events (AE). To overcome such safety concerns, a weekly low‐dose has been proposed use in treatment of various cancer types. In this study, we aimed to evaluate feasibility and efficacy (25 mg/m 2 ) EMPD by retrospectively analyzing clinical courses 14 patients treated with...
Abstract Metastatic extramammary Paget's disease ( EMPD ) is a rare cancer with no standardized treatment. We report two cases of metastatic treated modified weekly PET (cisplatin, epirubicin and paclitaxel) regimen given biweekly (i.e. 2 weeks on/2 off) that had durable responses. Case 1 was 74‐year‐old man to lymph nodes, lung, bone who presented hemorrhagic tumor on the scrotum. tried weekly, but adjusted interval after doses because hematological side‐effects. After five doses, he showed...
Extramammary Paget disease (EMPD) is a rare cutaneous malignant neoplasm arising in apocrine gland-rich areas. Although - like normal glands EMPD frequently expresses androgen receptor (AR), the clinical significance of AR expression remains unclear. The present study investigated clinicopathological impact EMPD. Immunohistochemistry for was performed retrospective cohort 92 patients with 108 lesions, including 102 primary five lymph node [LN] metastases and one local recurrence. total...