A5072676130- Dermatology and Skin Diseases
- Advancements in Transdermal Drug Delivery
- Contact Dermatitis and Allergies
- Skin and Cellular Biology Research
- Polysaccharides and Plant Cell Walls
- Bee Products Chemical Analysis
- Diverse Approaches in Healthcare and Education Studies
- Ion Channels and Receptors
- Healthcare and Venom Research
- Immunodeficiency and Autoimmune Disorders
- Antimicrobial Peptides and Activities
- Health and Wellbeing Research
- Pressure Ulcer Prevention and Management
- Ocular Surface and Contact Lens
- Plant Surface Properties and Treatments
- Hair Growth and Disorders
- Immune Cell Function and Interaction
- Skin Protection and Aging
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- Sarcoma Diagnosis and Treatment
- Plant Reproductive Biology
- Urticaria and Related Conditions
- Vascular Tumors and Angiosarcomas
- Nail Diseases and Treatments
RIKEN Center for Integrative Medical Sciences
2016-2024
Keio University
2015-2023
SKiN Health
2016
Abstract The stratum corneum is the outermost skin layer with a vital role in barrier function. It comprised of dead keratinocytes (corneocytes) and known to maintain its thickness by shedding cells, although, precise mechanisms that safeguard maturation homeostasis remain unclear. Previous ex vivo studies have suggested neutral-to-acidic pH gradient corneum. Here, we use intravital imaging at single-corneocyte resolution demonstrate corneocytes actually undergo differentiation develop three...
Significance In specific tissues, cell death does not represent the end of function. The uppermost stratum granulosum keratinocytes (SG1 cells) facilitates their conversion into corneum (SC) corneocytes. Such cells are removed by efferocytosis as would occur after apoptosis or necrosis; instead, nonviable bodies contribute to protective barrier function SC. present study demonstrates that SG1 is initiated via a single episode prolonged intracellular Ca 2+ elevation, followed rapid...
Abstract Drug‐induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug adverse skin eruption visceral organ involvement. The characteristic clinical features of DIHS/DRESS are reactivation human herpesviruses (HHV) the development autoimmune diseases, but their pathogenesis associations not yet understood. Here, we report 66‐year‐old man who presented fever, generalized erythema, diffuse lymphadenopathy, diarrhea after 3 weeks...
【目的】救急集中治療領域では褥瘡発生のハイリスク状態にある患者が多い。我々は看護師によるチームでの褥瘡予防対策を行ってきた。今回，患者の褥瘡発生に関わる要因を検討することで褥瘡予防対策の効果を検証した。【方法】岡山大学病院高度救命救急センターに入室した379人の患者を対象とした。看護師によるチームでの褥瘡予防対策を行った患者203人を介入群とし，それ以前の患者176人を対照群とした。介入群と対照群の褥瘡発生率を比較し，ならびにリスク要因についても検討した。【結果】褥瘡発生者数は，対照群20名（11％），介入群は9名（4％）と，褥瘡発生率は減少していた。ロジスティック解析によりアルブミン値と骨突出が褥瘡発生のリスク要因であり，看護師によるチームでの褥瘡予防対策は褥瘡発生リスクを減少させることが明らかとなった。【結論】看護師によるチームでの褥瘡予防対策は，褥瘡発生率の減少に有効である。
<title>Abstract</title> Stratum corneum (SC), the outermost skin layer comprising dead keratinocytes (corneocytes), plays a vital role in barrier function and maintains its thickness by shedding corneocytes, although mechanisms safeguarding SC homeostasis remained unclear. <italic>Ex vivo</italic> studies reported that monotonous neutral-to-acidic pH distribution exists SC; however, we present intravital SC-pH imaging at single-corneocyte resolution corneocytes undergo postmortem...