A5080704857- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Carbohydrate Chemistry and Synthesis
- Axial and Atropisomeric Chirality Synthesis
- Molecular spectroscopy and chirality
- Glycosylation and Glycoproteins Research
- Neuroblastoma Research and Treatments
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Reactions
- Cyclopropane Reaction Mechanisms
- Crystallography and molecular interactions
- Chemical synthesis and alkaloids
- Fluorine in Organic Chemistry
- Galectins and Cancer Biology
- Polyoxometalates: Synthesis and Applications
- Asymmetric Hydrogenation and Catalysis
- Signaling Pathways in Disease
- Catalytic Cross-Coupling Reactions
- Diabetic Foot Ulcer Assessment and Management
- Cancer therapeutics and mechanisms
- Enzyme Production and Characterization
- Microbial Metabolites in Food Biotechnology
- Innovative Microfluidic and Catalytic Techniques Innovation
Tokyo University of Science
1996-2025
Teikyo University
2009-2018
The University of Tokyo
1989-2008
Nagoya University
1976-2001
Chiba University
1988-1998
Saitama Cancer Center
1998
Nagoya University Hospital
1998
Kansai Medical University
1998
Chiba Cancer Center
1998
Sagami Chemical Research Institute
1994-1995
An assembled insoluble catalyst, PdAS, prepared from palladium ((NH4)2PdCl4 (1)) and non-cross-linked amphiphilic copolymer poly(N-isopropylacrylamide-co-4-diphenylstyrylphosphine) (2) was developed. It found that PdAS is an excellent catalyst for the Suzuki-Miyaura reaction on three points: (1) The use of 8 x 10(-7) to 5 10(-4) mol equiv afforded coupling products efficiently after easy workup, with turnover number reaching up 1,250,000. reusable many times without loss catalytic activity....
One hundred nine newly treated patients with advanced neuroblastoma were entered in this study between January 1985 and May 1989. The eligible included infants younger than 12 months of age Stage IVA disease (bone cortex, distant lymph node, and/or remote organ metastases) aged or older III IV (IVA plus IVB tumor crossing the mid-line metastases confined to bone marrow, liver, skin). first received six cyclic course intensive chemotherapy (regimen A1), consisting cyclophosphamide (1200...
Steroid and xenobiotic receptor (SXR) is activated by endogenous exogenous chemicals including steroids, bile acids, prescription drugs. SXR highly expressed in the liver intestine, where it regulates cytochrome P450 3A4 (CYP3A4), which turn controls steroid hormone metabolism. However, unclear whether Food Drug Administration (FDA)-approved plasticizers exert such activity. In present study, we evaluated effects of FDA-approved on SXR-mediated transcription vitro luciferase reporter,...
We have found that N-acetylneuraminic acid (NANA) consumes toxic hydrogen peroxide (H(2)O(2)) under physiological conditions. Close investigation of this finding revealed NANA was oxidized by an equimolar amount H(2)O(2) to provide its decarboxylated product, 4-(acetylamino)-2,4-dideoxy-D-glycero-D-galacto-octonic (ADOA). To date, there been little data on reaction, and significance has not discussed. Examining the detoxification in cultured cells with NANA, we were able confirm cell death...
An insoluble and assembled catalyst of palladium a non-cross-linked amphiphilic polymer were developed. In the presence 50-500 ppm mol equiv catalyst, Suzuki-Miyaura reaction proceeded efficiently under organic solvent-free conditions. The was reused 10 times without any decrease in activity recycled special treatment.[structure: see text]
A new concept for catalytic reactions in aqueous media is demonstrated by using a temperature-responsive polymer support, poly(N-alkylacrylamide), which converted into catalyst assembly with phosphotungstic acid. At high temperature, the highly active oxidation of alcohols H2O2 owing to formation emulsions, whereas product and are easily separated at low temperature (see scheme).
The atropisomeric enantiomers of 7-, 8-, and 9-membered-ring dibenzolactams were separated by using chiral HPLC, their stereochemistries clarified X-ray crystallographic analysis. atropisomers showed high stereochemical stability with the 8-membered ring being most stable. In 7- dibenzolactams, highly stereoselective C7-methylation proceeded from lower side to provide products a C7-methyl group in pseudoaxial orientation, which converted thermodynamically more stable isomers pseudoequatorial...
Latent chirality: Atropisomerism in the vaptan class of vasopressin receptor ligands with N-benzoyl benzo-fused seven-membered-ring nitrogen heterocycles was investigated by freezing axis ortho substitution. The aS/aR atropisomers caused ArN(CO) were separated to reveal that recognizes cis,aS conformation (see picture; R=CH3, X=CO, Y=H) when it binds ligand.
The various inositol polyphosphates have been found to trigger many important biological processes. Although the knowledge of this phosphoinositide signaling system has discovered in past 10 years, factors remain unclear. For reason, there is an increased demand for supplies d-myo-inositol and particularly novel analogues investigate these mechanisms more detail. Herein, we report efficient syntheses all diastereoisomers starting with 6-O-acetyl-5-enopyranosides. Conversion...
To elucidate the active conformation of indometacin that differentiates between cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), stereochemistry around N-benzoylated indole moiety was studied. Resolution stable atropisomers as representative conformations found to be possible by restricting rotation about N−C7′ and/or C7′−C1′ bond. Only aR-isomer showed specific inhibition COX-1, COX-2 not inhibited either atropisomer.
The anti and syn isomers of tolvaptan-type compounds, N-benzoyl-5-hydroxy-1-benzazepines (5a–c), were prepared in a stereocontrolled manner by biasing the conformation with methyl group at C9 C6, respectively, enantiomeric forms separated. Examination affinity human vasopressin receptors revealed that axial chirality (aS) plays more important role than central C5 receptor recognition, most preferable form was shown to be (E,aS,5S).